Pazoki
raha pazok md phd fhea is a medical doctor and an epidemiologist. she studied epidemiology at the netherlands institute for health sciences (nihes) and in the university of amsterdam. she worked with various cohort and case control studies such as the arrhythmia genetics in the netherlands (agnes), the rotterdam study, the airwave health monitoring study and the uk bio bank. in 2016, she joined the department of epidemiology and bio-statistics at imperial college london as a research associate. in 2020, she started a teaching & research academic position at brunel university london. dr pazoki specializes in the field of health data research, with a primary focus on the epidemiology of cardiometabolic diseases. she holds a particular interest in exploring causal inference and precision medicine by leveraging genomics and extensive health data sets with sample sizes exceeding 500,000 individuals. her expertise spans various domains, including precision medicine, global health, interventions, and the application of artificial intelligence for predicting health outcomes. she harbors a keen interest in identification of the relationship between circulating molecules and biomarkers, nutrition, lifestyle choices, genetic factors, and their collective contribution to the modulation of health risk factors and outcomes. she was the first to identify 517 novel genetic loci associated with liver enzymes and the first to show the causal effect of liver dysfunction on cardiovascular diseases. in addition, she is the first to show the effect of the alcohol consumption wdpcp gene in lipid metabolism, and liver cirrhosis. (genetic) epidemiology of cardiovascular diseases big data genome-wide association studies genetic risk scores mendelian randomization machine learning dr paozki is a founder and director of the cardiovascular and metabolic research group hosting researchers and academics across brunel university with direct or indirect research interest involving cardiometabolic aetiology, prevention, and health. we work in various areas to identify causes of cardiometabolic diseases (environmental, lifestyle, molecular, and clinical) and provide insight into how they interplay. we use the information for better prevention of cardiometabolic diseases in the community. if you are a msc graduates (with upper second class degree or higher) in the relevant field to the above research area, please contact dr raha pazoki (raha.pazoki@brunel.ac.uk). postgraduate fees and funding | brunel university london or scholarships and bursaries | brunel university london and other funding | brunel university london
Dr Raha Pazoki
Raha Pazok MD PhD FHEA is a medical doctor and an epidemiologist. She studied Epidemiology at the Netherlands Institute for Health Sciences (NIHES) and in the University of Amsterdam. She worked with various cohort and case control studies such as the Arrhythmia Genetics in the Netherlands (AGNES), the Rotterdam Study, the Airwave Health Monitoring Study and the UK Bio bank. In 2016, she joined the Department of Epidemiology and Bio-statistics at Imperial College London as a Research Associate. In 2020, she started a Teaching & Research academic position at Brunel University London. Dr Pazoki specializes in the field of health data research, with a primary focus on the epidemiology of cardiometabolic diseases. She holds a particular interest in exploring causal inference and precision medicine by leveraging genomics and extensive health data sets with sample sizes exceeding 500,000 individuals. Her expertise spans various domains, including precision medicine, global health, interventions, and the application of artificial intelligence for predicting health outcomes. She harbors a keen interest in identification of the relationship between circulating molecules and biomarkers, nutrition, lifestyle choices, genetic factors, and their collective contribution to the modulation of health risk factors and outcomes. She was the first to identify 517 novel genetic loci associated with liver enzymes and the first to show the causal effect of liver dysfunction on cardiovascular diseases. In addition, she is the first to show the effect of the alcohol consumption WDPCP gene in lipid metabolism, and liver cirrhosis. (Genetic) Epidemiology of Cardiovascular Diseases Big Data Genome-wide Association Studies Genetic risk scores Mendelian Randomization Machine Learning Dr Paozki is a founder and director of the Cardiovascular and Metabolic Research Group hosting researchers and academics across Brunel university with direct or indirect research interest involving cardiometabolic aetiology, prevention, and health. We work in various areas to identify causes of cardiometabolic diseases (environmental, lifestyle, molecular, and clinical) and provide insight into how they interplay. We use the information for better prevention of cardiometabolic diseases in the community. If you are a MSc graduates (with upper second class degree or higher) in the relevant field to the above research area, please contact Dr Raha Pazoki (raha.pazoki@brunel.ac.uk). Postgraduate fees and funding | Brunel University London or Scholarships and Bursaries | Brunel University London and Other funding | Brunel University London
Victor
