Professor Joanna Bridger
Professor
Heinz Wolff 107
- Email: joanna.bridger@brunel.ac.uk
- Tel: +44 (0)1895 266272
Summary
I have been at Brunel University London since the start of this century. This is when I established my own independent laboratory - The Laboratory of Nuclear and Genomic Health. Our research concerns how the genome is spatially organised, influenced and manipulated within its environment, the cell nucleus. The group has had a number of major advances and is currently focused on aspects of genome behaviour in replicative senescence, the premature ageing disease Hutchinson-Gilford Progeria Syndrome, host:pathogen interactions and female cancers. We are wish to understand how structures such as the nuclear lamina, nucleoskeleton and nuclear motors influence the functionality of the genome.
Qualifications
HND BTEC Applied Biology 1985
BSc Microbiology and Genetics, UCL 1990
PhD in Zoology, Chromatin Organisation by the Nuclear Lamina. The University Dundee 1994
PGCert in L&T, Brunel University London 2002
MA in Cult Film and TV, Brunel University London, 2010
Responsibility
Director of the Centre for Genome Engineering and Mainenance
Centre for Genome Engineering and Maintenance | Brunel University London
Newest selected publications
Silahtaroglu, A., Bridger, JM. and Lei, EP. (2022) '3D genome organization'. Scientific Reports, 12 (1). pp. 1 - 2. ISSN: 2045-2322 Open Access Link
Barravecchia, I., De Cesari, C., Forcato, M., Scebba, F., Pyankova, O., Bridger, J., et al. (2021) 'Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways'. Cellular and Molecular Life Sciences, 79 (1). pp. 28. ISSN: 1420-682X
Federico, C., Bruno, F., Ragusa, D., Clements, CS., Brancato, D., Henry, MP., et al. (2021) 'Chromosomal Rearrangements and Altered Nuclear Organization: Recent Mechanistic Models in Cancer'. Cancers, 13 (22). pp. 1 - 13. ISSN: 2072-6694 Open Access Link
Smith, M., Yadav, S., Fagunloye, OG., Pels, NA., Horton, DA., Alsultan, N., et al. (2021) 'Piwi silencing mechanism involving the retrotransposon nimbus orchestrates resistance to infection with schistosoma mansoni in the snail vector, biomphalaria glabrata'. PLoS Neglected Tropical Diseases, 15 (9). pp. 1 - 28. ISSN: 1935-2727 Open Access Link
Mehta, I., Riyahi, K., Torres Pereira, R., Meaburn, K., Figgitt, M., Kill, I., et al. (2021) 'Interphase Chromosomes in Replicative Senescence: chromosome positioning as a senescence biomarker and the lack of nuclear motor-driven chromosome repositioning in senescent cells.'. Frontiers in Cell and Developmental Biology, 9. pp. 1 - 18. ISSN: 2296-634X Open Access Link