Professor John P Sumpter

Professor in Ecotoxicology

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Room: Halsbury Building 128
Brunel University
Uxbridge
UB8 3PH
United Kingdom
Tel: +44 (0)1895 266303
Email: john.sumpter@brunel.ac.uk

About John

I head a research group focussed on chemicals in the aquatic environment, and their effects on fish. I discovered endocrine disruption in fish, caused by estrogenic chemicals entering rivers in effluents from sewage treatment works. My research group currently consists of 3 post-doctoral fellows and four Ph.D. students. Our main focus has broadened from just estrogenic chemicals, and now includes other human pharmaceuticals present in rivers, such as beta-blockers, other steroid hormones (e.g. progestogens, glucocorticoids), and anti-cancer drugs. Our research ranges from detailed molecular studies of the mechanisms of action of these chemicals through to ecological studies on fish populations.

Qualifications

  • 1973: First-class Honours Degree in Zoology/Marine Zoology from University College of North Wales, Bangor.
  • 1977: PhD from University College of North Wales, Bangor.
  • 1987: Elected Fellow of the Institute of Biology.
  • 1991: Awarded DSc from University of Wales
  • 2004: Made ‘Distinguished Professor’ of Brunel University

Career

  • 1976-78: Post-doctoral Fellow at University College of North Wales, Bangor.
  • 1978-87: Lecturer in Applied Biology, Brunel University.
  • 1987-91: Reader in Department of Biology and Biochemistry, Brunel University.
  • 1991-2005: Professor in Department of Biology and Biochemistry, Brunel University, and Head of the Ecotoxicology Research Group.
  • 2001-03: Head of Department of Biological Sciences, Brunel University
  • 2004: Dean of the Faculty of Life Sciences, Brunel University
  • 2005-present: Professor in Institute for the Environment, Brunel University
  • 2007-2011: Head of Institute for the Environment, Brunel University.

Research

Research Interests

Research Activity

When I came to Brunel University in 1978, the University had a very low research profile; only a few staff were active in research. Over the next twenty years, I built up a large research group, consisting of twenty staff at its peak.

My research can be broken down into two related, though somewhat separate, fields. One, which I began with my PhD, and have continued ever since, is concerned with the hormonal control of fish reproduction (and, to a lesser extent, stress). The other is concerned with endocrine disruption; it is in this area that I now concentrate most of my efforts, and for which I have an international reputation.

Membership of Learned Societies

  • Society for Experimental Biology
  • The Fisheries Society of the British Isles
  • European Society for Comparative Endocrinology
  • Society for the Study of Fertility
  • Society for Endocrinology
  • Society for the Study of Reproduction
  • SETAC

I have delivered talks at meetings organised by all of these societies, and at many other national and international meetings

Major Research Grants Awarded

  • Royal Society: Scientific investigation grant of £4,652 for the purchase of an automatic gamma-counter.
  • SERC: £30,430 from 1 October 1980 until 30 September 1983 for a study entitled ‘The characterization and physiological roles of peptides derived from pro-opiomelanocortin in fishes’ (in collaboration with Dr P J Lowry, St Bartholomew’s Hospital).
  • MAFF: £18,050 from 1 January 1981 until 31 March 1984 for a study entitled ‘The purification, characterization and physiological roles of salmonid gonadotrophin.’
  • SERC: £39,340 from 1 October 1984 until 31 September 1987 for a study entitled ‘Ovarian uptake of vitellogenin in the Rainbow Trout’ in collaboration with Dr N R Bromage, University of Aston).
  • Royal Society: £8,520 from 1 May 1984 until 31 December 1984 from the Anglo-Canadian exchange scheme to enable me to spend nine months on sabbatical leave in the laboratory of Dr E M Donaldson in Vancouver.
  • SERC: £18,060 from 1 January 1987 to 31 December 1987 for a study entitled ‘Hormonal control of growth and sea-water adaptation in rainbow trout’ (in collaboration with Dr Vic Bye, MAFF, Lowestoft, though he was not formally named on the grant).
  • MAFF: £37,000 from 1 December 1986 to 31 March 1987 for a study entitled “The effects of environmental stress on the physiology of growth in trout”. (Awarded jointly to Dr A D Pickering, Freshwater Biological Association, Windermere, and myself).
  • Department of the £83,142 from 1 January 1988 to 30 June 1990 for a study entitled “Effects of Environment: trace organics on coarse fish.
  • MAFF: £23,508 from 1 January 1989 to 31 December 1989 for a study entitled “The induction and metabolic demands of vitellogenin synthesis in carp”.
  • EC: £60,000 from 1 June 1990 to 31 May 1992 from the Fisheries Directorate to support a French Post-doctoral Fellow.
  • Department of the £146,025 from 1 October 1991 to 31 March 1995 for a study entitled “Effects of Environment: trace organics on coarse fish: Phase 2”.
  • AFRC: £98,000 from 1 September 1991 to 31 August 1994 for a study entitled "Determination of the physiological function, or functions, of somatolactin, a new member of the growth hormone/prolactin family in trout”.
  • MAFF: £65,597 from 1 June 1992 to 31 May 1995 for a field study of the effects of oestrogens in effluent on fish.
  • EC: £130,000 from 1 November 1993 to 31 October 1996 for a study entitled “Egg quality determinants of teleost fish”.
  • NRA: £142,916 from 1 December 1993 to 31 March 1997 for a study entitled “Identification of estrogenic substances in STW effluent”.
  • NERC: £138,418 from 1 March 1994 to 28 February 1997 for a study entitled “Effects of alkylphenols and related chemicals on gonad development, sex determination, and gamete quality of trout”.
  • BBSRC: £57,540 from 1 September 1994 to 31 August 1995 for a study entitled “Studies of somatolactin in fish and higher vertebrates”.
  • BBSRC: £127,892 from 1 January 1995 to 31 December 1997 for a study entitled “Molecular characterization of the vitellogenin receptor and the dynamics of its expression”, (with Dr C R Tyler).
  • ECETOC: £165,000 from 1 April 1995 to 31 March 1998 for studies on the oestrogenic properties of chemicals.
  • European Union: 97,622 ECU for a study from 1 January 1995 to 31 December 1996 for a study entitled “Molecular characterization of the vitellogenin receptor and control of its expression”.
  • NERC: £250,000 from 1 April 1995 to 31 March 2000 for a study entitled “Oestrogenic chemicals in the aquatic environment and their effects on fish”.
  • NERC: £75,283 from 1 October 1995 to 30 September 1997 for a study entitled “Oestrogenic activity of phthalates”.
  • Brunel University: £200,000 from 1 September 1995 to 31 August 2000, as matching funds to complement the NERC grant of £250,000 (see above).
  • European Union: 90,000 ECU from 1 April 1996 to 31 March 1998 for a study entitled “Male reproductive health and environmental chemicals” (part of a large project).
  • European Union: 105,000 ECU from 1 April 1996 to 31 March 1999, for a study entitled “Environmental halogenated aromatic hydrocarbons and estrogens: mechanism of action, interactions, and test-system development” (part of a large project).
  • Wellcome Trust: £58,038 from 1 September 1996 to 31 August 1999 for a study entitled “Effects of exposure to oestrogenic xenobiotics during early development on the expression of genes controlling sexual development” (with Drs Tyler and Rand-Weaver).
  • Environment Agency: £84,000 from 1 October 1996 to 30 September 1999 for the support of two studentships in the area of endocrine disruption (with Dr Tyler)
  • An industrial Company: £79,400 from 1 August 1996 to 31 July 1998 for a study of some industrial chemicals.
  • European Union £78,540 from 1 January 1998 to 31 December 1999 for a study entitled 'Do environmental estrogens (EEs) disrupt the neuro-endocrine regulation of reproduction in fish?'
  • Dept of Environment: £60,000 from 1 February 1998 to 31 January 2000 for a study entitled Transport and the "Endocrine disruption in the gudgeon". (with Dr Tyler). Regions
  • NERC: £186,145 from 1 July 1998 to 30 June 2001 for a study entitled "Reproductive capabilities of wild intersex fish" (with Dr C Tyler).
  • HEFCE: £51,000 (plus matching funds from Brunel University) to refurbish a laboratory.
  • Brunel University: £68,000 to establish a Fish Ecotoxicology Unit
  • BBSRC: £148,752 from 1 June 1998 to 31 May 2001 for a study entitled "Molecular characterization and developmental expression of enzymes mediating yolk processing (with Dr C Tyler).
  • CEFIC (the European Chemicals Industries £122,195 from 1 September 1998 to 31 August 2000 for a study entitled ") An ecological study to assess Bisphenol-A as an environmental oestrogen."
  • EMSG (an industry consortium £185,906 from 1 October 1998 to 30 September 2003 for a study) “Joint programme on endocrine disruptors in the aquatic environment”.
  • An industrial Company: £39,700 for one year from 16 November 1998 for a study entitled “Endocrine activity of landfill leachate”.
  • European Union: £120,000 from 1 January 1999 to 31 December 2001 for a study entitled “Community Programme of research on environmental hormones and endocrine disruptors” (COMPREHEND).
  • DETR: £132,048 from 1.8.2001-31.2.2004 for a study entitled “A search for evidence of endocrine disruption in top predator fish”.
  • European Union: £372,000 (538,903 Euros) from 1.12.01 to 30.11.04, for a study entitled “Analyzing combination effects of oestrogenic chemicals. This is part of a larger project (ACE), total budget 2.4 million Euros, which I co-ordinate.
  • European Union: £208,000 (322,960 Euros) from 1.12.02 to 30.11.06 for a study entitled “Endocrine Disruptors: Exploring novel endpoints, exposure, low dose and mixture effects in human, aquatic wildlife and laboratory animals”. This was part of a much larger project (EDEN), which has a total budget of 10.8 million Euros.
  • AstraZeneca/Pfizer: £92,610 from 1.3.04 to 28.2.06 for a study entitled “Physiological Responses of Fish to Pharmaceuticals”.
  • European Union: About £180,000 (290,000 Euros) from 1.9.04 to 31.8.07 for a study entitled “Environmental Risk Assessment of Pharmaceuticals”. This was part of a large project (ERAPharm).
  • NERC: £237,517 from 1.1.06 to 31.12.09 for a study entitled “Confounding Factors in the Risk Assessment of mixtures of estrogenic chemicals”
  • DEFRA: £323,400 from 1.1.06 to 31.12.08 for a study entitled “Influence of endocrine disruption on reproduction in roach”.
  • AstraZeneca: £50,540 from 1.3.06 to 28.2.07 for a continuation of the study “Physiological Responses of Fish to Pharmaceuticals”.
  • GlaxoSmithKline (GSK): £100,000 from 1.5.07 to 30.4.2010 for a project entitled “Research on pharmaceuticals in the environment”
  • DEFRA: £230,000 from 1.11.08 to 31.10.10 for a study entitled “Intelligent Ecotoxicology: progestogens as a test case”.
  • CEFAS: £64,000 from 1/1/09 to 31/12/09 for a study entitled “Validating a sexual development test using the 3-spined stickleback”.

