Skip to Content
Exit Menu
Dr Michael Themis

Dr Michael Themis
Reader - Health and Safety

Filter

Themis, M. (2018) 'Three-dimensional cell culture: From evolution to revolution'. Philos Trans R Soc Lond B Biol Sci, 373 (1750). pp. 1750 - 1750. ISSN: 0962-8436 Open Access Link

Journal article

Khonsari, H., Schneider, M., Al-Mahdawi, S., Chianea, YG., Themis, M., Parris, C., et al. (2016) 'Lentivirus-meditated frataxin gene delivery reverses genome instability in Friedreich ataxia patient and mouse model fibroblasts'. Nature Gene Therapy, 23 (12). pp. 846 - 856. ISSN: 0969-7128 Open Access Link

Journal article

Ghorbani, M., Themis, M. and Payne, AM. (2016) 'Genome wide classification and characterisation of CpG sites in cancer and normal cells'. Computers in Biology and Medicine, 68. pp. 57 - 66. ISSN: 0010-4825 Open Access Link

Journal article

Condiotti, R., Goldenberg, D., Giladi, H., Schnitzer-Perlman, T., Simerzin, A., Galun, E., et al. (2014) 'Transduction of fetal mice with a feline lentiviral vector induces liver tumors which exhibit an E2F activation signature'. Molecular Therapy, 22 (1). pp. 59 - 68. ISSN: 1525-0016 Open Access Link

Journal article

Nowrouzi, A., Arens, A., Paruzynski, A., Schmidt, M., Cheung, WT., Al-Allaf, F., et al. (2013) 'The fetal mouse is a sensitive genotoxicity model that exposes lentiviral-associated mutagenesis resulting in liver oncogenesis'. Molecular Therapy, 21 (2). pp. 324 - 337. ISSN: 1525-0016 Open Access Link

Journal article

Themis, M. (2012) 'Monitoring for potential adverse effects of prenatal gene therapy: Genotoxicity analysis in vitro and on small animal models ex vivo and in vivo'. Methods in Molecular Biology, 891. pp. 341 - 370. ISSN: 1064-3745

Journal article

Coutelle, C., Waddington, SN. and Themis, M. (2012) 'Monitoring for potential adverse effects of prenatal gene therapy: Mouse models for developmental aberrations and inadvertent germ line transmission'. Methods in Molecular Biology, 891. pp. 329 - 340. ISSN: 1064-3745

Journal article

David, AL., Abi-Nader, KN., Weisz, B., Shaw, SWS., Themis, M., Cook, T., et al. (2010) 'ULTRASONOGRAPHIC DEVELOPMENT OF THE FETAL SHEEP STOMACH AND EVALUATION OF EARLY GESTATION ULTRASOUND-GUIDED IN UTERO I NTRAGASTRIC INJECTION'. TAIWANESE JOURNAL OF OBSTETRICS & GYNECOLOGY, 49 (1). pp. 23 - 29. ISSN: 1028-4559

Journal article

Kennea, NL., Waddington, SN., Chan, J., O'Donoghue, K., Yeung, D., Taylor, DL., et al. (2009) 'Differentiation of human fetal mesenchymal stem cells into cells with an oligodendrocyte phenotype'. Cell Cycle, 8 (7). pp. 1069 - 1079. ISSN: 1538-4101 Open Access Link

Journal article

Buckley, SMK., Waddington, SN., Jezzard, S., Bergau, A., Themis, M., MacVinish, LJ., et al. (2008) 'Intra-amniotic delivery of CFTR-expressing adenovirus does not reverse cystic fibrosis phenotype in inbred CFTR-knockout mice'. Molecular Therapy, 16 (5). pp. 819 - 824. ISSN: 1525-0016 Open Access Link

Journal article

David, AL., Weisz, B., Gregory, L., Themis, M., Cook, T., Roubliova, X., et al. (2006) 'Ultrasound-guided injection and occlusion of the trachea in fetal sheep'. Ultrasound in Obstetrics and Gynecology, 28 (1). pp. 82 - 88. ISSN: 0960-7692