christina joined brunel in october 2009. she is professor of gerontology and public health in the college of health, medicine and life sciences and associate pvc-research culture and governance. she is also director of the institute of health, medicine and environments. christina started her academic career as a geographer with a particular interest in the spatial distribution of health and illness and access to, and provision of, health and social care. she has a ba in geography from swansea university and an m phil in medical geography from nottingham. it was whilst working at the medical school in cardiff that she developed her interests in gerontology and her phd investigated outcome after discharge for older people in wales and she now focuses her interests in public health/population medicine on to the experiences of old age and later life. she has a special interest in researching loneliness and isolation. christina’s initial research interests were focussed upon health and health inequalities and the evaluation of services for older people. more recently she developed a keen interest in loneliness and isolation; the benefits of exercise and activity in later life and the experiences of old age and later life amongst minority communities and the experience of ageing for people with intellectual disabilities. she has received funding for her research from a range of funders including esrc, nihr, dunhill medical trust, leverhulme and the british academy. christina has written over 400 peer reviewed articles and published 8 books in the field of gerontology. she is a fellow of the faculty of public health and an academician of the academy of social sciences. in 2017 christina was awarded the lifetime achievement award of the british society of gerontology and awarded fellowship of the gerontological society of america. her work has been cited 23,000 times and her h idex is 78. she has 3 articles in the list of the 100 most cited articles in the field of loneliness and is ranked as one of the top 100 social science and humanities researchers in the uk. qualifications: phd, m phil, ba ageing and later life wellbeing across the lifecourse loneliness and isolation my principal research interests are focussed around understanding the social context of ageing and later life. more specifically i have specialist interests around loneliness and social isolation in later life; care and caring; growing old amongst minority communities; physical activity, exercise and later life and the use of secondary data analysis in gerontological research. i also am active in the broad areas of service evaluation, health inequalities and public health aspects of old age and population ageing, especially in the developing world. teaching responsibilities: contributor to research methods and evidence based public health modules contyrubute to modules focusing upon older people msc dissertation supervisor
Professor Christina Victor
Christina joined Brunel in October 2009. She is Professor of Gerontology and Public Health in the College of Health, Medicine and Life Sciences and Associate PVC-Research Culture and Governance. She is also Director of the Institute of Health, Medicine and Environments. Christina started her academic career as a geographer with a particular interest in the spatial distribution of health and illness and access to, and provision of, health and social care. She has a BA in Geography from Swansea University and an M Phil in medical geography from Nottingham. It was whilst working at the Medical School in Cardiff that she developed her interests in gerontology and her PhD investigated outcome after discharge for older people in Wales and she now focuses her interests in public health/population medicine on to the experiences of old age and later life. She has a special interest in researching loneliness and isolation. Christina’s initial research interests were focussed upon health and health inequalities and the evaluation of services for older people. More recently she developed a keen interest in loneliness and isolation; the benefits of exercise and activity in later life and the experiences of old age and later life amongst minority communities and the experience of ageing for people with intellectual disabilities. She has received funding for her research from a range of funders including ESRC, NIHR, Dunhill Medical Trust, Leverhulme and the British Academy. Christina has written over 400 peer reviewed articles and published 8 books in the field of gerontology. She is a Fellow of the Faculty of Public Health and an Academician of the Academy of Social Sciences. In 2017 Christina was awarded the Lifetime Achievement award of the British Society of Gerontology and awarded Fellowship of the Gerontological Society of America. Her work has been cited 23,000 times and her H idex is 78. She has 3 articles in the list of the 100 most cited articles in the field of loneliness and is ranked as one of the top 100 social science and humanities researchers in the UK. Qualifications: PhD, M Phil, BA Ageing and later life Wellbeing across the lifecourse Loneliness and isolation My principal research interests are focussed around understanding the social context of ageing and later life. More specifically I have specialist interests around loneliness and social isolation in later life; care and caring; growing old amongst minority communities; physical activity, exercise and later life and the use of secondary data analysis in gerontological research. I also am active in the broad areas of service evaluation, health inequalities and public health aspects of old age and population ageing, especially in the developing world. Teaching Responsibilities: Contributor to research methods and evidence based public health modules Contyrubute to modules focusing upon older people MSc Dissertation supervisor
