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Professor Joanna Bridger


Our research concerns how the genome is spatially organised, influenced and manipulated within its environment, the cell nucleus. The group has had a number of major advances and is currently focused on aspects of genome behaviour in replicative senescence, the premature ageing disease Hutchinson-Gilford Progeria Syndrome, host:pathogen interactions and female cancers. We are wish to understand how structures such as the nuclear lamina, nucleoskeleton and nuclear motors influence the functionality of the genome in health and disease.

Our newest interest is in how the genome can be organised and regulated in low gravity situations and space. 


HND BTEC Applied Biology 1985

BSc Microbiology and Genetics, UCL 1990 

PhD in Zoology, Chromatin Organisation by the Nuclear Lamina. The University Dundee 1994

PGCert in L&T, Brunel University London 2002

MA in Cult Film and TV, Brunel University London, 2010


Director of the Centre for Genome Engineering and Maintenance (cenGEM)

Co-head Brunel Space Travel and Applied Research (B-STAR) Network 

Centre for Genome Engineering and Maintenance | Brunel University London

Newest selected publications

Garimberti, E., Federico, C., Ragusa, D., Bruno, F., Saccone, S., Bridger, JM. and et al. (2024) 'Alterations in Genome Organization in Lymphoma Cell Nuclei due to the Presence of the t(14;18) Translocation'. International Journal of Molecular Sciences, 25 (4). pp. 1 - 12. ISSN: 1661-6596 Open Access Link

Journal article

Schirmer, EC. and Bridger, JM. (2023) 'Editorial: Is aberrant genome organization a cause or consequence of specific diseases?'. Frontiers in Cell and Developmental Biology, 11. pp. 1 - 2. ISSN: 2296-634X Open Access Link

Journal article

Silahtaroglu, A., Bridger, JM. and Lei, EP. (2022) '3D genome organization'. Scientific Reports, 12 (1). pp. 1 - 2. ISSN: 2045-2322 Open Access Link

Journal article

Bridger, JM., Torres Pereira, R., Pina, C., Tosi, S. and Lewis, A. (2022) 'Alterations to Genome Organisation in Stem Cells, their Differentiation and Associated Diseases', in Kloc, M. and Kubiak, JZ. (eds.) Nuclear, Chromosomal, and Genomic Architecture in Biology and Medicine. Cham, Switzerland : Springer, Cham. , 70. pp. 71 - 102. ISBN 10: 3-031-06573-5. ISBN 13: 978-3-031-06572-9. Open Access Link

Book chapter

Barravecchia, I., De Cesari, C., Forcato, M., Scebba, F., Pyankova, O., Bridger, J., et al. (2021) 'Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways'. Cellular and Molecular Life Sciences, 79 (1). pp. 1 - 29. ISSN: 1420-682X Open Access Link

Journal article
More publications(106)