Journal article

David, AL., Peebles, DM., Gregory, L., Waddington, SN., Themis, M., Weisz, B., et al. (2006) 'Clinically applicable procedure for gene delivery to fetal gut by ultrasound-guided gastric injection: Toward prenatal prevention of early-onset intestinal diseases'. Human Gene Therapy, 17 (7). pp. 767 - 779. ISSN: 1043-0342

Journal article

David, A., Weisz, B., Ruthe, A., Peebles, DM., Coutelle, C., Rodeck, CH. and et al. (2006) 'Gene transfer to human fetal tissues in vitro'. BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY, 113 (7). pp. 863 - 863. ISSN: 1470-0328

Journal article

Themis, M., Waddington, SN., Schmidt, M., von Kalle, C., Wang, Y., Al-Allaf, F., et al. (2006) 'Erratum: "Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice" (Molecular Therapy (2005) vol. 12 (763-771) 10.1016/j.ymthe.2005.07.358)'. Molecular Therapy, 13 (4). pp. 830. ISSN: 1525-0016

Journal article

Themis, M., Waddington, SN., Schmidt, M., von Kalle, C., Wang, Y., Al-Allaf, F., et al. (2006) 'Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice (vol 12, pg 763, 2005)'. Molecular Therapy, 13 (4). pp. 830 - 830. ISSN: 1525-0024

Journal article

Tolmachov, O., Ma, YL., Themis, M., Patel, P., Spohr, H., Macleod, KT., et al. (2006) 'Overexpression of connexin 43 using a retroviral vector improves electrical coupling of skeletal myoblasts with cardiac myocytes in vitro'. BMC Cardiovascular Disorders, 6 (1). pp. 25 - 25. ISSN: 1471-2261 Open Access Link

Journal article

Bigger, BW., Siapati, EK., Mistry, A., Waddington, SN., Nivsarkar, MS., Jacobs, L., et al. (2006) 'Permanent partial phenotypic correction and tolerance in a mouse model of hemophilia B by stem cell gene delivery of human factor IX.'. Gene Therapy, 13 (2). pp. 117 - 126. ISSN: 0969-7128

Journal article

Coutelle, C., Themis, M., Waddington, SN., Buckley, SMK., Gregory, LG., Nivsarkar, MS., et al. (2005) 'Gene therapy progress and prospects: Fetal gene therapy - First proofs of concept - Some adverse effects'. Gene Therapy, 12 (22). pp. 1601 - 1607. ISSN: 0969-7128

Journal article

Themis, M., Waddington, SN., Schmidt, M., von Kalle, C., Wang, YH., Al-Allaf, F., et al. (2005) 'Oncogenesis following delivery of a non-primate lentiviral gene therapy vector to fetal mice'.Autumn Meeting of the British-Toxicology-Society. Univ Bath, Bath, ENGLAND. 19 - 20 September. ELSEVIER IRELAND LTD. pp. 233 - 233. ISSN: 0300-483X

Conference paper

Siapati, EK., Bigger, BW., Miskin, J., Chipchase, D., Parsley, KL., Mitrophanous, K., et al. (2005) 'Comparison of HIV- and EIAV-based vectors on their efficiency in transducing murine and human hematopoietic repopulating cells'. Molecular Therapy, 12 (3). pp. 537 - 546. ISSN: 1525-0016

Journal article

Weisz, B., David, AL., Gregory, LG., Perocheau, D., Ruthe, A., Waddington, SN., et al. (2005) 'Targeting the respiratory muscles of fetal sheep for prenatal gene therapy for Duchenne muscular dystrophy'. American Journal of Obstetrics and Gynecology, 193 (3). pp. 1105 - 1109. ISSN: 1097-6868

Journal article

Weisz, B., David, AL., Gregory, LG., Perocheau, D., Ruthe, A., Waddington, SN., et al. (2005) 'Targeting the respiratory muscles of fetal sheep for prenatal gene therapy for Duchenne muscular dystrophy'. American Journal of Obstetrics and Gynecology, 193 (3 SUPPL.). pp. 1105 - 1109. ISSN: 0002-9378

