Sara was educated at the University of Tehran, where she was awarded a Bachelor degree in animal sciences with first class honours in 2008. She moved to the Biosciences Division at Brunel University London to undertake her MSc in Molecular Medicine and Cancer Research. In 2011, Sara was awarded a scholarship by the School of Health Sciences and Social Care, Brunel University London to investigate Friedreich’s ataxia (FRDA) disease mechanisms using FRDA mouse models and cells under the supervision of Dr Mark Pook. She finished her PhD in 2013 and was awarded Vice Chancellor's best doctoral research prize. She continued her work as a Postdoctoral Research Fellow at Brunel University London to study the efficacy and tolerability of histone methyltransferase (HMTase) inhibitors in FRDA. Sara then joined the Institute of Cancer Research (ICR) as a Postdoctoral Research Fellow in 2015 to study the signaling and metabolic networks in breast cancer. In 2018, she was awarded a research grant from Friedreich’s Ataxia Research Alliance (FARA) and joined Brunel University London as a Principal Investigator to investigate the metabolic signatures of FRDA. Subsequently, she was appointed as a lecturer in Biosciences. Her research continues to investigate FRDA disease pathogenesis and therapy and identify the most effective therapy for FRDA.
- BSc: Animal Sciences, University of Tehran
- MSc: Molecular Medicine & Cancer Research, Brunel University London
- PhD: Biomedical Sciences, Brunel University London
- Postgraduate Certificate in Academic Practice (PgCAP)
- BB5705 – Disease Mechanisms and Therapeutics
- BB5708 – Gene Expression & Epigenetics
- BB3707 – Cellular Pathologies
- BB2712 – Principles of Human Disease
- BB1701 – Principles of Anatomy and Physiology
- BB1703 – Research Skills
Newest selected publications
Sherzai, M., Valle, A., Perry, N., Kalef-Ezra, E., Al-Mahdawi, S., Pook, M. and (2020) 'HMTase Inhibitors as a Potential Epigenetic-based Therapeutic Approach for Friedreich’s Ataxia'. Frontiers in Genetics. ISSN: 1664-8021 Open Access Linket al.
Anjomani-Virmouni, S., Kalef-Ezra, E., Valle, A., Perry, N., Tripp, A., Agliano, A., (2019) 'Elucidation of the metabolic signature of Friedreich’s ataxia'.IARC International Ataxia Research Conference. Washington.Open Access Linket al.
Kalef-Ezra, E., Valle, A., Kleine, P., Oggianu, C., Hannana, T., Al-Mahdawi, S., (2019) 'Genotype and Phenotype Characterisation of an Enhanced Friedreich Ataxia GAA Repeat Expansion Mouse Model Fxn_null::YG8s(GAA)>800'.IARC International Ataxia Research Conference. Washington, USA.Open Access Linket al.
Koundouros, N., Tripp, A., Karali, E., Valle, A., Inglese, P., Anjomani-Virmouni, S., (2019) 'Near Real-time Stratification of PIK3CA Mutant Breast Cancers Using the iKnife'.211th Meeting of the Pathological Society of Great Britain and Ireland. London, UK. 14 - 23 January. Wiley. pp. S8 - S8. ISSN: 0022-3417et al.
Santoro, A., Virmouni, SA., Paradies, E., Coa, VLV., Al-Mahdawi, S., Khoo, M., (2018) 'Effect of diazoxide on friedreich ataxia models'. Human Molecular Genetics, 27 (6). pp. 992 - 1001. ISSN: 0964-6906 Open Access Linket al.