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Dr Byron Creese
Director of Research

Macfarlane, D., Dahir, I., Ali, R., Ghosalkar, N., Webb, LM., Ismail, Z., et al. (2025) 'Acceptability and feasibility of a sensor-instrumented ‘SmartSocks’ wearable prototype to detect agitation in people with dementia'. International Psychogeriatrics, 0 (in press, corrected proof). pp. 1 - 3. ISSN: 1041-6102 Open Access Link

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Choma, J., Griffiths, A., Henley, W., Mueller, C., Williams, N., Ballard, C., et al. (2025) 'Risk of stroke associated with risperidone in dementia with and without comorbid cardiovascular disease: population-based matched cohort study'. British Journal of Psychiatry, 0 (ahead of print). pp. 1 - 7. ISSN: 0007-1250 Open Access Link

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Namasivayam, AA., Fischer, CE., Abler, V., Creese, B., Gastiazoro, MP., Hermida, AP., et al. (2025) 'Recommendations for management and future investigation of psychosis in neurodegenerative disease: Findings from the International Psychogeriatric Association (IPA) working group'. International Psychogeriatrics, 0 (in press, corrected proof). pp. 1 - 9. ISSN: 1041-6102 Open Access Link

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Shwab, EK., Pathak, GA., Harvey, J., Belloy, ME., Fischer, CE., Lutz, MW., et al. (2025) 'Leveraging multiomic approaches to elucidate mechanisms of heterogeneity in Alzheimer's disease: Neuropsychiatric symptoms, co-pathologies, and sex differences'. Alzheimer's and Dementia, 21 (8). pp. 1 - 24. ISSN: 1552-5260 Open Access Link

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Malkowski, OS., Harvey, J., Townsend, NP., Kelson, MJ., Foster, CEM., Western, MJ., et al. (2025) 'Correlates and determinants of physical activity among older adults of lower versus higher socio-economic status: a systematic review and meta-analysis'. International Journal of Behavioral Nutrition and Physical Activity, 22 (1). pp. 1 - 16. ISSN: 1479-5868 Open Access Link

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Creese, B., Cummings, J., Fischer, C., Jeste, D., Ikeda, M., Mills, K., et al. (2025) 'Pre-psychosis in later life as a risk factor for progressive cognitive decline: Findings from the IPA psychosis in neurodegenerative disease working group'. International Psychogeriatrics, 0 (in press, corrected proof). pp. 1 - 4. ISSN: 1041-6102 Open Access Link

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Albertyn, CP., Guu, T-W., Chu, P., Creese, B., Young, A., Velayudhan, L., et al. (2025) 'Sativex (nabiximols) for the treatment of Agitation & Aggression in Alzheimer’s dementia in UK nursing homes: a randomised, double-blind, placebo-controlled feasibility trial'. Age and Ageing, 54 (6). pp. 1 - 10. ISSN: 0002-0729 Open Access Link

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Guan, DX., Aundhakar, A., Tomaszewski Farias, S., Ballard, C., Creese, B., Corbett, A., et al. (2025) 'Vascular risk factor associations with subjective cognitive decline and mild behavioral impairment'. Brain Communications, 7 (3). pp. 1 - 12. ISSN: 2632-1297 Open Access Link

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Mudalige, D., Guan, DX., Ballard, C., Creese, B., Corbett, A., Pickering, E., et al. (2025) 'Early life factors and dementia risk: A study of adverse childhood experiences and later-life cognition and behaviour'. Public Health, 242. pp. 172 - 178. ISSN: 0033-3506

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Kouhsar, M., Weymouth, L., Smith, AR., Imm, J., Bredemeyer, C., Wedatilake, Y., et al. (2025) 'A brain DNA co‐methylation network analysis of psychosis in Alzheimer's disease'. Alzheimer's and Dementia, 21 (2). pp. 1 - 14. ISSN: 1552-5260 Open Access Link

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Harvey, J., Smith, AR., Weymouth, LS., Smith, RG., Castanho, I., Hubbard, L., et al. (2025) 'Epigenetic insights into neuropsychiatric and cognitive symptoms in Parkinson’s disease: A DNA co-methylation network analysis'. npj Parkinson's Disease, 11 (1). pp. 1 - 10. ISSN: 2373-8057 Open Access Link

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L’Heureux, JE., Corbett, A., Ballard, C., Vauzour, D., Creese, B., Winyard, PG., et al. (2025) 'Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment and APOE4 genotype'. PNAS Nexus, 4 (1). pp. 1 - 10. ISSN: 2752-6542 Open Access Link