Journal article

Buckley, SM., Waddington, SN., Jezzard, S., Lawrence, L., Schneider, H., Holder, MV., et al. (2005) 'Factors influencing adenovirus-mediated airway transduction in fetal mice'. Molecular Therapy, 12 (3). pp. 484 - 492. ISSN: 1525-0016

Journal article

Al-Allaf, FA., Tolmachov, O., Themis, M. and Coutelle, C. (2005) 'Coupled analysis of bacterial transformants and ligation mixture by duplex PCR enables detection of fatal instability of a nascent recombinant plasmid'. Journal of Biochemical and Biophysical Methods, 64 (2). pp. 142 - 146. ISSN: 0165-022X

Journal article

Bigger, BW., Waddington, SN., Jones, N., Buch, M., Jacobs, L., Perrett, R., et al. (2005) 'Non-myeloablative stem cell gene delivery effectively establishes long-term gene expression and mixed chimerism in immunocompetent mice'.34th Annual Meeting of the International-Society-for-Experimental-Hematology. Univ Glasgow, Glasgow, SCOTLAND. 30 - 2 August. ELSEVIER SCIENCE INC. pp. 41 - 42. ISSN: 0301-472X

Conference paper

Waddington, SN., Kramer, MG., Hernandez-Alcoceba, R., Buckley, SM., Themis, M., Coutelle, C. and et al. (2005) 'In utero gene therapy: Current challenges and perspectives'. Molecular Therapy, 11 (5). pp. 661 - 676. ISSN: 1525-0016

Journal article

Al-Allaf, F., Tolmachov, O., Themis, M. and Coutelle, C. (2005) 'Accurate size gauging of ExoIII/S1-generated deletions by PCR analysis of ligation mixtures'. Anal Biochem, 339 (2). pp. 348 - 350. ISSN: 0003-2697

Journal article

Themis, M., Bennett, PR., Mehmet, H., Waddington, SN. and Buckley, SM. (2005) 'The development of a mouse model to study the effect of uterine infection on preterm labour and fetal outcome.'.52nd Annual Meeting of the Society-for-Gynecologic-Investigation. Los Angeles, CA. 23 - 26 March. ELSEVIER SCIENCE INC. pp. 259A - 259A. ISSN: 1071-5576

Conference paper

Weisz, B., David, A., Peebles, D., Gregory, L., Perocheau, D., Waddington, S., et al. (2005) 'Targeting the fetal respiratory muscles for prenatal gene therapy for Duchenne muscular dystrophy'.25th Annual Meeting of the Society-for-Maternal-Fetal-Medicine. Reno, NV. 7 - 12 February. MOSBY-ELSEVIER. pp. S22 - S22. ISSN: 0002-9378

Conference paper

David, A., Weisz, B., Peebles, D., Roubliova, X., Perocheau, D., Themis, M., et al. (2005) 'Ultrasound guided placement of an occlusive balloon in the trachea of fetal sheep'.25th Annual Meeting of the Society-for-Maternal-Fetal-Medicine. Reno, NV. 7 - 12 February. MOSBY-ELSEVIER. pp. S166 - S166. ISSN: 0002-9378

Conference paper

Themis, M., Waddington, SN., Schmidt, M., von Kalle, C., Wang, Y., Al-Allaf, F., et al. (2005) 'Oncogenesis following delivery of a nonprimate lentiviral gene therapy vector to fetal and neonatal mice.'. Molecular Therapy, 12 (4). pp. 763 - 771. ISSN: 1525-0016

Journal article

Waddington, SN., Nivsarkar, MS., Mistry, AR., Buckley, SMK., Kemball-Cook, G., Mosley, KL., et al. (2004) 'Permanent phenotypic correction of hemophilia B in immunocompetent mice by prenatal gene therapy'. BLOOD, 104 (9). pp. 2714 - 2721. ISSN: 0006-4971

