I have been at Brunel University London since the start of this century. This is when I established my own independent laboratory - The Laboratory of Nuclear and Genomic Health. Our research concerns how the genome is spatially organised, influenced and manipulated within its environment, the cell nucleus. The group has had a number of major advances and is currently focused on aspects of genome behaviour in replicative senescence, the premature ageing disease Hutchinson-Gilford Progeria Syndrome, host:pathogen interactions and female cancers. We are wish to understand how structures such as the nuclear lamina, nucleoskeleton and nuclear motors influence the functionality of the genome.
I also teach Cell Biology at levels 2 and 3, Developmental Biology at level 2, Gene Expression and Epigenetics and Cellular and Organismal Ageing at Masters level. The lab is always full of PhD, Masters and undergraduate students doing their various projects.
I am also the Head of the Genome Engineering and Maintenance network established from the depth and interest in Genome Biology that has developed over time in Biosciences at Brunel. My other role is External Engagement where I organise all the external interactions we have in our division
Head of Genome Engineering and Mainenance Network
Module Coordinator for Gene Expression and Epigenetics Module
Newest selected publications
Henry, M., Hawkins, R., Boyle, J. and Bridger, JM. (2019) 'The Genomic Health of Human Pluripotent Stem Cells: Genomic Instability and the Consequences on Nuclear Organisation'. Frontiers in Genetics, 9. pp. 623. ISSN: 1664-8021 Open Access Link
BARRAVECCHIA1, IVANA., De Cesari, C., Pyankova, O., Scebba, F., Pè, M., Forcato, M., (2018) 'A comprehensive molecular and morphological study of the effects of space flight on human capillary endothelial cells: sample quality assessment and preliminary results.'.39th ISGP Meeting & ESA Life Sciences Meeting. Noordwijk, Netherlands. 13 - 22 June. Frontiers. ISSN: 0160-9009et al.
Mehmet, B., Faragher, R., Worthington, G., Meinke, P., Kerr, A., Sammy, A., (2018) 'Telomere elongation through hTERT immortalisation leads to chromosome repositioning in control cells and genomic instability in Hutchinson-Gilford Progeria syndrome fibroblasts, expressing a novel SUN1 isoform.'. Genes, Chromosomes and Cancer. ISSN: 1045-2257 Open Access Linket al.
Bridger, JM., Brindley, PJ. and Knight, M. (2018) 'The snail Biomphalaria glabrata as a model to interrogate the molecular basis of complex human diseases'. PLoS Neglected Tropical Diseases, 12 (8). pp. e0006552. ISSN: 1935-2727 Open Access Link
Bridger, JM. (2018) 'FARNESYLTRANSFERASE INHIBITOR AND RAPAMYCIN CORRECT ABBERANT GENOME ORGANISATION AND DNA DAMAGE IN HUTCHINSON-GILFORD PROGERIA SYNDROME FIBROBLASTS.'. Biogerontology, 19 (6). pp. 1 - 24. ISSN: 1389-5729 Open Access Link