Mansfield
career history louise mansfield is professor of sport, health and social sciences and research lead for welfare, health and wellbeing in the institute of environment, health and societies. her research focuses on the relationship between sport, physical activity and public health and wellbeing. she is interested in partnership and community approaches in sport and physical activity and issues of health, wellbeing, inequality and diversity. she has led research projects for the department of health, youth sport trust, sportscotland, economic and social research council, medical research council, macmillan cancer support, public health england and sport england. she sits on the editorial boards for leisure studies, qualitative research in sport, exercise and health and the international review for the sociology of sport and is managing editor of annals of leisure research. louise is known for is known for developing evidence to inform policy and practice. community approaches to sport, public health and wellbeing sociology of sport; gender and feminist theories, social inequalities, public health and wellbeing, coproduction and partnership qualitative research methods and process evaluations intervention and evaluation strategies in community sport research evidence reviews for research, policy and practice including focus on qualitative synthesis translation, dissemination and mobilisation of evidence strategies and practices for uk and international sport and culture sector audiences in policy and practice and both academic and non-academic organisations. community sport, physical activity and public health and wellbeing. sociology of sport and social inequalities. participatory and coproduction strategies and methods in developing evidence to inform policy and practice in the culture and sports sectors. i am a fellow of the he academy. i embrace a research led teaching approach. my teaching skills have been established in both further and higher education and i hold postgraduate teaching qualifications. i advocate a teaching philosophy that embraces a mix of styles from the traditional large lecture to more interactive student-led approaches using new technology. i have designed and delivered a range of modules at undergraduate and postgraduate level that draw from across theoretical and methodological perspectives in the social sciences to understand sport, physical activity, health and well-being and i continue to engage in on-going curriculum developments in those fields.
Professor Louise Mansfield
Career History Louise Mansfield is Professor of Sport, Health and Social Sciences and Research Lead for Welfare, Health and Wellbeing in the Institute of Environment, Health and Societies. Her research focuses on the relationship between sport, physical activity and public health and wellbeing. She is interested in partnership and community approaches in sport and physical activity and issues of health, wellbeing, inequality and diversity. She has led research projects for the Department of Health, Youth Sport Trust, sportscotland, Economic and Social Research Council, Medical Research Council, Macmillan Cancer Support, Public Health England and Sport England. She sits on the editorial boards for Leisure Studies, Qualitative Research in Sport, Exercise and Health and the International Review for the Sociology of Sport and is Managing Editor of Annals of Leisure Research. Louise is known for is known for developing evidence to inform policy and practice. Community approaches to sport, public health and wellbeing Sociology of sport; gender and feminist theories, social inequalities, public health and wellbeing, coproduction and partnership Qualitative research methods and process evaluations Intervention and evaluation strategies in community sport research Evidence reviews for research, policy and practice including focus on qualitative synthesis Translation, dissemination and mobilisation of evidence strategies and practices for UK and international sport and culture sector audiences in policy and practice and both academic and non-academic organisations. Community sport, physical activity and public health and wellbeing. Sociology of sport and social inequalities. Participatory and coproduction strategies and methods in developing evidence to inform policy and practice in the culture and sports sectors. I am a Fellow of the HE Academy. I embrace a research led teaching approach. My teaching skills have been established in both further and higher education and I hold postgraduate teaching qualifications. I advocate a teaching philosophy that embraces a mix of styles from the traditional large lecture to more interactive student-led approaches using new technology. I have designed and delivered a range of modules at undergraduate and postgraduate level that draw from across theoretical and methodological perspectives in the social sciences to understand sport, physical activity, health and well-being and I continue to engage in on-going curriculum developments in those fields.