Journal article

Gregory, LG., Waddington, SN., Holder, MV., Mitrophanous, KA., Buckley, SM., Mosley, KL., et al. (2004) 'Highly efficient EIAV-mediated in utero gene transfer and expression in the major muscle groups affected by Duchenne muscular dystrophy'. Gene Therapy, 11 (14). pp. 1117 - 1125. ISSN: 0969-7128

Journal article

Themis, M., Gregory, LG., Waddington, SN., Holder, MV., Mitrophanous, KA., Buckley, SMK., et al. (2004) 'The fetal approach: A novel therapy for the treatment of musculo-skeletal disease'.7th Annual Meeting of the American-Society-of-Gene-Therapy. Minneapolis, MN. 2 - 6 June. ACADEMIC PRESS INC ELSEVIER SCIENCE. pp. S91 - S91. ISSN: 1525-0016

Conference paper

Bigger, BW., Siapati, EK., Mistry, A., Waddington, SN., Nivsarkar, MS., Holder, MV., et al. (2004) 'Induction of immune tolerance and phenotypic rescue of hemophilic mice by stem cell mediated gene transfer'.7th Annual Meeting of the American-Society-of-Gene-Therapy. Minneapolis, MN. 2 - 6 June. ACADEMIC PRESS INC ELSEVIER SCIENCE. pp. S64 - S64. ISSN: 1525-0016

Conference paper

Ma, YI., Tolmachov, O., Themis, M., Spohr, H., Kienast, Y., Coutelle, C. and et al. (2004) 'Field action potential activation and propagation in cocultured cardiac myocytes and Cx43 transduced skeletal myoblasts in a multi-electrode array'.Annual Conference of the British-Cardiac-Society. Manchester, ENGLAND. 24 - 27 May. B M J PUBLISHING GROUP. pp. A37 - A37. ISSN: 1355-6037

Conference paper

Waddington, SN., Buckley, SM., Bernloehr, C., Bossow, S., Ungerechts, G., Cook, T., et al. (2004) 'Reduced toxicity of F-deficient Sendai virus vector in the mouse fetus'. Gene Ther, 11 (7). pp. 599 - 608. ISSN: 0969-7128

Journal article

Bergau, A., Gregory, L., Waddington, S., Harbottle, R., Lawrence, L., Coutelle, C. and et al. (2004) 'Comparative analysis of the human cytokeratin K18 promoter with the CMV promoter by hydrodynamic injection of adult MF-1 mice'.1st Annual Conference of the British-Society-for-Gene-Therapy. Keble Coll, Oxford, ENGLAND. 28 - 30 March. JOHN WILEY & SONS LTD. pp. S5 - S6. ISSN: 1099-498X

Conference paper

Bigger, BW., Siapati, KE., Mistry, A., Waddington, SN., Nivsarkar, MS., Holder, MV., et al. (2004) 'Induction of immune tolerance and partial phenotypic correction of haermophiliac mice by lentiviral gene transfer of human factor IX to haematopoietic stem cells'.1st Annual Conference of the British-Society-for-Gene-Therapy. Keble Coll, Oxford, ENGLAND. 28 - 30 March. JOHN WILEY & SONS LTD. pp. S15 - S15. ISSN: 1099-498X

Conference paper

Holder, MV., Waddington, SN., Gregory, LG., Kramer, MG., Prieto, J., Mitrophanous, K., et al. (2004) 'Comparison of gene expression from liver specific promoter/enhancer combinations in the context of a lentiviral backbone'.1st Annual Conference of the British-Society-for-Gene-Therapy. Keble Coll, Oxford, ENGLAND. 28 - 30 March. JOHN WILEY & SONS LTD. pp. S9 - S9. ISSN: 1099-498X