Total value of Grants raised while at Brunel: approximately £5million.

Collaboration with Industry

Much of the research done by the Ecotoxicology Research Group is of considerable interest and relevance to many sectors of industry. This is particularly true of our work on persistent man-made chemicals in the environment which have the ability to mimic endogenous hormones, and thus (potentially) disrupt endocrine-mediated physiological processes, such as reproduction.

Some of the Group’s work is funded by industry, both via collective organisations such as the European Centre for the Ecotoxicology and Toxicology of Chemicals (ECETOC) and by industrial companies (including a number of the world’s largest multinationals). We also have a major ongoing collaboration with AstraZeneca, which links two of their main laboratories (the Environment Laboratory in Brixham and the Central Toxicology Laboratory at Alderley Edge) with my Ecotoxicology Research Group at Brunel.

Research Supervision

My first PhD student was awarded her degree in 1983. Since then, I have successfully supervised a further 25 full-time PhD students, plus two external PhD students, and 3 M.Phil. students. Presently, I am supervising 1 M.Phil. student, 2 PhD students and 4 post-doctoral fellows.

Postdoctoral Researchers

Postgraduate Researchers

  • Ms Katie Aoki
  • Mr Luigi Margiotta-Casaluci
  • Mr Kugathas Subramaniam

Teaching

I have been a University teacher since 1978, when I came to Brunel University. I attended an induction course, which had a strong emphasis on teaching, upon arrival. Since then, I have delivered between 40 and 70 lectures each year, held seminars (about 10 per year), and designed and run practical classes to complement my lecture courses (between 8 and 20 practicals per year). Student feedback, obtained primarily by anonymous questionnaires, has been collected each year, and used to change and improve the courses in subsequent years. In general, this feedback has been very positive.

Until recently, my main teaching had covered the area of Human and Animal Physiology (i.e. respiration, circulation, endocrinology, reproduction, etc.). For over 15 years, I taught a final-year course in Animal Reproduction, but more recently, as my research interests in environmental science grew, I replaced it with courses in Ecotoxicology, Biodiversity and Environmental Risk Assessment. These courses have been very well received by students, primarily, I think, because of the topicality of the subjects. I have introduced a number of modern teaching approaches into these courses, including group project work and presentations.

I also supervised between 3 and 6 final-year research projects each year, for twenty-five years. Some of the students have produced results which have been included in research papers (and hence the students have been authors), and many have gone on to do research (usually as PhD students) in the areas covered by their projects. I currently supervise students doing their MSc dissertations.

Between 1996 and 2001, I chaired the Teaching Policy Group within the Department of Biological Sciences. This Group was established primarily to ensure that teaching was not adversely affected when four senior staff (all with very considerable teaching experience) retired simultaneously, and were replaced by younger, more junior staff. Since transferring to the Institute for the Environment, I have played a major role in designing and developing Masters Courses in environmental science.

External Duties

  • Advisor to Department of Environment, Food and Rural Affairs (DEFRA) on chemicals policy
  • Reviewer of research grants and scientific papers for many organisations
  • Member of the Editorial Advisory Board of the prestigious journal “Environmental Science and Technology”
  • Visiting Professor of the Centre for Ecology and Hydrology (CEH)
  • External examiner of PhD’s for a large number of universities, both within the UK and abroad

Publications

Publications

Journal Papers

(2012) Kugathas, S., Williams, RJ. and Sumpter, JP., Prediction of environmental concentrations of glucocorticoids: The River Thames, UK, as an example, Environment International 40 (1) : 15- 23

(2011) Touraud, E., Roig, B., Sumpter, JP. and Coetsier, C., Drug residues and endocrine disruptors in drinking water: Risk for humans?, International Journal of Hygiene and Environmental Health 214 437- 441

(2011) Giltrow, E., Eccles, PD., Hutchinson, TH., Sumpter, JP. and Rand-Weaver, M., Characterisation and expression of β1-, β2- and β3-adrenergic receptors in the fathead minnow (Pimephales promelas), General and Comparative Endocrinology 173 (3) : 483- 490 Download publication

(2011) Brian, JV., Beresford, N., Margiotta-Casaluci, L. and Sumpter, JP., Preliminary data on the influence of rearing temperature on the growth and reproductive status of fathead minnows Pimephales promelas, Journal of Fish Biology 79 (1) : 80- 88 Download publication

(2011) Aoki, KA., Harris, CA., Katsiadaki, I. and Sumpter, JP., Evidence suggesting that di-n-butyl phthalate has antiandrogenic effects in fish, Environmental Toxicology and Chemistry 30 (6) : 1338- 1345 Download publication

(2011) Beresford, N., Brian, JV., Runnalls, TJ., Sumpter, JP. and Jobling, S., Estrogenic activity of tropical fish food can alter baseline vitellogenin concentrations in male fathead minnow (Pimephales promelas), Environmental Toxicology and Chemistry 30 (5) : 1139- 1145 Download publication

(2011) Harris, CA., Hamilton, PB., Runnalls, TJ., Vinciotti, V., Henshaw, A., Hodgson, D., Coe, TS., Jobling, S., Tyler, CR. and Sumpter, JP., The consequences of feminization in breeding groups of wild fish, Environmental Health Perspectives 119 (3) : 306- 311

(2011) Margiotta-Casaluci, L. and Sumpter, JP., 5α-Dihydrotestosterone is a potent androgen in the fathead minnow (Pimephales promelas), General and Comparative Endocrinology 171 (3) : 309- 318

(2011) Janna, H., Scrimshaw, MD., Williams, RJ., Churchley, J. and Sumpter, JP., From dishwasher to tap? Xenobiotic substances benzotriazole and tolyltriazole in the environment, Environmental Science and Technology 45 (9) : 3858- 3864

(2011) Fent, K. and Sumpter, JP., Progress and promises in toxicogenomics in aquatic toxicology: Is technical innovation driving scientific innovation?, Aquatic Toxicology 105 (Supplement 3-4) : 25- 39

(2011) Kugathas, S. and Sumpter, JP., Synthetic glucocorticoids in the environment: First results on their potential impacts on fish, Environmental Science and Technology 45 (6) : 2377- 2383

(2010) Runnalls, TJ., Margiotta-Casaluci, L., Kugathas, S. and Sumpter, JP., Pharmaceuticals in the aquatic environment: Steroids and anti-steroids as high priorities for research, Human and Ecological Risk Assessment 16 (6) : 1318- 1338

(2010) Paulos, P., Runnalls, TJ., Nallani, G., La Point, T., Scott, AP., Sumpter, JP. and Huggett, DB., Reproductive responses in fathead minnow and Japanese medaka following exposure to a synthetic progestin, Norethindrone, Aquatic Toxicology 99 (2) : 256- 262

(2010) Tarazona, JV., Escher, BI., Giltrow, E., Sumpter, J. and Knacker, T., Targeting the environmental risk assessment of pharmaceuticals: Facts and fantasies, Integrated Environmental Assessment and Management 6 (SUPPL. 1) : 603- 613

