SummaryTraditional chemicals risk assessment has a quite artificial orientation: It treats chemicals as if they act in isolation, when in reality there is exposure to multiple substances. For more than 15 years, our team have been engaged in efforts to find ways of improving risk assessment by taking “cocktail effects” into account. This work has proceeded in stages: Firstly, when we have information about the toxicity of individual mixture components, is it possible to predict the effects of the combination? Working with mixtures of endocrine disrupting chemicals we have shown that this is achievable. Secondly, what is the composition of mixtures of environmental relevance, and what effects do they produce? Work on this aspect of the mixtures issue is currently proceeding in our group. We are also interested in making an impact on chemical regulation by addressing the questions: Which chemicals should be grouped together for mixtures risk assessment? What are scientifically sound grouping criteria?
We have prepared scientific reports for the European Commission, including the State of the Art Report on Mixture Toxicology. Currently we are writing a State of the Art Assessment for Endocrine Disrupters, a project also commissioned by the European Commission.
Another research interest is in unravelling the details of estrogen signalling and estrogen-mediated effects with a view to understanding hormonal cancers, especially breast cancer. Here, I closely collaborate with Dr Elisabete Silva.
Qualifications1983: Degree in Chemistry, Philosophy and Educational Sciences from University of Muenster, Germany 1989: PhD (with distinction) from Bremen University, Bremen, Germany
- 1990-1991: Post-doctoral Fellow at Queen Mary London, University of London.
- 1991-2000: Lecturer in Environmental Toxicology, School of Pharmacy, University of London, London.
- 2000-2005: Senior Lecturer, School of Pharmacy, University of London, London.
- 2005-2007: Reader and Head of Centre for Toxicology, School of Pharmacy, University of London, London.
- 2007-2011: Professor for Molecular Toxicology, Head of Centre for Toxicology, School of Pharmacy, University of London, London.
- 2011-present: Professor in the Institute for the Environment, Brunel University.
Newest selected publications
Axelstad, M., Hass, U., Scholze, M., Christiansen, S., Kortenkamp, A. and Boberg, J. (2018) 'EDC IMPACT: Reduced sperm counts in rats exposed to human relevant mixtures of endocrine disrupters'. Endocrine Connections, 7 (1). pp. 139 - 148.
Thrupp, TJ., Runnalls, TJ., Scholze, M., Kugathas, S., Kortenkamp, A. and Sumpter, JP. (2017) 'The consequences of exposure to mixtures of chemicals: Something from ‘nothing’ and ‘a lot from a little’ when fish are exposed to steroid hormones'. Science of the Total Environment, 619-620. pp. 1482 - 1492. ISSN: 0048-9697 Open Access Link
Martin, OV., Evans, RM., Faust, M. and Kortenkamp, A. (2017) 'A Human Mixture Risk Assessment for Neurodevelopmental Toxicity Associated with Polybrominated Diphenyl Ethers Used as Flame Retardants.'. Environmental Health Perspectives, 125 (8). pp. 087016 - 087016. ISSN: 0091-6765 Open Access Link
Bornman, MS., Aneck-Hahn, NH., de Jager, C., Wagenaar, GM., Bouwman, H., Barnhoorn, IEJ., (2017) 'Endocrine Disruptors and Health Effects in Africa: A Call for Action'. Environmental Health Perspectives, 125 (8). ISSN: 0091-6765 Open Access Linket al.
Gaudriault, P., Mazaud-Guittot, S., Lavoué, V., Coiffec, I., Lesné, L., Dejucq-Rainsford, N., (2017) 'Endocrine Disruption in Human Fetal Testis Explants by Individual and Combined Exposures to Selected Pharmaceuticals, Pesticides, and Environmental Pollutants'. Environmental Health Perspectives, 125 (8). ISSN: 0091-6765 Open Access Linket al.