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Elucidating the Neuropsychological and Genomic Mechanisms Underlying Psychosis in Older Adults with and Without Dementia

Psychosis, broadly defined by delusions and hallucinations, is a feature of many clinical conditions.

Perhaps the best known of these is schizophrenia but psychosis also occurs in the context of dementia and psychotic-like experiences can occur in older adults without any known medical conditions. This project will focus on psychosis and psychotic experiences in older adults with and without dementia.

Through advanced statistical modeling of existing longitudinal cognitive, neuropsychiatric and genomic data this project will generate new insights into the role of psychosis in cognitive aging and dementia. Specifically the findings could identify new treatment targets and risk factors for cognitive decline and symptoms of dementia.

How to apply

If you are interested in applying for the above PhD topic please follow the steps below:

  1. Contact the supervisor by email or phone to discuss your interest and find out if you would be suitable. Supervisor details can be found on this topic page. The supervisor will guide you in developing the topic-specific research proposal, which will form part of your application.
  2. Click on the "Apply here" button on this page and you will be taken to the relevant PhD course page, where you can apply using an online application.
  3. Complete the online application indicating your selected supervisor and include the research proposal for the topic you have selected.

Good luck!

This is a self-funded topic

Brunel offers a number of funding options to research students that help cover the cost of their tuition fees, contribute to living expenses or both. The UK Government is also offering Doctoral Student Loans for eligible students, and there is some funding available through the Research Councils. Many of our international students benefit from funding provided by their governments or employers. Brunel alumni enjoy tuition fee discounts of 15%.

Meet the Supervisor

Byron Creese

Research Summary I am a translational researcher whose research focuses on neuropsychiatric symptoms in dementia and late-life onset neuropsychiatric symptoms as markers of neurodegenerative disease. My research employs a variety of approaches from psychology to genomics and epidemiology to investigate the disease mechanisms and clinical consequences of these symptoms. My work draws on extensive experience with large longitudinal datasets, proxy-reported and self-reported outcomes, and complex statistical modelling. I have published numerous research articles in peer-reviewed journals and presented research at national and international conferences. In addition to my research, I am actively involved in mentoring students and am committed to fostering the next generation of dementia researchers. I received my PhD from King's College London and completed a postdoctoral research there and at University of Exeter. Consultancy I also provide research-led consultancy to MedTech and pharmaceutical organisations, delivered via the University https://www.brunel.ac.uk/business/Research-and-development/Consultancy). My expertise lies in real-world evidence (RWE), behavioural and cognitive outcomes, and neuropsychiatric symptoms, with a particular focus on ageing, dementia, and mental health. I work with industry teams to generate and interpret evidence that supports product development and clinical strategy. I support MedTech and Pharma partners with: Study design and evidence strategy for observational and longitudinal research Advanced analysis of real-world and patient-reported outcomes data Interpretation of behavioural, neuropsychiatric, and cognitive endpoints Evidence to support value propositions, payer conversations, and regulatory engagemeny All consultancy is undertaken via Brunel University London.