I have been at Brunel University London since the start of this century. This is when I established my own independent laboratory - The Laboratory of Nuclear and Genomic Health. Our research concerns how the genome is spatially organised, influenced and manipulated within its environment, the cell nucleus. The group has had a number of major advances and is currently focused on aspects of genome behaviour in replicative senescence, the premature ageing disease Hutchinson-Gilford Progeria Syndrome, host:pathogen interactions and female cancers. We are wish to understand how structures such as the nuclear lamina, nucleoskeleton and nuclear motors influence the functionality of the genome.
I also teach Cell Biology at levels 2 and 3, Developmental Biology at level 2, Gene Expression and Epigenetics and Cellular and Organismal Ageing at Masters level. The lab is always full of PhD, Masters and undergraduate students doing their various projects.
I am also the Head of the Genome Engineering and Maintenance network established from the depth and interest in Genome Biology that has developed over time in Biosciences at Brunel. My other role is External Engagement where I organise all the external interactions we have in our division
Head of Genome Engineering and Mainenance Network
Module Coordinator for Gene Expression and Epigenetics Module
Newest selected publications
Mehta, I., Riyahi, K., Torres Pereira, R., Meaburn, K., Figgitt, M., Kill, I., (2021) 'Interphase Chromosomes in Replicative Senescence: chromosome positioning as a senescence biomarker and the lack of nuclear motor-driven chromosome repositioning in senescent cells.'. Frontiers in Cell and Developmental Biology, 9. pp. 1 - 18. ISSN: 2296-634X Open Access Linket al.
Godwin, L., Bridger, J. and Foster, H. (2021) 'Fluorescence in situ Hybridization on DNA Halo Preparations to reveal whole Chromosomes, Telomeres and Gene Loci'. Journal of Vizualized Experiments, 2021 (169). pp. 1 - 22. ISSN: 1940-087X Open Access Link
Almendáriz-Palacios, C., Gillespie, ZE., Janzen, M., Martinez, V., Bridger, JM., Harkness, TAA., (2020) 'The Nuclear Lamina: Protein Accumulation Disease and Clearance'. Biomedicines, 8 (7). pp. 1 - 23. ISSN: 2227-9059 Open Access Linket al.
Belak, ZR., Pickering, JA., Gillespie, ZE., Audette, G., Eramian, M., Mitchell, JA., (2019) 'Genes responsive to rapamycin and serum deprivation are clustered on chromosomes and undergo re-organization within local chromatin environments.'. Biochemistry and Cell Biology, 98 (2). pp. 178 - 190. ISSN: 0829-8211 Open Access Linket al.
Clements, CS., Bikkul, MU., Ofosu, W., Eskiw, C., Tree, D., Makarov, E., (2019) 'Presence and distribution of progerin in HGPS cells is ameliorated by drugs that impact on the mevalonate and mTOR pathways'. Biogerontology, 20 (3). pp. 337 - 358. ISSN: 1389-5729 Open Access Linket al.