Bailey
dr daniel bailey is a senior lecturer in sport, health and exercise sciences in the division of sport, health and exercise sciences, department of life sciences. he is co-director of the centre for physical activity in health and disease after previously establishing and leading the sedentary behaviour, health and disease research group. dr bailey's research investigates the relationship between sedentary behaviour and chronic health conditions, with a particular focus on non-communicable disease. this research includes the epidemiology of sedentary behaviour and associations with non-communicable disease risks, controlled laboratory studies examining the acute effects of breaking up prolonged sitting on cardiometabolic biomarkers, and the development and evaluation of interventions to reduce sedentary behaviour and increase physical activity in a range of population groups at risk of adverse health such as people with type 2 diabetes, office workers, individuals with a spinal cord injury, and older adults with frailty. dr bailey has been awarded multiple research grants from funding bodies and industry partners to support his research and has published a large number of research articles in his field of research. he has delivered multiple conference presentations and invited talks across the uk and europe and was technical advisor for the qatar national physical activity guidelines 2nd edition, 2021. dr bailey is deputy chair of the british association of sport and exercise sciences (bases) physical activity for health division and is a member of the bases conference planning group. dr bailey was also a member of the scientific global leadershop committee for the 8th international society for physical activity and health (ispah) congress. dr bailey has a wealth of experience teaching physical activity, sedentary behaviour and health topics at undergraduate and postgraduate level and uses innovative teaching approaches in his practice including research-informed teaching, bleneded and authentic learning, and flipped classrooms. dr bailey's research investigates the relationship between sedentary behaviour and chronic health conditions with examples being cardiovascular disease, type 2 diabetes, sarcopenia and mental ill-health. his research has spanned from the epidemiological analyses of sedentary behaviour and chronic disease risk, laboratory-based studies examining the benefits of breaking up prolonged sitting time on markers of health to provide proof-of-concept, leading to the development and evaluation of interventions to reduce sedentary behaviour. dr bailey has established an interdisciplinary and multi-institutional network of collaborators to deliver this programme of research. his research has been conducted in a range of population groups and settings, including young people, workplaces, people with type 2 diabetes, spinal cord injury, older adults with frailty and sarcopenia, cardiac rehabilitation patients and police officers. this has been facilitated with his external partners such as local councils, the nhs, police forces, health charities and community organisations. dr bailey’s research has shown that high amounts of daily sitting time are associated with an increased risk of cardiovascular disease and diabetes, regardless of how much physical activity people engage in. he has also published a large number of studies showing that regularly breaking up sitting time with short, frequent bouts of light, moderate or high-intensity physical activity leads to improvements in a range of metabolic biomarkers including blood glucose, lipid levels and blood pressure. his first laboratory based study published in 2014 was the first to show postprandial glucose attenuation in response to breaking up sitting time with light-intensity walking in young healthy adults. this paper has received over 340 citations on google scholar as of february 2022. dr bailey has led successful research grant applications to various funding bodies to support his research, such as: mps society, physical activity and sedentary behaviour in the enhancement of mental health and quality of life in fabry disease, £84,007. diabetes uk, a tailored intervention to reduce sitting behaviour in people with type 2 diabetes: a randomised-controlled feasibility study, £137,510. abbeyfield research foundation, reducing sarcopenia and maintaining independent living in frail older adults via reductions in sitting time: the frail-less (less sitting and sarcopenia in frail older adults) intervention, £73,247. heart research uk, the benefits of breaking up prolonged sedentary time on cardiovascular disease risk markers in people with spinal cord injury, £86,434. he has also supervised a number of phd students to completion in addition to supervising current phd students studying in fields related to physical activity, sedentary behaviour and long-term health conditions.