(2010) Scott, AP., Sumpter, JP. and Stacey, N., The role of the maturation-inducing steroid, 17,20β-dihydroxypregn-4-en-3-one, in male fishes: A review, Journal of Fish Biology 76 (1) : 183- 224

(2010) Owen, SF., Huggett, DB., Hutchinson, TH., Hetheridge, MJ., McCormack, P., Kinter, LB., Ericson, JF., Constantine, LA. and Sumpter, JP., The value of repeating studies and multiple controls: Replicated 28-day growth studies of rainbow trout exposed to clofibric acid, Environmental Toxicology and Chemistry 29 (12) : 2831- 2839

(2009) Giltrow, E., Eccles, PD., Winter, MJ., McCormack, PJ., Rand-Weaver, M., Hutchinson, TH. and Sumpter, JP., Chronic effects assessment and plasma concentrations of the β-blocker propranolol in fathead minnows (Pimephales promelas), Aquatic Toxicology 95 (3) : 195- 202 Download publication

(2009) Jürgens, MD., Johnson, AC., Pottinger, TG. and Sumpter, JP., Do suspended sediments modulate the effects of octylphenol on rainbow trout?, Water Research 43 (5) : 1381- 1391

(2009) Hannah, R., D'Aco, VJ., Anderson, PD., Buzby, ME., Caldwell, DJ., Cunningham, VL., Ericson, JF., Johnson, AC., Parke, NJ., Samuelian, JH. and Sumpter, JP., Exposure assessment of 17α-ethinylestradiol in surface waters of the Uniter States and Europe, Environmental Toxicology and Chemistry 28 (12) : 2725- 2732

(2009) Brian, JV., Beresford, N., Walker, J., Pojana, G., Fantinati, A., Marcomini, A. and Sumpter, JP., Hypoxia does not influence the response of fish to a mixture of estrogenic chemicals, Environmental Science and Technology 43 (1) : 214- 218 Download publication

(2009) Sumpter, JP., Protecting aquatic organisms from chemicals: the harsh realities, Philosophical Transactions of the Royal Society A 367 (1904) : 3877- 3894

(2009) Johnson, AC., Acreman, MC., Dunbar, MJ., Feist, SW., Giacomello, AM., Gozlan, RE., Hinsley, SA., Ibbotson, AT., Jarvie, HP., Jones, JI., Longshaw, M., Maberly, SC., Marsh, TJ., Neal, C., Newman, JR., Nunn, MA., Pickup, RW., Reynard, NS., Sullivan, CA., Sumpter, JP. and Williams, RJ., The British river of the future: how climate change and human activity might affect two contrasting river ecosystems in England, Science of The Total Environment 407 (17) : 4787- 4798

(2009) Harris, CA., Brian, JV., Pojana, G., Lamoree, M., Booy, P., Marcomini, A. and Sumpter, JP., The influence of a surfactant, linear alkylbenzene sulfonate, on the estrogenic response to a mixture of (xeno)estrogens in vitro and in vivo, Aquatic Toxicology 91 (1) : 95- 98 Download publication

(2009) Owen, SF., Huggett, DB., Hutchinson, TH., Hetheridge, MJ., Kinter, LB., Ericson, JF. and Sumpter, JP., Uptake of propranolol, a cardiovascular pharmaceutical, from water into fish plasma and its effects on growth and organ biometry, Aquatic Toxicology 93 (4) : 217- 224

(2008) Brian, JV., Harris, CA., Runnalls, TJ., Fantinati, A., Pojana, G., Marcomini, A., Booy, P., Lamoree, M., Kortenkamp, A. and Sumpter, JP., Evidence of temperature-dependent effects on the estrogenic response of fish: Implications with regard to climate change, Science of The Total Environment 397 (1-3) : 72- 81 Download publication

(2008) Johnson, AC., Ternes, T., Williams, RJ. and Sumpter, JP., Assessing the concentrations of polar organic microcontaminants from point sources in the aquatic environment: measure or model?, Environmental Science and Technology 42 (15) : 5390- 5399

(2008) Winter, MJ., Lillicrap, AD., Caunter, JE., Schaffner, C., Alder, AC., Ramil, M., Ternes, TA., Giltrow, E., Sumpter, JP. and Hutchinson, TH., Defining the chronic impacts of atenolol on embryo-larval development and reproduction in the fathead minnow (Pimephales promelas), Aquatic Toxicology 86 (3) : 361- 369

(2008) Caldwell, DJ., Mastrocco, F., Hutchinson, TH., Lange, R., Heijerick, D., Janssen, C., Anderson, PD. and Sumpter, JP., Derivation of an aquatic predicted no-effect concentration for the synthetic hormone, 17α-ethinyl estradiol, Environmental Science and Technology 42 (19) : 7046- 7054

(2008) Johnson, AC., Jürgens, MD., Williams, RJ., Kümmerer, K., Kortenkamp, A. and Sumpter, JP., Do cytotoxic chemotherapy drugs discharged into rivers pose a risk to the environment and human health? An overview and UK case study, Journal of Hydrology 348 (1-2) : 167- 175

(2008) Gabriel, FLP., Routledge, EJ., Heidlberger, A., Rentsch, D., Guenther, K., Giger, W., Sumpter, JP. and Kohler, HPE., Isomer-specific degradation and endocrine disrupting activity of nonylphenols, Environmental Science and Technology 42 (17) : 6399- 6408

(2008) Sumpter, JP. and Johnson, AC., Reflections on endocrine disruption in the aquatic environment: from known knowns to unknown unknowns (and many things in between), Journal of Environmental Monitoring 10 (12) : 1476- 1485

(2008) Sumpter, JP., The ecotoxicology of hormonally active micropollutants, Water Science and Technology 57 (1) : 125- 130

(2007) Pash, S., Spooner, J. and Sumpter, JP., Albino common toads (Bufo bufo), Herpetological Bulletin (100) : 8- 11

(2007) Harris, CA., Routledge, EJ., Schaffner, C., Brian, JV., Giger, W. and Sumpter, JP., Benzotriazole is antiestrogenic in vitro but not in vivo, Environmental Toxicology and Chemistry 26 (11) : 2367- 2372 Download publication

(2007) Owen, SF., Giltrow, E., Huggett, DB., Hutchinson, TH., Saye, J., Winter, MJ. and Sumpter, JP., Comparative physiology, pharmacology and toxicology of beta-blockers: Mammals versus fish, Aquatic Toxicology 82 (3) : 145- 162

(2007) Sumpter, JP., Environmental effects of human pharmaceuticals, Drug Information Journal 41 (2) : 143- 147

(2007) Brian, JV., Harris, CA., Scholze, M., Kortenkamp, A., Booy, P., Lamoree, M., Pojana, G., Jonkers, N., Marcomini, A. and Sumpter, JP., Evidence of estrogenic mixture effects on the reproductive performance of fish, International Journal of Environmental Science and Technology 41 (1) : 337- 344 Download publication

(2007) Maunder, RJ., Matthiessen, P., Sumpter, JP. and Pottinger, TG., Impaired reproduction in three-spined sticklebacks exposed to ethinyl estradiol as juveniles, Biology of Reproduction 77 (6) : 999- 1006

(2007) Sumpter, JP. and Brian, JV., Mixtures of chemicals in water: implications of chemical legislation and environmental policy, The Journal of Water Law 18 (2) : 62- 65 Download publication

(2007) Spooner, J., Pash, S. and Sumpter, JP., Occurrence of an albino newt and albino Common toads (Bufo bufo) in the same garden pond, Herpetological Bulletin (100) : 11- 12

(2007) Runnalls, TJ., Hala, DN. and Sumpter, JP., Preliminary studies into the effects of the human pharmaceutical Clofibric acid on sperm parameters in adult Fathead minnow, Aquatic Toxicology 84 (1) : 111- 118

(2007) Maunder, RJ., Matthiessen, P., Sumpter, JP. and Pottinger, TG., Rapid bioconcentration of steroids in the plasma of three-spined stickleback Gasterosteus aculeatus exposed to waterborne testosterone and 17 beta-oestradiol, Journal of Fish Biology 70 (3) : 678- 690

(2007) Ankley, GT., Brooks, BW., Huggett, DB. and Sumpter, JP., Repeating history: Pharmaceuticals in the environment, Environmental Science and Technology 41 (24) : 8211- 8217

(2006) Sumpter, JP., Johnson, AC., Williams, RJ., Kortenkamp, A. and Scholze, M., Modeling effects of mixtures of endocrine disrupting chemicals at the river catchment scale, Environmental Science and Technology 40 (17) : 5478- 5489

(2006) Sumpter, JP. and Johnson, AC., Response to comment on "Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment", Environmental Science and Technology 40 (3) : 1086- 1087

(2005) Brian, JV., Harris, CA., Scholze, M., Backhaus, T., Booy, P., Lamoree, M., Pojana, G., Jonkers, N., Runnalls, T., Bonfà, A., Marcomini, A. and Sumpter, JP., Accurate prediction of the response of freshwater fish to a mixture of estrogenic chemicals, Environmental Health Perspectives 113 (6) : 721- 728 Download publication