Conference paper

Gregory, LG., Waddington, SN., Holder, M., Mitrophanous, KA., Buckley, SMK., Ellard, FM., et al. (2004) 'Pseudotyped lentiviral vectors: Toward an applicability for in utero treatment of Duchenne Muscular Dystrophy'.1st Annual Conference of the British-Society-for-Gene-Therapy. Keble Coll, Oxford, ENGLAND. 28 - 30 March. JOHN WILEY & SONS LTD. pp. S18 - S18. ISSN: 1099-498X

Conference paper

Chan, J., O'Donoghue, K., Kennea, N., de la Fuente, J., Waddington, S., Themis, M., et al. (2004) 'Human fetal mesenchymal stem cells for intrauterine cellular therapy'.1st Annual Conference of the British-Society-for-Gene-Therapy. Keble Coll, Oxford, ENGLAND. 28 - 30 March. JOHN WILEY & SONS LTD. pp. S17 - S17. ISSN: 1099-498X

Conference paper

Themis, M. (2004) 'An in vitro hprt locus insertion mutagenesis assay'.1st Annual Conference of the British-Society-for-Gene-Therapy. Keble Coll, Oxford, ENGLAND. 28 - 30 March. JOHN WILEY & SONS LTD. pp. S37 - S37. ISSN: 1099-498X

Conference paper

Waddington, SN., Nivsarkar, M., Mistry, A., Buckley, SMK., Kemball-Cook, G., Mosley, KL., et al. (2004) 'Permanent phenotypic correction of Haemophilia B in immunocompetent mice by prenatal gene therapy'.1st Annual Conference of the British-Society-for-Gene-Therapy. Keble Coll, Oxford, ENGLAND. 28 - 30 March. WILEY-BLACKWELL. pp. S17 - S17. ISSN: 1099-498X

Conference paper

Nivsarkar, MS., Nathwani, A., Mosley, K., Davies, N., Gregory, LG., David, AL., et al. (2004) 'Testosterone induced increase in transgene expression in vivo using Adenoviral Gene Delivery Vectors'.1st Annual Conference of the British-Society-for-Gene-Therapy. Keble Coll, Oxford, ENGLAND. 28 - 30 March. WILEY-BLACKWELL. pp. S12 - S13. ISSN: 1099-498X

Conference paper

Weisz, B., David, AL., Peebles, DM., Gregory, L., Perocheau, D., Themis, M., et al. (2004) 'Targeting the fetal gut for prenatal gene therapy.'.51st Annual Meeting of the Society-for-Gynecologic-Investigation. Houston, TX. 24 - 27 March. ELSEVIER SCIENCE INC. pp. 182A - 182A. ISSN: 1071-5576

Conference paper

Alison, MR., Vig, P., Russo, F., Bigger, BW., Amofah, E., Themis, M. and et al. (2004) 'Hepatic stem cells: From inside and outside the liver?'. Cell Proliferation, 37 (1). pp. 1 - 21. ISSN: 0960-7722

Journal article

Waddington, SN., Buckley, SMK., Gregory, LG., Themis, M., Coutelle, C. and Kennea, NL. (2004) 'Fetal and neonatal gene therapy: Benefits and pitfalls'.2nd European Conference and Practical Course on Towards Clinical Gene Therapy - Preclinical Gene Transfer Assessment. Univ Autonoma Barcelona, Fac Vet, Bellaterra, SPAIN. 1 - 14 February. Springer Science and Business Media LLC. pp. S92 - S97. ISSN: 0969-7128

Conference paper

Mellor, N., Themis, M., Selden, C., Jones, M. and Hodgson, HJF. (2004) 'Characteristics of murine histidinaemia and its potential for genetic manipulation'. Liver International, 24 (4). pp. 354 - 360. ISSN: 1478-3223

Journal article

Peebles, D., Gregory, LG., David, A., Themis, M., Waddington, SN., Knapton, HJ., et al. (2004) 'Widespread and efficient marker gene expression in the airway epithelia of fetal sheep after minimally invasive tracheal application of recombinant adenovirus in utero'. Gene Therapy, 11 (1). pp. 70 - 78. ISSN: 0969-7128

Journal article