Dr Daniel Bailey
Dr Daniel Bailey is a Senior Lecturer in Sport, Health and Exercise Sciences in the Division of Sport, Health and Exercise Sciences, Department of Life Sciences. He is Co-Director of the Centre for Physical Activity in Health and Disease after previously establishing and leading the Sedentary Behaviour, Health and Disease Research Group. Dr Bailey's research investigates the relationship between sedentary behaviour and chronic health conditions, with a particular focus on non-communicable disease. This research includes the epidemiology of sedentary behaviour and associations with non-communicable disease risks, controlled laboratory studies examining the acute effects of breaking up prolonged sitting on cardiometabolic biomarkers, and the development and evaluation of interventions to reduce sedentary behaviour and increase physical activity in a range of population groups at risk of adverse health such as people with Type 2 diabetes, office workers, individuals with a spinal cord injury, and older adults with frailty. Dr Bailey has been awarded multiple research grants from funding bodies and industry partners to support his research and has published a large number of research articles in his field of research. He has delivered multiple conference presentations and invited talks across the UK and Europe and was Technical Advisor for the Qatar National Physical Activity Guidelines 2nd edition, 2021. Dr Bailey is Deputy Chair of the British Association of Sport and Exercise Sciences (BASES) Physical Activity for Health Division and is a member of the BASES conference planning group. Dr Bailey was also a member of the scientific global leadershop committee for the 8th International Society for Physical Activity and Health (ISPAH) Congress. Dr Bailey has a wealth of experience teaching physical activity, sedentary behaviour and health topics at undergraduate and postgraduate level and uses innovative teaching approaches in his practice including research-informed teaching, bleneded and authentic learning, and flipped classrooms. Dr Bailey's research investigates the relationship between sedentary behaviour and chronic health conditions with examples being cardiovascular disease, Type 2 diabetes, sarcopenia and mental ill-health. His research has spanned from the epidemiological analyses of sedentary behaviour and chronic disease risk, laboratory-based studies examining the benefits of breaking up prolonged sitting time on markers of health to provide proof-of-concept, leading to the development and evaluation of interventions to reduce sedentary behaviour. Dr Bailey has established an interdisciplinary and multi-institutional network of collaborators to deliver this programme of research. His research has been conducted in a range of population groups and settings, including young people, workplaces, people with Type 2 diabetes, spinal cord injury, older adults with frailty and sarcopenia, cardiac rehabilitation patients and police officers. This has been facilitated with his external partners such as local councils, the NHS, police forces, health charities and community organisations. Dr Bailey’s research has shown that high amounts of daily sitting time are associated with an increased risk of cardiovascular disease and diabetes, regardless of how much physical activity people engage in. He has also published a large number of studies showing that regularly breaking up sitting time with short, frequent bouts of light, moderate or high-intensity physical activity leads to improvements in a range of metabolic biomarkers including blood glucose, lipid levels and blood pressure. His first laboratory based study published in 2014 was the first to show postprandial glucose attenuation in response to breaking up sitting time with light-intensity walking in young healthy adults. This paper has received over 340 citations on google scholar as of February 2022. Dr Bailey has led successful research grant applications to various funding bodies to support his research, such as: MPS Society, Physical activity and sedentary behaviour in the enhancement of mental health and quality of life in Fabry disease, £84,007. Diabetes UK, A tailored intervention to reduce sitting behaviour in people with Type 2 Diabetes: A randomised-controlled feasibility study, £137,510. Abbeyfield Research Foundation, Reducing sarcopenia and maintaining independent living in frail older adults via reductions in sitting time: The Frail-LESS (LEss Sitting and Sarcopenia in Frail older adults) intervention, £73,247. Heart Research UK, The benefits of breaking up prolonged sedentary time on cardiovascular disease risk markers in people with spinal cord injury, £86,434. He has also supervised a number of PhD students to completion in addition to supervising current PhD students studying in fields related to physical activity, sedentary behaviour and long-term health conditions.