(2005) Vine, E., Shears, J., van, AR., Tyler, CR. and Sumpter, JP., Endocrine (sexual) disruption is not a prominent feature in the pike (Esox lucius), a top predator, living in English waters, Environmental Toxicology and Chemistry 24 (6) : 1436- 1443

(2005) Sumpter, JP., Endocrine disrupters in the aquatic environment: An overview, Acta Hydrochimica et Hydrobiologica 33 (1) : 9- 16

(2005) Sumpter, JP. and Johnson, AC., Lessons from endocrine disruption and their application to other issues concerning trace organics in the aquatic environment, Environmental Science and Technology 39 (12) : 4321- 4332

(2004) Hermens, JLM., Ankley, GT. and Sumpter, JP., Ecotoxicology - a multidisciplinary, problem-driven science, Environmental Science and Technology 38 (23) : 446A- 447A

(2004) Beresford, N., Jobling, S., Williams, R. and Sumpter, JP., Endocrine disruption in juvenile roach from English rivers: A preliminary study, Journal of Fish Biology 64 (2) : 580- 586 Download publication

(2004) Routledge, EJ., Coleman, HM., Sumpter, JP. and Eggins, BR., Rapid loss of estrogenicity of steroid estrogens by UVA photolysis and photocatalysis over an immobilised titanium dioxide catalyst, Water Research 38 (14-15) : 3233- 3240

(2003) Halm, S., Kwon, JY., Rand-Weaver, M., Sumpter, JP., Pounds, N., Hutchinson, TH. and Tyler, CR., Cloning and gene expression of P450 17α-hydroxylase, 17,20-lyase cDNA in the gonads and brain of the fathead minnow Pimephales promelas, General and Comparative Endocrinology 130 (3) : 256- 266

(2003) Pickering, AD. and Sumpter, JP., Comprehending endocrine disrupters in aquatic environments, Environmental Science and Technology 37 (17) : 331A- 336A

(2003) Sumpter, JP., Endocrine disruption in wildlife: The future?, Pure and Applied Chemistry 75 (11-12) : 2355- 2360

(2003) Pottinger, TG., Rand-Weaver, N. and Sumpter, JP., Overwinter fasting and re-feeding in rainbow trout: Plasma growth hormone and cortisol levels in relation to energy mobilisation, Comparative Biochemistry and Physiology Part B: Biochemistry and Molecular Biology 136 (3) : 403- 417

(2003) Thorpe, KL., Cummings, RI., Hutchinson, TH., Scholze, M., Brighty, G., Sumpter, JP. and Tyler, CR., Relative potencies and combination effects of steroidal estrogens in fish, Environmental Science and Technology 37 (6) : 1142- 1149

(2003) Pickford, KA., Thomas-Jones, RE., Wheals, B., Tyler, CR. and Sumpter, JP., Route of exposure affects the oestrogenic response of fish to 4-tert-nonylphenol, Aquatic Toxicology 65 (3) : 267- 279

(2003) Eggen, RIL., Bengtsson, BE., Bowmer, CT., Gerritsen, AAM., Gibert, M., Hylland, K., Johnson, AC., Leonards, P., Nakari, T., Norrgren, L., Sumpter, JP., Suter, MJF., Svenson, A. and Pickering, AD., Search for the evidence of endocrine disruption in the aquatic environment: Lessons to be learned from joint biological and chemical monitoring in the European Project COMPREHEND, Pure and Applied Chemistry 75 (11-12) : 2445- 2450 Download publication

(2003) Faller, P., Kobler, B., Peter, A., Sumpter, JP. and Burkhardt-Holm, P., Stress status of gudgeon (Gobio gobio) from rivers in Switzerland with and without input of sewage treatment plant effluent, Environmental Toxicology and Chemistry 22 (9) : 2063- 2072

(2002) Jobling, S., Beresford, N., Nolan, M., Rodgers-Gray, T., Brighty, GC., Sumpter, JP. and Tyler, CR., Altered sexual maturation and gamete production in wild roach (rutilus rutilus) living in rivers that receive treated sewage effluents, Biology of Reproduction 66 (2) : 272- 281

(2002) Kirk, LA., Tyler, CR., Lye, CM. and Sumpter, JP., Changes in estrogenic and androgenic activities at different stages of treatment in wastewater treatment works, Environmental Toxicology and Chemistry 21 (5) : 972- 979

(2002) Sumpter, JP., Endocrine disruption and feminization in fish (Abstract), Toxicology 178 (1) : 39- 40

(2002) Sheahan, DA., Brighty, GC., Daniel, M., Kirby, SJ., Hurst, MR., Kennedy, J., Morris, S., Routledge, EJ., Sumpter, JP. and Waldock, MJ., Estrogenic activity measured in a sewage treatment works treating industrial inputs containing high concentrations of alkylphenolic compounds - a case study, Environmental Toxicology and Chemistry 21 (3) : 507- 514

(2002) Halm, S., Pounds, N., Maddix, S., Rand-Weaver, M., Sumpter, JP., Hutchinson, TH. and Tyler, CR., Exposure to exogenous 17β-oestradiol disrupts P450aromB mRNA expression in the brain and gonad of adult fathead minnows (Pimephales promelas), Aquatic Toxicology 60 (3-4) : 285- 299

(2002) Sheahan, DA., Brighty, GC., Daniel, M., Jobling, S., Harries, JE., Hurst, MR., Kennedy, J., Kirby, SJ., Morris, S., Routledge, EJ., Sumpter, JP. and Waldock, MJ., Reduction in the estrogenic activity of a treated sewage effluent discharge to an English river as a result of a decrease in the concentration of industrially derived surfactants, Environmental Toxicology and Chemistry 21 (3) : 515- 519

(2002) Panter, GH., Hutchinson, TH., Länge, R., Lye, CM., Sumpter, JP., Zerulla, M. and Tyler, CR., Utility of a juvenile fathead minnow screening assay for detecting (anti-)estrogenic substances, Environmental Toxicology and Chemistry 21 (2) : 319- 326

(2002) Jobling, S., Coey, S., Whitmore, JG., Kime, DE., Van Look, KJW., McAllister, BG., Beresford, N., Henshaw, AC., Brighty, G., Tyler, CR. and Sumpter, JP., Wild intersex roach (rutilus rutilus) have reduced fertility, Biology of Reproduction 67 (2) : 515- 524

(2001) Miller, D., Wheals, BB., Beresford, N. and Sumpter, JP., Estrogenic activity of phenolic additives determined by an in vitro yeast bioassay, Environmental Health Perspectives 109 (2) : 133- 138 Download publication

(2001) Nolan, M., Jobling, S., Brighty, G., Sumpter, JP. and Tyler, CR., A histological description of intersexuality in the roach, Journal of Fish Biology 58 (1) : 160- 176

(2001) Thorpe, KL., Hutchinson, TH., Hetheridge, MJ., Scholze, M., Sumpter, JP. and Tyler, CR., Assessing the biological potency of binary mixtures of environmental estrogens using vitellogenin induction in juvenile rainbow trout (oncorhynchus mykiss), Environmental Science and Technology 35 (12) : 2476- 2481

(2001) Elsby, R., Maggs, JL., Ashby, J., Paton, D., Sumpter, JP. and Park, BK., Assessment of the effects of metabolism on the estrogenic activity of xenoestrogens: a two-stage approach coupling human liver microsomes and a yeast estrogenicity assay, Journal of Pharmacology and Experimental Therapeutics 296 (2) : 329- 337

(2001) Halm, S., Rand-Weaver, M., Sumpter, JP. and Tyler, CR., Cloning and molecular characterization of an ovarian-derived (brain-like) P450 aromatase cDNA and development of a competitive RT-PCR assay to quantify its expression in the fathead minnow (pimephales promelas), Fish Physiology and Biochemistry 24 (1) : 49- 62

(2001) Länge, R., Hutchinson, TH., Croudace, CP., Siegmund, F., Schweinfurth, H., Hampe, P., Panter, GH. and Sumpter, JP., Effects of the synthetic estrogen 17α-ethinylestradiol on the life-cycle of the fathead minnow (pimephales promelas), Environmental Toxicology and Chemistry 20 (6) : 1216- 1227

(2001) Rodgers-Gray, TP., Jobling, S., Kelly, C., Morris, S., Brighty, G., Waldock, MJ., Sumpter, JP. and Tyler, CR., Exposure of juvenile roach (rutilus rutilus) to treated sewage effluent induces dose-dependent and persistent disruption in gonadal duct development, Environmental Science and Technology 35 (3) : 462- 470

(2001) Harris, CA., Santos, EM., Janbakhsh, A., Pottinger, TG., Tyler, CR. and Sumpter, JP., Nonylphenol affects gonadotropin levels in the pituitary gland and plasma of female rainbow trout, Environmental Science and Technology 35 (14) : 2909- 2916

(2001) Sohoni, P., Lefevre, PA., Ashby, J. and Sumpter, JP., Possible androgenic/anti-androgenic activity of the insecticide fenitrothion, Journal of Applied Toxicology 21 (3) : 173- 178