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Gilchrist, L., Spargo, TP., Green, RE., Coleman, JRI., Howard, DM., Thorp, JG., et al. (2025) 'Depression symptom-specific genetic associations in clinically diagnosed and proxy case Alzheimer’s disease'. Nature Mental Health, 3 (2). pp. 212 - 228.Open Access Link

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Adams, MJ., Streit, F., Meng, X., Awasthi, S., Adey, BN., Choi, KW., et al. (2025) 'Trans-ancestry genome-wide study of depression identifies 697 associations implicating cell types and pharmacotherapies'. Cell, 188 (3). pp. 640 - 652. ISSN: 0092-8674 Open Access Link

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Guan, DX., Peters, ME., Pike, GB., Ballard, C., Creese, B., Corbett, A., et al. (2024) 'Cognitive, behavioral, and functional outcomes of suspected mild traumatic brain injury in community-dwelling older persons without mild cognitive impairment or dementia'. Journal of the Academy of Consultation-Liaison Psychiatry, 66 (2). pp. 118 - 129. ISSN: 0033-3182 Open Access Link

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Ismail, Z., Guan, DX., Vellone, D., Ballard, C., Creese, B., Corbett, A., et al. (2024) 'The Canadian platform for research online to investigate health, quality of life, cognition, behaviour, function, and caregiving in aging (CAN-PROTECT): Study protocol, platform description, and preliminary analyses'. Aging and Health Research, 4 (4). pp. 1 - 9. ISSN: 2667-0321 Open Access Link

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Guan, DX., Mortby, ME., Pike, GB., Ballard, C., Creese, B., Corbett, A., et al. (2024) 'Linking cognitive and behavioral reserve: Evidence from the CAN-PROTECT study'. Alzheimer's and Dementia: Translational Research and Clinical Interventions, 10 (4). pp. 1 - 11. ISSN: 2352-8737 Open Access Link

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Warring, I., Guan, D., Ballard, C., Creese, B., Corbett, A., Pickering, E., et al. (2024) 'Mild Behavioral Impairment and Quality of Life in Community Dwelling Older Adults'. International Journal of Geriatric Psychiatry, 39 (10). pp. 1 - 12. ISSN: 0885-6230 Open Access Link

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Lennon, MJ., Rigney, G., Creese, B., Aarsland, D., Hampshire, A., Ballard, C., et al. (2024) 'Sports-related concussion not associated with long-term cognitive or behavioural deficits: the PROTECT-TBI study'. Journal of Neurology, Neurosurgery and Psychiatry, 96 (4). pp. 397 - 405. ISSN: 0022-3050 Open Access Link

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Rao, R., Velayudhan, L., Creese, B., Aarsland, D., Lewis, C., Kalafatis, C., et al. (2024) 'Daily cannabis use and cognitive impairment in community residents aged 50 and over'. Journal of Substance Use, 30 (4). pp. 561 - 567. ISSN: 1465-9891

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Mudalige, D., Guan, DX., Ballard, C., Creese, B., Corbett, A., Pickering, E., et al. (2024) 'The mind and motion: exploring the interplay between physical activity and Mild Behavioral Impairment in dementia-free older adults'. International Review of Psychiatry, 36 (3). pp. 196 - 207. ISSN: 0954-0261 Open Access Link

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Stefansson, H., Walters, GB., Sveinbjornsson, G., Tragante, V., Einarsson, G., Helgason, H., et al. (2024) 'Homozygosity for R47H in TREM2 and the Risk of Alzheimer's Disease'. New England Journal of Medicine, 390 (23). pp. 2217 - 2219. ISSN: 0028-4793

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Akhanemhe, R., Stevelink, SAM., Corbett, A., Ballard, C., Brooker, H., Creese, B., et al. (2024) 'Cardiovascular and lifestyle risk factors of mild cognitive impairment in UK veterans and non-veterans'. Occupational Medicine, 74 (4). pp. 274 - 282. ISSN: 0962-7480 Open Access Link

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Antonsdottir, IM., Creese, B., Klei, L., DeMichele-Sweet, MAA., Weamer, EA., Garcia-Gonzalez, P., et al. (2024) 'Genetic associations with psychosis and affective disturbance in Alzheimer's disease'. Alzheimer’s & Dementia: Translational Research & Clinical Interventions, 10 (2). pp. 1 - 11. ISSN: 2352-8737 Open Access Link

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Corbett, A., Williams, G., Creese, B., Hampshire, A., Palmer, A., Brooker, H. and et al. (2024) 'Impact of Short-Term Computerized Cognitive Training on Cognition in Older Adults With and Without Genetic Risk of Alzheimer's Disease: Outcomes From the START Randomized Controlled Trial'. Journal of the American Medical Directors Association, 25 (5). pp. 860 - 865. ISSN: 1525-8610 Open Access Link