Gavins
felicity read pharmacology at the university of sunderland, where she also embarked on an industrial placement year at bayer pharmaceuticals in slough. after completing her bsc (hons), she moved to london to study for a ph.d. in pharmacology at queen mary university london, supported by the british heart foundation (bhf). felicity was then awarded a bhf junior research fellowship to undertake further research both in the uk and the usa. in 2007 felicity joined imperial college london to take up a lectureship position in the centre for integrative mammalian physiology and pharmacology (cimpp). this was shortly followed by a senior lectureship and the appointment to deputy head of the centre of neurodegeneration & neuroinflammation. in 2013 she accepted an academic position in the usa at louisiana state university health sciences center-shreveport (lsuhsc-s) and was appointed director of the small animal imaging facility. felicity is a fellow of the british pharmacological society and of the royal society of biology. she joined brunel university london in august 2019 as professor of pharmacology and royal society wolfson fellow, and is the director of the centre for inflammation research and translational medicine (cirtm). throughout her academic career, felicity has worked with and served on numerous national and international research councils, medical charities and learned societies. she has published widely in her field and received a number of awards and honours for her work. she has received funding for her research from a range of funders including: the royal society and the wolfson foundation (rswf), the british heart foundation (bhf), the medical research council (mrc), the biotechnology and biological sciences research council (bbsrc), the american heart association (aha), and the national institutes of health/national heart, lung, and blood institute (nih/nhlbi). felicity continues to be actively involved in public and patient organizations which has been immensely instructive for her research. she is also dedicated to promoting mentoring and collaborative research, along with facilitating mentoring of post-doctoral fellows/early-career investigators. inflammation thrombosis (arterial and venous) resolution of inflammation immune mediated responses in normal and pathological conditions neutrophil-platelet interactions ischaemia reperfusion injury (i/ri) healthy ageing formyl peptide receptors (fprs) annexin a1 biology sickle cell disease inflammation in cancer pre-clinical imaging drug discovery and resolution biologics novel drug delivery systems e.g nanocarriers the principle focus of my research is elucidate and understand the complex roles played by immune cells in vascular inflammation and thrombosis. the aim of my research it to design tailored next generation therapeutics for inflammatory pathologies that temper inflammation and enhance resolution. within the continuum of an inflammatory response, the objective of my research is to study the role of the microvasculature as a dynamic-interface between circulating blood cells and immune cells (such as neutrophils and platelets) and tissue. my lab focuses on how circulating cells communicate, adhere and migrate across the endothelium and the pathways by which these circulating and resident cells can render systemic inflammatory responses and alter local inflammatory and thrombotic states. by targeting the pathophysiology of endogenous pro-resolving pathways such as the annexin a1-formyl peptide receptor (anxa1-fpr) pathway, we hope to identify novel and innovative anti-inflammatory therapeutics for the treatment of cardiovascular and cerbrovascular diseas the research in my laboratory crosses the boundaries between integrative physiology and pharmacology and uses multidisciplinary approaches to advance understanding of the vascular physiology and pathophysiology of inflammatory and related disorders, at the molecular, cellular, tissue and whole organism levels. to achieve this goal, we use a technological toolbox compromising of various experimental in-silico, in-vitro and in-vivo systems and advanced imaging modalities (including confocal intravital microscopy, magnetic resonance imaging [mri]; positron emission tomography [pet], and in-vivo imaging systems [ivis]), coupled with multi-omics approaches to dissect the contribution of neutrophils and platelets in inflammation, thrombosis and vascular dysfunction. development of research students and post-doctoral fellows/early career researchers. dedicated to promoting mentoring and ensuring equality and diversity. teaching responsibilities: bb3091 final year project (block lead) bb5604 msc dissertation research project bb3802 problem solving and data analysis bb3801 scientific communication bb2802 primary literature interrogation & synthesis bb2803 data evaluation and reporting bb2555 work placement bb1700 tutoring bb2700 tutoring bb3700 tutoring