(2001) Johnson, AC. and Sumpter, JP., Removal of endocrine-disrupting chemicals in activated sludge treatment works, Environmental Science and Technology 35 (24) : 4697- 4703

(2001) Sohoni, P., Tyler, CR., Hurd, K., Caunter, J., Hetheridge, M., Williams, T., Woods, C., Evans, M., Toy, R., Gargas, M. and Sumpter, JP., Reproductive effects of long-term exposure to bisphenol A in the fathead minnow (pimephales promelas), Environmental Science and Technology 35 (14) : 2917- 2925

(2001) van Aerle, R., Nolan, M., Jobling, S., Christiansen, LB., Sumpter, JP. and Tyler, CR., Sexual disruption in a second species of wild cyprinid fish (the gudgeon, gobio gobio) in United Kingdom freshwaters, Environmental Toxicology and Chemistry 20 (12) : 2841- 2847 Download publication

(2000) Harries, JE., Runnalls, T., Hill, E., Harris, CA., Maddix, S., Sumpter, JP. and Tyler, CR., Development of a reproductive performance test for endocrine disrupting chemicals using pair-breeding fathead minnows (pimephales promelas), Environmental Science and Technology 34 (14) : 3003- 3011

(2000) Thorpe, KL., Hutchinson, TH., Hetheridge, MJ., Sumpter, JP. and Tyler, CR., Development of an in vivo screening assay for estrogenic chemicals using juvenile rainbow trout (oncorhynchus mykiss), Environmental Toxicology and Chemistry 19 (11) : 2812- 2820

(2000) Routledge, EJ., White, R., Parker, MG. and Sumpter, JP., Differential effects of xenoestrogens on coactivator recruitment by estrogen receptor (ER)α and ERβ, Journal of Biological Chemistry 275 (46) : 35986- 35993

(2000) Schmieder, PK., Aptula, AO., Routledge, EJ., Sumpter, JP. and Mekenyan, OG., Estrogenicity of alkylphenolic compounds: a 3-D structure-activity evaluation of gene activation, Environmental Toxicology and Chemistry 19 (7) : 1727- 1740

(2000) Panter, GH., Thompson, RS. and Sumpter, JP., Intermittent exposure of fish to estradiol, Environmental Science and Technology 34 (13) : 2756- 2760

(2000) Beresford, N., Routledge, EJ., Harris, CA. and Sumpter, JP., Issues arising when interpreting results from an in vitro assay for estrogenic activity, Toxicology and Applied Pharmacology 162 (1) : 22- 33 Download publication

(2000) Rodgers-Gray, TP., Jobling, S., Morris, S., Kelly, C., Kirby, S., Janbakhsh, A., Harries, JE., Waldock, MJ., Sumpter, JP. and Tyler, CR., Long-term temporal changes in the estrogenic composition of treated sewage effluent and its biological effects on fish, Environmental Science and Technology 34 (8) : 1521- 1528

(2000) Tyler, CR., Beresford, N., Van der Woning, M., Sumpter, JP. and Thorpe, K., Metabolism and environmental degradation of pyrethroid insecticides produce compounds with endocrine activities, Environmental Toxicology and Chemistry 19 (4) : 801- 809

(2000) Elsby, R., Ashby, J., Sumpter, JP., Brooks, AN., Pennie, WD., Maggs, JL., Lefevre, PA., Odum, J., Beresford, N., Paton, D. and Park, BK., Obstacles to the prediction of estrogenicity from chemical structure: assay-mediated metabolic transformation and the apparent promiscuous nature of the estrogen receptor, Biochemical Pharmacology 60 (10) : 1519- 1530

(2000) Ashby, J., Odum, J., Paton, D., Lefevre, PA., Beresford, N. and Sumpter, JP., Re-evaluation of the first synthetic estrogen, 1-keto-1,2,3,4-tetrahydrophenanthrene, and bisphenol A, using both the ovariectomised rat model used in 1933 and additional assays, Toxicology Letters 115 (3) : 231- 238 Download publication

(1999) Andersen, HR., Andersson, AM., Arnold, SF., Autrup, H., Barfoed, M., Beresford, NA., Bjerregaard, P., Christiansen, LB., Gissel, B., Hummel, R., Jørgensen, EB., Korsgaard, B., Le, GR., Leffers, H., McLachlan, J., Møller, A., Nielsen, JB., Olea, N., Oles-Karasko, A., Pakdel, F., Pedersen, KL., Perez, P., Skakkebœk, NE., Sonnenschein, C., Soto, AM., Sumpter, JP., Thorpe, SM. and Grandjean, P., Comparison of short-term estrogenicity tests for identification of hormone-disrupting chemicals, Environmental Health Perspectives Supplements 107 (S1) : 89- 108 Download publication

(1999) Harries, JE., Janbakhsh, A., Jobling, S., Matthiessen, P., Sumpter, JP. and Tyler, CR., Estrogenic potency of effluent from two sewage treatment works in the United Kingdom, Environmental Toxicology and Chemistry 18 (5) : 932- 937 Download publication

(1999) Carnevali, O., Centonze, F., Brooks, S., Marota, I. and Sumpter, JP., Molecular cloning and expression of ovarian cathepsin D in seabream, sparus aurata, Biology of Reproduction 61 (3) : 785- 791

(1999) Ashby, J., Tinwell, H., Pennie, W., Brooks, AN., Lefevre, PA., Beresford, N. and Sumpter, JP., Partial and weak oestrogenicity of the red wine constituent resveratrol: consideration of its superagonist activity in MCF-7 cells and its suggested cardiovascular protective effects, Journal of Applied Toxicology 19 (1) : 39- 45

(1999) Routledge, EJ., Waldock, M. and Sumpter, JP., Response to comment on "Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening", Environmental Science and Technology 33 (2) : 371-

(1999) Baker, VA., Hepburn, PA., Kennedy, SJ., Jones, PA., Lea, LJ., Sumpter, JP. and Ashby, J., Safety evaluation of phytosterol esters. Part 1. Assessment of oestrogenicity using a combination of in vivo and in vitro assays, Food and Chemical Toxicology 37 (1) : 13- 22

(1999) Panter, GH., Thompson, RS., Beresford, N. and Sumpter, JP., Transformation of a non-oestrogenic steroid metabolite to an oestrogenically active substance by minimal bacterial activity, Chemosphere 38 (15) : 3579- 3596

(1998) Sharpe, RM., Turner, KJ. and Sumpter, JP., Endocrine disruptors and testis development, Environmental Health Perspectives 106 (5) : A220- A221

(1998) Panter, GH., Thompson, RS. and Sumpter, JP., Adverse reproductive effects in male fathead minnows (pimephales promelas) exposed to environmentally relevant concentrations of the natural oestrogens, oestradiol and oestrone, Aquatic Toxicology 42 (4) : 243- 253

(1998) Gimeno, S., Komen, H., Jobling, S., Sumpter, J. and Bowmer, T., Demasculinisation of sexually mature male common carp, Cyprinus carpio, exposed to 4-tert-pentylphenol during spermatogenesis, Aquatic Toxicology 43 (2-3) : 93- 109

(1998) Tyler, CR., Jobling, S. and Sumpter, JP., Endocrine disruption in wildlife: A critical review of the evidence, Critical Reviews in Toxicology 28 (4) : 319- 361

(1998) Ashfield, LA., Pottinger, TG. and Sumpter, JP., Exposure of female juvenile rainbow trout to alkylphenolic compounds results in modifications to growth and ovosomatic index, Environmental Toxicology and Chemistry 17 (4) : 679- 686

(1998) Desbrow, C., Routledge, EJ., Brighty, GC., Sumpter, JP. and Waldock, M., Identification of estrogenic chemicals in STW effluent. 1. Chemical fractionation and in vitro biological screening, Environmental Science and Technology 32 (11) : 1549- 1558

(1998) Routledge, EJ., Sheahan, D., Desbrow, C., Brighty, GC., Waldock, M. and Sumpter, JP., Identification of estrogenic chemicals in STW effluent. 2. In vivo responses in trout and roach, Environmental Science and Technology 32 (11) : 1559- 1565

(1998) Bennetau-Pelissero, C., Flouriot, G., Valotaire, Y., Sumpter, JP. and Le Menn, F., Induction of rainbow trout estradiol receptor mRNA and vitellogenin mRNA by phytoestrogens in hepatocyte cultures, Annals of the New York Academy of Sciences 839 600- 601

(1998) Prat, F., Coward, K., Sumpter, JP. and Tyler, CR., Molecular characterization and expression of two ovarian lipoprotein receptors in the rainbow trout, oncorhynchus mykiss, Biology of Reproduction 58 (5) : 1146- 1153

(1998) Sumpter, JP., Reproductive effects from oestrogen activity in polluted water, Archives of Toxicology 20 143- 150

(1998) Sohoni, P. and Sumpter, JP., Several environmental oestrogens are also anti-androgens, Journal of Endocrinology 158 (3) : 327- 339

(1998) Routledge, EJ., Parker, J., Odum, J., Ashby, J. and Sumpter, JP., Some alkyl hydroxy benzoate preservatives (parabens) are estrogenic, Toxicology and Applied Pharmacology 153 (1) : 12- 19