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Vetere, G., Williams, G., Ballard, C., Creese, B., Hampshire, A., Palmer, A., et al. (2024) 'The relationship between playing musical instruments and cognitive trajectories: Analysis from a UK ageing cohort'. International Journal of Geriatric Psychiatry, 39 (2). pp. 1 - 9. ISSN: 0885-6230 Open Access Link

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Akhanemhe, R., Stevelink, SAM., Corbett, A., Ballard, C., Brooker, H., Creese, B., et al. (2024) 'Is lifetime traumatic brain injury a risk factor for mild cognitive impairment in veterans compared to non-veterans?'. European Journal of Psychotraumatology, 15 (1). pp. 1 - 10. ISSN: 2000-8066 Open Access Link

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Stouffer, KM., Grande, X., Duezel, E., Johansson, M., Creese, B., Witter, MP., et al. (2023) 'Amidst an amygdala renaissance in Alzheimer’s disease'. Brain, 147 (3). pp. 816 - 829. ISSN: 0006-8950 Open Access Link

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Lancaster, T., Creese, B., Escott-Price, V., Driver, I., Menzies, G., Khan, Z., et al. (2023) 'Proof-of-concept recall-by-genotype study of extremely low and high Alzheimer’s polygenic risk reveals autobiographical deficits and cingulate cortex correlates'. Alzheimer's Research and Therapy, 15 (1). pp. 1 - 10. ISSN: 1758-9193 Open Access Link

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Cousins, O., Schubert, JJ., Chandra, A., Veronese, M., Valkimadi, P., Creese, B., et al. (2023) 'Microglial activation, tau and amyloid deposition in TREM2 p.R47H carriers and mild cognitive impairment patients: a multi-modal/multi-tracer PET/MRI imaging study with influenza vaccine immune challenge'. Journal of Neuroinflammation, 20 (1). pp. 1 - 13. ISSN: 1742-2094 Open Access Link

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Aakre, JA., Schulz, J., Ballard, C., Corbett, A., Bjorvatn, B., Aarsland, D., et al. (2023) 'Self-reported sleep fragmentation and sleep duration and their association with cognitive function in PROTECT, a large digital community-based cohort of people over 50'. International Journal of Geriatric Psychiatry, 38 (11). pp. 1 - 10. ISSN: 0885-6230 Open Access Link

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Corbett, A., Williams, G., Creese, B., Hampshire, A., Hayman, V., Palmer, A., et al. (2023) 'Cognitive decline in older adults in the UK during and after the COVID-19 pandemic: a longitudinal analysis of PROTECT study data'. The Lancet Healthy Longevity, 4 (11). pp. e591 - e599. ISSN: 2666-7568 Open Access Link

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Ismail, Z., Leon, R., Creese, B., Ballard, C., Robert, P. and Smith, EE. (2023) 'Optimizing detection of Alzheimer’s disease in mild cognitive impairment: a 4-year biomarker study of mild behavioral impairment in ADNI and MEMENTO'. Molecular Neurodegeneration, 18 (1). pp. 1 - 25. ISSN: 1750-1326 Open Access Link

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Creese, B., Arathimos, R., Aarsland, D., Ballard, C., Brooker, H., Hampshire, A., et al. (2023) 'Late‐life onset psychotic symptoms and incident cognitive impairment in people without dementia: Modification by genetic risk for Alzheimer's disease'. Alzheimer's & Dementia: Translational Research & Clinical Interventions, 9 (2). pp. 1 - 12. ISSN: 2352-8737 Open Access Link

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Ghahremani, M., Smith, EE., Chen, H-Y., Creese, B., Goodarzi, Z. and Ismail, Z. (2023) 'Vitamin D supplementation and incident dementia: Effects of sex, APOE, and baseline cognitive status'. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 15 (1). pp. 1 - 11. ISSN: 2352-8729 Open Access Link

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Vasconcelos Da Silva, M., Melendez-Torres, GJ., Ismail, Z., Testad, I., Ballard, C., Creese, B. and et al. (2023) 'A data-driven examination of apathy and depressive symptoms in dementia with independent replication'. Alzheimer's and Dementia: Diagnosis, Assessment and Disease Monitoring, 15 (1). pp. 1 - 22. ISSN: 2352-8729 Open Access Link

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Lennon, MJ., Brooker, H., Creese, B., Thayanandan, T., Rigney, G., Aarsland, D., et al. (2023) 'Lifetime Traumatic Brain Injury and Cognitive Domain Deficits in Late Life: The PROTECT-TBI Cohort Study'. Journal of Neurotrauma, 40 (13-14). pp. 1423 - 1435. ISSN: 0897-7151 Open Access Link

