I have been at Brunel University London since the start of this century. This is when I established my own independent laboratory - The Laboratory of Nuclear and Genomic Health. Our research concerns how the genome is spatially organised, influenced and manipulated within its environment, the cell nucleus. The group has had a number of major advances and is currently focused on aspects of genome behaviour in replicative senescence, the premature ageing disease Hutchinson-Gilford Progeria Syndrome, host:pathogen interactions and female cancers. We are wish to understand how structures such as the nuclear lamina, nucleoskeleton and nuclear motors influence the functionality of the genome.
I also teach Cell Biology at levels 2 and 3, Developmental Biology at level 2, Gene Expression and Epigenetics and Cellular and Organismal Ageing at Masters level. The lab is always full of PhD, Masters and undergraduate students doing their various projects.
I am also the Head of the Genome Engineering and Maintenance network established from the depth and interest in Genome Biology that has developed over time in Biosciences at Brunel. My other role is External Engagement where I organise all the external interactions we have in our division
Head of Genome Engineering and Mainenance Network
Module Coordinator for Gene Expression and Epigenetics Module
Newest selected publications
Barravecchia, I., De Cesari, C., Forcato, M., Scebba, F., Pyankova, O., Bridger, J., (2022) 'Microgravity and space radiation inhibit autophagy in human capillary endothelial cells, through either opposite or synergistic effects on specific molecular pathways'. Cellular and Molecular Life Sciences, 79 (1). pp. 28. ISSN: 1420-682Xet al.
Federico, C., Bruno, F., Ragusa, D., Clements, CS., Brancato, D., Henry, MP., (2021) 'Chromosomal Rearrangements and Altered Nuclear Organization: Recent Mechanistic Models in Cancer'. Cancers, 13 (22). pp. 1 - 13. ISSN: 2072-6694 Open Access Linket al.
Smith, M., Yadav, S., Fagunloye, OG., Pels, NA., Horton, DA., Alsultan, N., (2021) 'Piwi silencing mechanism involving the retrotransposon nimbus orchestrates resistance to infection with schistosoma mansoni in the snail vector, biomphalaria glabrata'. PLoS Neglected Tropical Diseases, 15 (9). pp. 1 - 28. ISSN: 1935-2727 Open Access Linket al.
Mehta, I., Riyahi, K., Torres Pereira, R., Meaburn, K., Figgitt, M., Kill, I., (2021) 'Interphase Chromosomes in Replicative Senescence: chromosome positioning as a senescence biomarker and the lack of nuclear motor-driven chromosome repositioning in senescent cells.'. Frontiers in Cell and Developmental Biology, 9. pp. 1 - 18. ISSN: 2296-634X Open Access Linket al.
Godwin, L., Bridger, J. and Foster, H. (2021) 'Fluorescence in situ Hybridization on DNA Halo Preparations to reveal whole Chromosomes, Telomeres and Gene Loci'. Journal of Vizualized Experiments, 2021 (169). pp. 1 - 22. ISSN: 1940-087X Open Access Link