(1998) Jobling, S., Nolan, M., Tyler, CR., Brighty, G. and Sumpter, JP., Widespread sexual disruption in wild fish, Environmental Science and Technology 32 (17) : 2498- 2506

(1998) Sumpter, JP., Xenoendorine disrupters - environmental impacts, Toxicology Letters 102-103 337- 342

(1997) Brooks, S., Tyler, CR. and Sumpter, JP., Quality in fish: what makes a good egg?, Reviews in Fish Biology and Fisheries 7 (4) : 387- 416

(1997) Ashby, J., Lefevre, PA., Odum, J., Tinwell, H., Kennedy, SJ., Beresford, N. and Sumpter, JP., Failure to confirm estrogenic activity for benzoic acid and clofibrate: Implications for lists of endocrine-disrupting agents, Regulatory Toxicology and Pharmacology 26 (1) : 96- 101

(1997) Harris, CA., Henttu, P., Parker, MG. and Sumpter, JP., The estrogenic activity of phthalate esters in vitro, Environmental Health Perspectives 105 (8) : 802- 811

(1997) Odum, J., Lefevre, PA., Tittensor, S., Paton, D., Routledge, EJ., Beresford, NA., Sumpter, JP. and Ashby, J., The rodent uterotrophic assay: Critical protocol features, studies with nonyl phenols, and comparison with a yeast estrogenicity assay, Regulatory Toxicology and Pharmacology 25 (2) : 176- 188 Download publication

(1997) Harries, JE., Sheahan, DA., Jobling, S., Matthiessen, P., Neall, M., Sumpter, JP., Taylor, T. and Zaman, N., Estrogenic activity in five United Kingdom rivers detected by measurement of vitellogenesis in caged male trout, Environmental Toxicology and Chemistry 16 (3) : 534- 542 Download publication

(1997) Routledge, EJ. and Sumpter, JP., Structural features of alkylphenolic chemicals associated with estrogenic activity, Journal of Biological Chemistry 272 (6) : 3280- 3288 Download publication

(1997) Sumpter, JP., Environmental control of fish reproduction: A different perspective, Fish Physiology and Biochemistry 17 (1-6) : 25- 31

(1997) Knudsen, FR., Schou, AE., Wiborg, ML., Mona, E., Tollefsen, K-E., Stenersen, J. and Sumpter, JP., Increase of plasma vitellogenin concentration in rainbow trout (Oncorhynchus mykiss) exposed to effluents from oil refinery treatment works and municipal sewage, Bulletin of Environmental Contamination and Toxicology 59 (5) : 802- 806

(1997) Penlington, MC., Williams, MA., Sumpter, JP., Rand-Weaver, M., Hoole, D. and Arme, C., Isolation and characterisation of mRNA encoding the salmon- and chicken- II type gonadotrophin-releasing hormones in the teleost fish Rutilus rutilus (Cyprinidae), Journal of Molecular Endocrinology 19 (3) : 337- 346

(1997) Brooks, S., Tyler, CR., Carnevali, O., Coward, K. and Sumpter, JP., Molecular characterisation of ovarian cathepsin D in the rainbow trout, Oncorhynchus mykiss, Gene 201 (1-2) : 45- 54

(1997) Bon, E., Barbe, U., Nuñez Rodriguez, J., Cuisset, B., Pelissero, C., Sumpter, JP. and Le Menn, F., Plasma vitellogenin levels during the annual reproductive cycle of the female rainbow trout (Oncorhynchus mykiss): Establishment and validation of an ELISA, Comparative Biochemistry and Physiology - B Biochemistry and Molecular Biology 117 (1) : 75- 84

(1997) Ashby, J., Lefevre, PA., Odum, J., Harris, CA., Routledge, EJ. and Sumpter, JP., Synergy between synthetic oestrogens?, Nature 385 (6616) : 494- 494

(1996) Harries, JE., Sheahan, DA., Jobling, S., Matthiessen, P., Neall, P., Routledge, EJ., Rycroft, R., Sumpter, JP. and Tylor, T., A survey of estrogenic activity in United Kingdom inland waters, Environmental Toxicology & Chemistry 15 (11) : 1993- 2002

(1996) Tyler, CR., van der Eerden, B., Jobling, S., Panter, G. and Sumpter, JP., Measurement of vitellogenin, a biomarker for exposure to oestrogenic chemicals, in a wide variety of cyprinid fish, Journal of Comparative Physiology B 166 (7) : 418- 426

(1996) Toppari, J., Larsen, JC., Christiansen, P., Giwercman, A., Grandjean, P., Guillette, LJ., Jegou, B., Jensen, TK., Jouannet, P., Keiding, N., Leffers, H., McLachlan, JA., Meyer, O., Muller, J., RajpertDeMeyts, E., Scheike, T., Sharpe, R., Sumpter, J. and Skakkebaek, NE., Male reproductive health and environmental xenoestrogens, Environmental Health Perspectives 104 (S4) : 741- 803

(1996) Jobling, S., Sheahan, D., Osborne, JA., Matthiessen, P. and Sumpter, JP., Inhibition of testicular growth in rainbow trout (Oncorhynchus mykiss) exposed to estrogenic alkylphenolic chemicals, Environmental Toxicology and Chemistry 15 (2) : 194- 202 Download publication

(1996) Pelissero, C., Lenczowski, MJP., Chinzi, D., Davail-Cuisset, B., Sumpter, JP. and Fostier, A., Effects of flavonoids on aromatase activity, an in vitro study, Journal of Steroid Biochemistry and Molecular Biology 57 (3-4) : 215- 223

(1996) Routledge, EJ. and Sumpter, JP., Estrogenic activity of surfactants and some of their degradation products assessed using a recombinant yeast screen, Environmental Toxicology and Chemistry 15 (3) : 241- 248

(1996) Paul, M., Sumpter, JP. and Lindsay, KS., Factors affecting pentoxifylline stimulation of sperm kinematics in suspensions, Human Reproduction 11 (9) : 1929- 1935

(1996) Nagler, JJ., Scott, AP., Tyler, CR. and Sumpter, JP., Gonadotropins I and II do not stimulate the in vitro secretion of 17α,20β-dihydroxy-4-pregnen-3-one 20-sulphate by rainbow trout gonads during final sexual maturation, Fish Physiology and Biochemistry 15 (2) : 149- 156

(1996) Tyler, CR., Pottinger, TG., Santos, E., Sumpter, JP., Price, SA., Brooks, S. and Nagler, JJ., Mechanisms controlling egg size and number in the rainbow trout, oncorhynchus mykiss, Biology of Reproduction 54 (1) : 8- 15

(1996) Tyler, CR. and Sumpter, JP., Oocyte growth and development in teleosts, Reviews in Fish Biology and Fisheries 6 (3) : 287- 318

(1996) Paul, M., Sumpter, JP. and Lindsay, KS., The paradoxical effects of pentoxifylline on the binding of spermatozoa to the human zona pellucida, Human Reproduction 11 (4) : 814- 819

(1996) Prat, F., Sumpter, JP. and Tyler, CR., Validation of radioimmunoassays for two salmon gonadotropins (GTH I and GTH II) and their plasma concentrations throughout the reproductive cycle in male and female rainbow trout (oncorhynchus mykiss), Biology of Reproduction 54 (6) : 1375- 1382

(1995) Sharpe, RM., Fisher, JS., Millar, MM., Jobling, S. and Sumpter, JP., Gestational and lactational exposure of rats to xenoestrogens results in reduced testicular size and sperm production, Environmental Health Perspectives 103 (12) : 1136- 1143

(1995) Sumpter, JP. and Jobling, S., Vitellogenesis as a biomarker for estrogenic contamination of the aquatic environment, Environmental Health Perspectives 103 (Supplement 7) : 173- 178 Download publication

(1995) Bicknell, RJ., Herbison, AE. and Sumpter, JP., Estrogenic activity of an environmentally persistent alkylphenol in the reproductive-tract but not the brain of rodents, The Journal of Steroid Biochemistry and Molecular Biology 54 (1-2) : 7- 9

(1995) Rand-Weaver, M., Pottinger, TG. and Sumpter, JP., Pronounced seasonal rhythms in plasma somatolactin levels in rainbow trout, Journal of Endocrinology 146 (1) : 113- 119

(1995) Jobling, S., Reynolds, T., White, R., Parker, MG. and Sumpter, JP., A variety of environmentally persistent chemicals, including some phthalate plasticizers, are weakly estrogenic, Environmental Health Perspectives 103 (6) : 582- 587 Download publication

(1995) Paul, M., Sumpter, JP. and Lindsay, KS., Action of pentoxifylline directly on semen, Human Reproduction 10 (2) : 354- 359

(1995) Sumpter, JP., Feminized responses in fish to environmental estrogens, Toxicology Letters 82-83 737- 742

(1995) Rand-Weaver, M., Pottinger, TG., Guest, A., Martin, P., Smal, J. and Sumpter, JP., Somatolactin and growth hormone are differentially correlated to various metabolic parameters in trout, Netherlands Journal of Zoology 45 (1-2) : 129- 131