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Rogowska, M., Thornton, M., Creese, B., Velayudhan, L., Aarsland, D., Ballard, C., et al. (2022) 'Implications of Adverse Outcomes Associated with Antipsychotics in Older Patients with Dementia: A 2011–2022 Update'. Drugs and Aging, 40 (1). pp. 21 - 32. ISSN: 1170-229X Open Access Link

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Stewart, GR., Corbett, A., Ballard, C., Creese, B., Aarsland, D., Hampshire, A., et al. (2022) 'The cognitive profile of middle-aged and older adults with high vs. low autistic traits'. Autism Research, 16 (2). pp. 429 - 440. ISSN: 1939-3792 Open Access Link

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Wang, J., Spencer, A., Hulme, C., Corbett, A., Khan, Z., Vasconcelos Da Silva, M., et al. (2022) 'Healthcare utilisation, physical activity and mental health during COVID-19 lockdown: an interrupted time-series analysis of older adults in England'. European Journal of Ageing, 19 (4). pp. 1617 - 1630. ISSN: 1613-9372 Open Access Link

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Harvey, J., Reijnders, RA., Cavill, R., Duits, A., Köhler, S., Eijssen, L., et al. (2022) 'Machine learning-based prediction of cognitive outcomes in de novo Parkinson’s disease'. npj Parkinson's Disease, 8 (1). pp. 150. ISSN: 2373-8057 Open Access Link

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Creese, B. and Lunnon, K. (2022) 'Neuropsychiatric symptoms in AD: the search for mechanisms'. Nature Reviews Neurology, 18 (11). pp. 639 - 640. ISSN: 1759-4758

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Agüera-Ortiz, L., Babulal, GM., Bruneau, M-A., Creese, B., D'Antonio, F., Fischer, CE., et al. (2022) 'Psychosis as a Treatment Target in Dementia: A Roadmap for Designing Interventions'. Journal of Alzheimer's Disease, 88 (4). pp. 1203 - 1228. ISSN: 1387-2877 Open Access Link

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Wolfova, K., Creese, B., Aarsland, D., Ismail, Z., Corbett, A., Ballard, C., et al. (2022) 'Gender/Sex Differences in the Association of Mild Behavioral Impairment with Cognitive Aging'. Journal of Alzheimer's Disease, 88 (1). pp. 345 - 355. ISSN: 1387-2877 Open Access Link

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Stewart, GR., Corbett, A., Ballard, C., Creese, B., Aarsland, D., Hampshire, A., et al. (2022) 'Self-harm and Suicidality Experiences of Middle-Age and Older Adults With vs. Without High Autistic Traits'. Journal of Autism and Developmental Disorders, 53 (8). pp. 3034 - 3046. ISSN: 0162-3257 Open Access Link

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Singham, T., Saunders, R., Brooker, H., Creese, B., Aarsland, D., Hampshire, A., et al. (2022) 'Are subtypes of affective symptoms differentially associated with change in cognition over time: A latent class analysis'. Journal of Affective Disorders, 309 (15 July 2022). pp. 437 - 445. ISSN: 0165-0327 Open Access Link

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Creese, B. and Ismail, Z. (2022) 'Mild behavioral impairment: measurement and clinical correlates of a novel marker of preclinical Alzheimer’s disease'. Alzheimer's Research and Therapy, 14 (1). pp. 1 - 5. ISSN: 1758-9193 Open Access Link

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Arathimos, R., Fabbri, C., Vassos, E., Davis, KAS., Pain, O., Gillett, A., et al. (2022) 'Latent subtypes of manic and/or irritable episode symptoms in two population-based cohorts'. British Journal of Psychiatry, 221 (6). pp. 722 - 731. ISSN: 0007-1250 Open Access Link

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Ismail, Z., Creese, B., Aarsland, D., Kales, HC., Lyketsos, CG., Sweet, RA. and et al. (2022) 'Psychosis in Alzheimer disease — mechanisms, genetics and therapeutic opportunities'. Nature Reviews Neurology, 18 (3). pp. 131 - 144. ISSN: 1759-4758 Open Access Link

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Stewart, GR., Corbett, A., Ballard, C., Creese, B., Aarsland, D., Hampshire, A., et al. (2021) 'Traumatic life experiences and post-traumatic stress symptoms in middle-aged and older adults with and without autistic traits'. International Journal of Geriatric Psychiatry, 37 (2). pp. 1 - 10. ISSN: 0885-6230 Open Access Link

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