Professor Felicity Gavins
Felicity read Pharmacology at the University of Sunderland, where she also embarked on an industrial placement year at Bayer Pharmaceuticals in Slough. After completing her BSc (Hons), she moved to London to study for a Ph.D. in Pharmacology at Queen Mary University London, supported by the British Heart Foundation (BHF). Felicity was then awarded a BHF Junior Research Fellowship to undertake further research both in the UK and the USA. In 2007 Felicity joined Imperial College London to take up a Lectureship position in the Centre for Integrative Mammalian Physiology and Pharmacology (CIMPP). This was shortly followed by a senior lectureship and the appointment to Deputy Head of The Centre of Neurodegeneration & Neuroinflammation. In 2013 she accepted an academic position in the USA at Louisiana State University Health Sciences Center-Shreveport (LSUHSC-S) and was appointed Director of The Small Animal Imaging Facility. Felicity is a Fellow of the British Pharmacological Society and of the Royal Society of Biology. She joined Brunel University London in August 2019 as Professor of Pharmacology and Royal Society Wolfson Fellow, and is the Director of The Centre for Inflammation Research and Translational Medicine (CIRTM). Throughout her academic career, Felicity has worked with and served on numerous national and international research councils, medical charities and learned societies. She has published widely in her field and received a number of awards and honours for her work. She has received funding for her research from a range of funders including: the Royal Society and the Wolfson Foundation (RSWF), the British Heart Foundation (BHF), the Medical Research Council (MRC), the Biotechnology and Biological Sciences Research Council (BBSRC), the American Heart Association (AHA), and the National Institutes of Health/National Heart, Lung, and Blood Institute (NIH/NHLBI). Felicity continues to be actively involved in public and patient organizations which has been immensely instructive for her research. She is also dedicated to promoting mentoring and collaborative research, along with facilitating mentoring of post-doctoral fellows/early-career investigators. Inflammation Thrombosis (arterial and venous) Resolution of inflammation Immune mediated responses in normal and pathological conditions Neutrophil-Platelet interactions Ischaemia reperfusion injury (I/RI) Healthy ageing Formyl Peptide Receptors (FPRs) Annexin A1 Biology Sickle Cell Disease Inflammation in Cancer Pre-clinical imaging Drug discovery and resolution biologics Novel drug delivery systems e.g Nanocarriers The principle focus of my research is elucidate and understand the complex roles played by immune cells in vascular inflammation and thrombosis. The aim of my research it to design tailored next generation therapeutics for inflammatory pathologies that temper inflammation and enhance resolution. Within the continuum of an inflammatory response, the objective of my research is to study the role of the microvasculature as a dynamic-interface between circulating blood cells and immune cells (such as neutrophils and platelets) and tissue. My lab focuses on how circulating cells communicate, adhere and migrate across the endothelium and the pathways by which these circulating and resident cells can render systemic inflammatory responses and alter local inflammatory and thrombotic states. By targeting the pathophysiology of endogenous pro-resolving pathways such as the Annexin A1-Formyl Peptide Receptor (AnxA1-FPR) pathway, we hope to identify novel and innovative anti-inflammatory therapeutics for the treatment of cardiovascular and cerbrovascular diseas The research in my laboratory crosses the boundaries between Integrative physiology and pharmacology and uses multidisciplinary approaches to advance understanding of the vascular physiology and pathophysiology of inflammatory and related disorders, at the molecular, cellular, tissue and whole organism levels. To achieve this goal, we use a technological toolbox compromising of various experimental in-silico, in-vitro and in-vivo systems and advanced imaging modalities (including confocal intravital microscopy, magnetic resonance imaging [MRI]; positron emission tomography [PET], and in-vivo imaging systems [IVIS]), coupled with multi-omics approaches to dissect the contribution of neutrophils and platelets in inflammation, thrombosis and vascular dysfunction. Development of research students and post-doctoral fellows/early career researchers. Dedicated to promoting mentoring and ensuring equality and diversity. Teaching Responsibilities: BB3091 Final Year Project (Block lead) BB5604 MSc Dissertation Research Project BB3802 Problem Solving and Data Analysis BB3801 Scientific Communication BB2802 Primary literature interrogation & synthesis BB2803 Data Evaluation and Reporting BB2555 Work Placement BB1700 Tutoring BB2700 Tutoring BB3700 Tutoring