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Summary

I have been at Brunel University London since the start of this century. This is when I established my own independent laboratory - The Laboratory of Nuclear and Genomic Health. Our research concerns how the genome is spatially organised, influenced and manipulated within its environment, the cell nucleus. The group has had a number of major advances and is currently focused on aspects of genome behaviour in replicative senescence, the premature ageing disease Hutchinson-Gilford Progeria Syndrome, host:pathogen interactions and female cancers. We are wish to understand how structures such as the nuclear lamina, nucleoskeleton and nuclear motors influence the functionality of the genome.

I also teach Cell Biology at levels 2 and 3, Developmental Biology at level 2, Gene Expression and Epigenetics and Cellular and Organismal Ageing at Masters level. The lab is always full of PhD, Masters and undergraduate students doing their various projects. 

I am also the Head of the Genome Engineering and Maintenance network established from the depth and interest in Genome Biology that has developed over time in Biosciences at Brunel. My other role is External Engagement where I organise all the external interactions we have in our division

Responsibility

Head of Genome Engineering and Mainenance Network

Module Coordinator for Gene Expression and Epigenetics Module 

External Engagement

PhD Supervisor 

Newest selected publications

Belak, Z., Pickering, J., Gillespie, Z., Audette, G., Eramian, M., Mitchell, J., et al. (2019) 'Genes responsive to rapamycin and serum deprivation are clustered on chromosomes and undergo re-organization within local chromatin environments.'. Biochemistry and Cell Biology, 98 (2). pp. 1 - 13. ISSN: 0829-8211

Journal article

Clements, C., Bikkul, M., Ofosu, W., Eskiw, C., Tree, D., Makarov, E., et al. (2019) 'Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways'. Biogerontology, 20 (3). pp. 337 - 358. ISSN: 1389-5729 Open Access Link

Journal article

Federico, C., Owoka, T., Ragusa, D., Sturiale, V., Caponnetto, D., Leotta, CG., et al. (2019) 'Deletions of Chromosome 7q Affect Nuclear Organization and HLXB9 Gene Expression in Hematological Disorders'. Cancers, 11 (4). pp. 585 - 585. ISSN: 2072-6694 Open Access Link

Journal article

Henry, M., Hawkins, R., Boyle, J. and Bridger, JM. (2019) 'The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organisation'. Frontiers in Genetics, 10 (JAN). pp. 623. ISSN: 1664-8021 Open Access Link

Journal article

Barravecchia, I., De Cesari, C., Pyankova, O., Scebba, F., Pè, M., Forcato, M., et al. (2019) 'A comprehensive molecular and morphological study of the effects of space flight on human capillary endothelial cells: sample quality assessment and preliminary results'.39th ISGP Meeting & ESA Life Sciences Meeting. Noordwijk, Netherlands. 16 - 22 June. Frontiers Media SA. ISSN: 0160-9009 Open Access Link

Conference paper
More publications(95)