PhD topics for research students

Find below a list of currently available self-funded PhD topics.

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We encourage all students to contact the supervisor or the alternative contact person for more information and an informal chat to discuss the process of applying and preparing your research statement. For more information on how to apply click here.

Description
Supervisor
Funding
AI-Driven Multimodal Biomedical Data Fusion
Technological advances in biomedicine now enable the collection of high-dimensional, heterogeneous data across multiple platforms, including imaging, genomics, transcriptomics, metabolomics and clinic...
Yongmin Li
Doreen Lau
Self Funded
How do individual histone modifications help cells make decisions?
We are looking for a highly motivated, independent-thinking candidate to undertake a PhD project exploring the role of individual histone modifications in nuclear organisation, regulation of transcrip...
Self Funded
Elucidating the mechanisms of early-stage breast cancer initiation
Using both transgenic cell lines and transgenic mouse models available in our research group, this project will determine the causal effects of increased accumulation of Reactive Oxygen Species (ROS) ...
Ahmet Ucar
Self Funded
Individual histone modification roles in regulation of transcription and cell decision-making
We are looking for a highly motivated, technically able and independent-thinking candidate to undertake a PhD project exploring the role of individual histone modifications in nuclear organisation, re...
Self Funded
The effect on genome behaviour of growing cells in 3D matrices
There has been a small amount of evidence in the literature that growing cells in 3D scaffolds instead of 2D monolayers alters genome behaviour and organisation such that nuclear structure is altered ...
Self Funded
Developing RAC1B-targeting therapies to improve the treatment outcomes for breast cancer
In this project, transgenic reporter cell lines, which will be generated using CRISPR-mediated gene editing, will be used to screen large drug libraries along with functional assays to analyse breast ...
Ahmet Ucar
Self Funded
Hypoxia-driven macrophage modulation in cancer and its impact on T cell immunotherapy
Hypoxia is a common feature of solid tumours. It presents a significant challenge to effective cancer treatment using immunotherapy. Macrophages are known to be recruited to hypoxic regions of the tum...
Doreen Lau
Self Funded
Development of a novel PCR-based assay to evaluate CAR-T safety using a human-based genotoxicity model
The project on offer is to develop a model for the evaluation of safety when using immunotherapy. CAR-T therapy is currently a novel approach to treat cancer using T cells infected by lentivirus vecto...
Michael Themis
Self Funded
3D printing of scaffolds for tissue engineering and regenerative medicine
This project aims to develop multifunctional novel bioactive tissue scaffolds using 3D printing, biomaterials science and controlled drug delivery systems to enhance tissue regeneration. Tissue scaffo...
Self Funded
The role of PE/PPE proteins in tuberculosis
Tuberculosis remains one of the world’s biggest killers due to an infectious disease. There remains an urgent need for the development of effective vaccines and novel drug targets against the disease....
Anthony Tsolaki
Self Funded