(1994) White, R., Jobling, S., Hoare, SA., Sumpter, JP. and Parker, MG., Environmentally persistent alkylphenolic compounds are estrogenic, Endocrinology 135 (1) : 175- 182

(1994) Campbell, PM., Pottinger, TG. and Sumpter, JP., Changes in the affinity of estrogen and androgen receptors accompany changes in receptor abundance in brown and rainbow trout, General and Comparative Endocrinology 94 (3) : 329- 340

(1994) Purdom, CE., Hardiman, PA., Bye, VJ., Eno, NC., Tyler, CR. and Sumpter, JP., Estrogenic effects of effluents from sewage treatment works, Chemistry and Ecology 8 (4) : 275- 285

(1994) Nagler, JJ., Tyler, CR. and Sumpter, JP., Ovarian follicles of rainbow trout (Oncorhynchus mykiss) cultured within lamellae survive well, and sequester and process vitellogenin, Journal of Experimental Zoology 269 (1) : 45- 52

(1994) Campbell, PM., Pottinger, TG. and Sumpter, JP., Preliminary evidence that chronic confinement stress reduces the quality of gametes produced by brown and rainbow trout, Aquaculture 120 (1-2) : 151- 169

(1993) Jobling, S. and Sumpter, JP., Detergent components in sewage effluent are weakly oestrogenic to fish: An in vitro study using rainbow trout (Oncorhynchus mykiss) hepatocytes, Aquatic Toxicology 27 (3-4) : 361- 372

(1993) Rand-Weaver, M., Pottinger, TG. and Sumpter, JP., Plasma somatolactin concentrations in salmonid fish are elevated by stress, Journal of Endocrinology 138 (3) : 509- 515

(1993) Sumpter, JP. and Jobling, S., Male sexual development in a sea of estrogen, Lancet 342 (8863) : 124- 125

(1993) Pelissero, C., Flouriot, G., Foucher, JL., Bennetau, B., Dunoguès, J., Le Gac, F. and Sumpter, JP., Vitellogenin synthesis in cultured hepatocytes; an in vitro test for the estrogenic potency of chemicals, The Journal of Steroid Biochemistry and Molecular Biology 44 (3) : 263- 272

(1992) Sumpter, JP., Control of growth of rainbow trout (Oncorhynchus mykiss), Aquaculture 100 (1-3) : 299- 320

(1992) Pelissero, C. and Sumpter, JP., Steroids and "steroid-like" substances in fish diets, Aquaculture 107 (4) : 283- 301

(1992) Campbell, PM., Pottinger, TG. and Sumpter, JP., Stress reduces the quality of gametes produced by rainbow trout, Biology of Reproduction 47 (6) : 1140- 1150

(1991) Lebail, PY., Sumpter, JP., Carragher, JF., Mourot, B., Niu, PD. and Weil, C., Development and validation of a highly sensitive radioimmunoassay for chinook salmon (Oncorhynchus-Tshawtscha) growth-hormone, General and Comparative Endocrinology 83 (1) : 75- 85

(1991) Pickering, AD., Pottinger, TG., Sumpter, JP., Carragher, JF. and Lebail, PY., Effects of acute and chronic stress on the levels of circulating growth-hormone in the rainbow trout, Oncorhynchus-Mykiss, General and Comparative Endocrinology 83 (1) : 86- 93

(1991) Tyler, CR., Sumpter, JP. and Campbell, PM., Uptake of vitellogenin into oocytes during early vitellogenic development in the rainbow-trout, Oncorhynchus-mykiss (Walbaum), Journal of Fish Biology 38 (5) : 681- 689

(1991) Tyler, CR., Sumpter, JP., Kawauchi, H. and Swanson, P., Involvement of gonadotropin in the uptake of vitellogenin into vitellogenic oocytes of the rainbow trout, Oncorhynchus mykiss, General and Comparative Endocrinology 84 (2) : 291- 299

(1991) Sumpter, JP., Lincoln, RF., Bye, VJ., Carragher, JF. and Le Bail, PY., Plasma growth hormone levels during sexual maturation in diploid and triploid rainbow trout (Oncorhynchus mykiss), General and Comparative Endocrinology 83 (1) : 103- 110

(1991) Sumpter, JP., Le Bail, PY., Pickering, AD., Pottinger, TG. and Carragher, JF., The effect of starvation on growth and plasma growth hormone concentrations of rainbow trout, Oncorhynchus mykiss, General and Comparative Endocrinology 83 (1) : 94- 102

(1991) Carragher, JF. and Sumpter, JP., The mobilization of calcium from calcified tissues of rainbow-trout (Oncorhynchus-Mykiss) induced to synthesize vitellogenin, Comparative Biochemistry and Physiology: Part A 99 (1-2) : 169- 172

(1990) Tyler, CR., Sumpter, JP. and Bromage, NR., An in vitro culture system for studying vitellogenin uptake into ovarian follicles of the rainbow trout, Salmo gairdneri, Journal of Experimental Zoology 255 (2) : 216- 231

(1990) Carragher, JF. and Sumpter, JP., Corticosteroid physiology in fish, Progress in clinical and biological research 342 487- 492

(1990) Tyler, CR. and Sumpter, JP., The development of a radioimmunoassay for carp, Cyprinus carpio, vitellogenin, Fish Physiology and Biochemistry 8 (2) : 129- 140

(1990) Tyler, CR., Sumpter, JP. and Witthames, PR., The dynamics of oocyte growth during vitellogenesis in the rainbow trout (oncorhynchus mykiss), Biology of Reproduction 43 (2) : 202- 209

(1990) Tyler, CR., Sumpter, JP. and Handford, RM., The dynamics of vitellogenin sequestration into vitellogenic ovarian follicles of the rainbow trout, Salmo gairdneri, Fish Physiology and Biochemistry 8 (3) : 211- 219

(1990) Carragher, JF. and Sumpter, JP., The effect of cortisol on the secretion of sex steroids from cultured ovarian follicles of rainbow trout, General and Comparative Endocrinology 77 (3) : 403- 407

(1990) Tyler, CR. and Sumpter, JP., The purification and partial characterization of carp, Cyprinus carpio, vitellogenin, Fish Physiology and Biochemistry 8 (2) : 111- 120

(1989) Sumpter, JP. and Scott, AP., Seasonal variations in plasma and pituitary levels of gonadotrophin in males and females of two strains of rainbow trout (Salmo gairdneri), General and Comparative Endocrinology 75 (3) : 376- 388

(1989) Scott, AP. and Sumpter, JP., Seasonal variations in testicular germ cell stages and in plasma concentrations of sex steroids in male rainbow trout (Salmo gairdneri) maturing at 2 years old, General and Comparative Endocrinology 73 (1) : 46- 58

(1989) Carragher, JF., Sumpter, JP., Pottinger, TG. and Pickering, AD., The deleterious effects of cortisol implantation on reproductive function in two species of trout, Salmo trutta L. and Salmo gairdneri Richardson, General and Comparative Endocrinology 76 (2) : 310- 321

(1988) Tyler, CR., Sumpter, JP. and Bromage, NR., Selectivity of protein sequestration by vitellogenic oocytes of the rainbow-trout, Salmo-Gairdneri, Journal of Experimental Zoology 248 (2) : 199- 206

(1988) Tyler, CR., Sumpter, JP. and Bromage, NR., Invivo ovarian uptake and processing of vitellogenin in the rainbow-trout, Salmo-Gairdneri, Journal of Experimental Zoology 246 (2) : 171- 179

(1987) Pickering, AD., Pottinger, TG., Carragher, J. and Sumpter, JP., The effects of acute and chronic stress on the levels of reproductive hormones in the plasma of mature male brown trout, Salmo-Trutta-L, General and Comparative Endocrinology 68 (2) : 249- 259

(1987) Carragher, J. and Sumpter, J., The effect of thermal stress on blood hormone levels of rainbow-trout, General and Comparative Endocrinology 66 (1) : 15- 15

(1987) Tyler, C., Sumpter, J. and Bromage, N., Vitellogenin uptake by cultured oocytes of rainbow-trout (Salmo-gairdneri), General and Comparative Endocrinology 66 (1) : 19- 20

(1987) Pickering, AD., Pottinger, TG. and Sumpter, JP., On the use of dexamethasone to block the pituitary-interrenal axis in the brown trout, Salmo-Trutta-L, General and Comparative Endocrinology 65 (3) : 346- 353

(1987) Tyler, C., Sumpter, J. and Bromage, N., The specificity of vitellogenin uptake into ovarian follicles of rainbow-trout, Salmo-Gairdneri, Journal of Endocrinology 112 50- 50

(1986) Pickering, AD., Pottinger, TG. and Sumpter, JP., Independence of the pituitary interrenal axis and melanotroph activity in the brown trout, Salmo-Trutta-L under conditions of environmental stress, General and Comparative Endocrinology 64 (2) : 206- 211

