Research profile
The overall aim of the Synthetic Biology is to address major environmental, health and societal challenges by engineering biological systems such that they display functions that do not exist in nature, as well as re-designing existing biological systems so that they perform new functions. Our research focuses on three key areas of activity.
- Gene therapy: Some diseases and disorders happen because certain genes work incorrectly or no longer work at all. We are designing therapeutic interventions for human diseases and disorders by developing the technologies to correct defective genes. Our current projects within this area look at vector development for effective gene therapy, assessing and avoiding the risks of gene therapy (genotoxicity) and using the technologies of gene therapy to give new insights into cancer development.
- Microbial bioengineering: The most exploitable and engineerable organisms are bacteria, so we want to harness their capacity and diversity to create white technologies –those which cause no harm. Our research uses integrated genomics strategies to direct bacterial engineering for a number of translational applications. We look at possible ways to create novel bacteria –bacteria that can produce clean proteins, for example, or bacteria that can improve the performance of cement. Using bioengineered microbes, we look at ways to degrade environmental pollutants; generate products using alternatives to petrochemicals; and reuse waste biomaterials from biomass and biodiesel manufacture. There are even investigations within our theme into ways of addressing antibiotic resistance in medically important bacteria. We are exploring other areas, and are open to developing new lines of research that will make the best use of the strain and widely applicable tools for strain assessment and development, especially when they are directed at projects that have sustainability as part of what they seek to achieve.
- Computer sciences, statistics and maths: We are working on data analysis, bioinformatics, and system modelling to inform synthetic system 30 design and efficient laboratory engineering strategies. These outcomes will support our other strands of research.
Find out about the exciting research we do: browse profiles of our experts, discover the research groups and their inspirational research activities you too could be part of. We’ve also made available extensive reading materials published by our academics and PhD students.
Learn more about research in this area.
Browse the work of subject-relevant research groups
Find a supervisor
Our researchers create knowledge and advance understanding, and equip versatile doctoral researchers with the confidence to apply what they have learnt for the benefit of society. Find out more about working with the Supervisory Team.
You are welcome to approach your potential supervisor directly to discuss your research interests. Search for expert supervisors for your chosen field of research.
PhD topics
While we welcome applications from students with a clear direction for their research, we are providing you with some ideas for your chosen field of research:
- A systems approach to plastic waste valorisation, supervised by Kok Siew Ng
- Decision making for stratified medicine life cycle, supervised by Yang Yang
- Decision making for stratified medicine life cycle, supervised by Yang Yang
- Deep Learning for Medical Imaging, supervised by Yongmin Li
- Deep learning-based autonomous diagnosis of gastrointestinal tract cancers, supervised by Md Nazmul Huda
- Developing RAC1B-targeting therapies to improve the treatment outcomes for breast cancer, supervised by Ahmet Ucar
- Developing Sustainable Decarbonised Polygeneration System Concept for the Production of Hydrogen, Chemicals and Energy, supervised by Kok Siew Ng
- Development of a miniature capsule robot for capsule endoscopy, supervised by Md Nazmul Huda
- Development of a novel PCR-based assay to evaluate CAR-T safety using a human-based genotoxicity model, supervised by Michael Themis
- Elucidating the mechanisms of early-stage breast cancer initiation, supervised by Ahmet Ucar
- Health data analysis to identify the role of gene and environment in risk of cardiovascular diseases, supervised by Raha Pazoki
- Hypoxia-driven macrophage modulation in cancer and its impact on T cell immunotherapy, supervised by Doreen Lau
- Identification of determinants of sudden cardiac death and arrhythmias using population studies, supervised by Raha Pazoki
- Individual histone modification roles in regulation of transcription and cell decision-making, supervised by Cristina Correia Antunes Pina
- Machine learning approaches in health data science for risk prediction of cardiovascular diseases, supervised by Raha Pazoki
- Multi-omics data analysis for critical disease prediction, supervised by Yang Yang
- Precision control of Nano-fuel production, supervised by Yang Yang
- Sustainable Aviation Fuel Production from Biomass and Waste using a Biorefinery Approach, supervised by Kok Siew Ng
- Sustainable production of functional materials from waste, supervised by Abhishek Lahiri
- Sustainable production of Vitamin K1, supervised by Dale McClure
- The role of PE/PPE proteins in tuberculosis, supervised by Anthony Tsolaki
- The sustainability of hydrogen production for future energy uses, supervised by Colin Axon and Peter Hewitson
Research journey
This course can be studied undefined undefined, starting in undefined.