(1986) Dye, HM., Sumpter, JP., Fagerlund, UHM. and Donaldson, EM., Changes in reproductive parameters during the spawning migration of pink salmon, Oncorhynchus-Gorbuscha (Walbaum), Journal of Fish Biology 29 (2) : 167- 176

(1986) Sumpter, JP., ACTH-related material in the pituitary gland of the chinook salmon (Oncorhynchus tschawytscha), General and Comparative Endocrinology 62 (3) : 359- 366

(1986) Sumpter, JP. and Donaldson, EM., The development and validation of a radioimmunoassay to measure plasma ACTH levels in salmonid fishes, General and Comparative Endocrinology 62 (3) : 367- 376

(1986) Sumpter, JP., Dye, HM. and Benfey, TJ., The effects of stress on plasma ACTH, α-MSH, and cortisol levels in salmonid fishes, General and Comparative Endocrinology 62 (3) : 377- 385

(1986) Copeland, PA., Sumpter, JP., Walker, TK. and Croft, M., Vitellogenin levels in male and female rainbow trout (Salmo gairdneri richardson) at various stages of the reproductive cycle, Comparative Biochemistry and Physiology -- Part B: Biochemistry and 83 (2) : 487- 493

(1985) Sumpter, JP., Pickering, AD. and Pottinger, TG., Stress-induced elevation of plasma α-MSH and endorphin in brown trout, Salmo trutta L., General and Comparative Endocrinology 59 (2) : 257- 265

(1984) Sumpter, JP., Scott, AP., Baynes, SM. and Witthames, PR., Early stages of the reproductive cycle in virgin female rainbow trout (Salmo gairdneri Richardson), Aquaculture 43 (1-3) : 235- 242

(1984) Rodrigues, KT. and Sumpter, JP., Effects of background adaptation on the pituitary and plasma concentrations of some pro-opiomelanocortin-related peptides in the rainbow trout (Salmo gairdneri), Journal of Endocrinology 101 (3) : 277- 284

(1984) Burke, MG., Leatherland, JF. and Sumpter, JP., Seasonal changes in serum testosterone, 11-ketotestosterone, and 1713-estradiol levels in the brown bullhead, Ictalurus nebuIosus Lesueur, Canadian Journal of Zoology 62 (6) : 1195- 1199 Download publication

(1984) Copeland, PA., Sumpter, JP. and Scott, AP., The biological actions of purified salmon gonadotropin, General and Comparative Endocrinology 53 (3) : 433- 434

(1984) Sumpter, JP. and Denningkendall, PA., The control of dogfish (Scyliorhinus-canicula) color-change by melanotrophins, General and Comparative Endocrinology 53 (3) : 469- 469

(1984) Sumpter, JP., Denning-Kendall, PA. and Lowry, PJ., The involvement of melanotrophins in physiological colour changes in the dogfish Scyliorhinus canicula, General and Comparative Endocrinology 56 (3) : 360- 367

(1984) Rodrigues, KT. and Sumpter, JP., The involvement of peptides derived from proopiomelanocortin (POMC) in the control of color-change in the rainbow-trout, Salmo-Gairdneri, General and Comparative Endocrinology 53 (3) : 468- 469

(1984) Rodrigues, KT. and Sumpter, JP., The radioimmunoassay of α-melanocyte-stimulating hormone and endorphin in trout (Salmo gairdneri) and the effect of blinding on the plasma levels of these peptides, General and Comparative Endocrinology 54 (1) : 69- 75

(1984) Burke, M., Leatherland, JF. and Sumpter, JP., Thyroid-hormone involvement in gonadal maturation of the brown bullhead, Ictalurus-nebulosus, General and Comparative Endocrinology 53 (3) : 451- 451

(1983) Scott, AP. and Sumpter, JP., A comparison of the female reproductive cycles of autumn-spawning and winter-spawning strains of rainbow trout (Salmo gairdneri Richardson), General and Comparative Endocrinology 52 (1) : 79- 85

(1983) Rodrigues, KT., Jenks, BG. and Sumpter, JP., Biosynthesis of pro-opiomelanocortin-related peptides in the neurointermediate lobe of the pituitary gland of the rainbow trout (Salmo gairdneri), Journal of Endocrinology 98 (2) : 271- 282

(1983) Scott, AP., Sumpter, JP. and Hardiman, PA., Hormone changes during ovulation in the rainbow trout (Salmo-Gairdneri Richardson), General and Comparative Endocrinology 49 (1) : 128- 134

(1983) Rodrigues, K. and Sumpter, JP., The distribution of some proopiomelanocortin-related peptides in the pituitary gland of the rainbow trout, Salmo gairdneri, General and Comparative Endocrinology 51 (3) : 454- 459

(1982) Arme, C., Griffiths, DV. and Sumpter, JP., Evidence against the hypothesis that the plerocercoid larva of Ligula-intestinalis (Cestoda, Pseudophyllidea) produces a sex steroid that interferes with host reproduction, Journal of Parasitology 68 (1) : 169- 171

(1982) Dodd, JM., Dodd, MHI., Sumpter, JP. and Jenkins, N., Gonadotrophic activity in the buccal lobe (Rachendachhypophyse) of the pituitary gland of the rabbit fish Hydrolagus colliei (Chondrichthyes: Holocephali), General and Comparative Endocrinology 48 (2) : 174- 180

(1982) Leatherland, JF., Copeland, P., Sumpter, JP. and Sonstegard, RA., Hormonal-control of gonadal maturation and development of secondary sexual characteristics in coho salmon, Oncorhynchus-Kisutch, from lakes Ontario, Erie and Michigan, General and Comparative Endocrinology 48 (2) : 196- 204

(1982) Denningkendall, PA., Sumpter, JP. and Lowry, PJ., Peptides derived from pro-opiocortin in the pituitary-gland of the dogfish, Squalus-Acanthias, Journal of Endocrinology 93 (3) : 381- 390

(1982) Denningkendall, PA., Sumpter, JP. and Lowry, PJ., Proopiocortin and peptides derived from it in the pituitary-gland of the dogfish, Squalus-Acanthias, General and Comparative Endocrinology 46 (3) : 362- 362

(1981) Stuart-Kregor, PAC., Sumpter, JP. and Dodd, JM., The involvement of gonadotrophin and sex steroids in the control of reproduction in the parr and adults of Atlantic salmon, Salmo salar L, Journal of Fish Biology 18 (1) : 59- 72

(1981) Sumpter, JP. and Wood, CRC., The trout, Biologist 28 (4) : 219- 224

(1980) Sumpter, JP., Jenkins, N., Duggan, RT. and Dodd, JM., The steroidogenic effects of pituitary extracts from a range of elasmobranch species on isolated testicular cells of quail, and their neutralisation by a dogfish anti-gonadotrophin, General and Comparative Endocrinology 40 (3) : 331- 331

(1978) Sumpter, JP., Jenkins, N. and Dodd, JM., Gonadotrophic hormone in the pituitary gland of the dogfish (Scyliorhinus canicula L.): Distribtuion and physiological significance, General and Comparative Endocrinology 36 (2) : 275- 285

(1978) Sumpter, JP., Jenkins, N. and Dodd, JM., Hormonal control of steroidogenesis in an elasmobranch fish (Scyliorhinus canicula L.): Studies using a specific anti-gonadotrophic antibody, Journal of Endocrinology 79 (2) : 28- 29

(1978) Sumpter, JP., Follett, BK., Jenkins, N. and Dodd, JM., Studies on the purification and properties of gonadotrophin from ventral lobes of the pituitary gland of the dogfish (Scyliorhinus canicula L.), General and Comparative Endocrinology 36 (2) : 264- 274

(1978) Sumpter, JP., Follett, BK. and Dodd, JM., Studies on the purification of gonadotrophin from dogfish (Scyliorhinus canicula L.) pituitary glands, Annales de Biologie Animale, Biochimie, Biophysique 18 (4) : 787- 791

(1978) Jenkins, N., Sumpter, JP. and Follett, BK., The effects of vertebrate gonadotrophins on androgen release in vitro from testicular cells of Japanese quail and a comparison with their radioimmunoassay activities, General and Comparative Endocrinology 35 (3) : 309- 321

Conference Papers

(2008) Harris, CA., Runnalls, TJ., Hamilton, PB., Jobling, S., Tyler, CR. and Sumpter, JP., Assessing the reproductive ability of intersex roach, 18th Annual Meeting of SETAC Europe

(2008) Harris, CA., Runnalls, TJ., Hamilton, PB., Jobling, S., Tyler, CR. and Sumpter, JP., Assessing the reproductivity ability of intersex roach (Poster), 5th Annual Meeting of the SETAC World Congress

(2008) Paulos, P., Runnalls, T., Hala, D., Nallani, G., Venebles, B., La Point, T., Sumpter, J. and Huggett, D., Effects of norethindrone, a synthetic progestin, on reproductive parameters in fish, 29th Annual Meeting of SETAC North America

(1994) Sumnpter, JP., Pottinger, TG., Rand-Weaver, M. and Campbell, PM., The wide-ranging effects of stress on fish, , Perspectives in Comparative Endocrinology 535- 538

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