Find out about what progress might look like at each stage of study here: Research degree progress structure.
Research support
Research support
Excellent research support and training
The Graduate School provides a range of personal, professional and career development opportunities. This includes workshops, online training, coaching and events, to enable you to enhance your professional profile, refine your skills, and plan your next career steps as part of the Researcher Development Programme. The researcher development programme (RDP) offers workshops and seminars in a range of areas including progression, research management, research dissemination, and careers and personal development. You will also be offered a number of online, self-study courses on BBL, including Research Integrity, Research Skills Toolkit, Research Methods in Literature Review and Principles of Research Methods.
Library services
Brunel's Library is open 24 hours a day, has 400,000 books and 250,000 ebooks, and an annual budget of almost £2m. Subject information Specialists train students in the latest technology, digital literacy, and digital dissemination of scholarly outputs. As well as the physical resources available in the Library, we also provide access to a wealth of electronic resources. These include databases, journals and e-books. Access to these resources has been bought by the Library through subscription and is limited to current staff and students.
Dedicated research support staff provide guidance and training on open access, research data management, copyright and other research integrity issues.
Find out more: Brunel Library
Careers and your future
You will receive tailored careers support during your PhD and for up to three years after you complete your research at Brunel. We encourage you to actively engage in career planning and managing your personal development right from the start of your research, even (or perhaps especially) if you don't yet have a career path in mind. Our careers provision includes online information and advice, one-to-one consultations and a range of events and workshops. The Professional Development Centre runs a varied programme of careers events throughout the academic year. These include industry insight sessions, recruitment fairs, employer pop-ups and skills workshops.
In addition, where available, you may be able to undertake some paid work as we recognise that teaching and learning support duties represent an important professional and career development opportunity.
UK entry requirements
The general University entrance requirement for registration for a research degree is normally a First or Upper Second Class Honours degree (1st or 2:1).
An interview will be required as part of the admissions process and will be conducted by at least two academic staff members remotely via MS Teams, Zoom, or face to face.
Applicants will be required to submit a personal statement and a research statement.
Please contact your proposed supervisor, where possible, to receive feedback and guidance on your research statement before submitting it. Learn how to prepare a research statement here.
EU and International entry requirements
English language requirements
- IELTS: 7 (min 6 in all areas)
- Pearson: 64 (59 in all subscores)
- BrunELT: 68% (58% in all areas)
- TOEFL: 98 overall (min 20)
You can find out more about the qualifications we accept on our English Language Requirements page.
Should you wish to take a pre-sessional English course to improve your English prior to starting your degree course, you must sit the test at an approved SELT provider for the same reason. We offer our own BrunELT English test and have pre-sessional English language courses for students who do not meet requirements or who wish to improve their English. You can find out more information on English courses and test options through our Brunel Language Centre.
Please check our Admissions pages for more information on other factors we use to assess applicants. This information is for guidance only and each application is assessed on a case-by-case basis. Entry requirements are subject to review, and may change.
Fees and funding
2024/5 entry
International
£23,615 full-time
£11,805 part-time
UK
£4,786 full-time
£2,393 part-time
Fees quoted are per year and are subject to an annual increase.
Some courses incur additional course related costs. You can also check our on-campus accommodation costs for more information on living expenses.
Brunel offers a number of funding options to research students that help cover the cost of their tuition fees, contribute to living expenses or both. Recently the UK Government made available the Doctoral Student Loans of up to £25,000 for UK and EU students and there is some funding available through the Research Councils. Many of our international students benefit from funding provided by their governments or employers. Brunel alumni enjoy tuition fee discounts of 15%.