Sibylle Ermler is a Research Fellow in Human Toxicology in the Department of Life Sciences. She has expertise in the impact of endocrine disrupting chemicals (EDCs) and genotoxicants on human and environmental health. Her research interests are in male and female reproductive health, metabolic disorders, and the developmental origins of health and disease. Furthermore, she is an expert in mixture toxicology with an interest in the translation of (mixture-) toxicology into chemical risk assessment. Sibylle’s research has a focus on the development and application of novel in vitro approaches with the aim of creating human relevant models for human disease, and reducing the requirement for animal testing. Additional interdisciplinary research interests include the impact of climate change on food systems and on human development and health.
2011-present: Research Fellow, Institute of Environment, Health and Societies, Brunel University
2007-2011: Postdoctoral Research Fellow, Centre for Toxicology, School of Pharmacy, London
2006: Dr. rer. nat. (PhD) Faculty of Biosciences, Ruperto-Carola University, Heidelberg, Thesis title: “The Role of the Telomeric Repeat Binding Factor 2 (TRF2) in Normal and Tumour Cells”, conducted at the German Cancer Research Center, Heidelberg, Germany
2001: Diploma in environmental and chemical engineering/biotechnology, Fachhochschule Furtwangen, Germany Dissertation title: “Development of a Genotoxicity Assay for High Throughput Screening”, conducted at the University of Manchester Institute of Science and Technology, Manchester, UK Awarded with the “Aesculap prize for a particularly innovative diploma thesis at the University of Applied Sciences Furtwangen with an industry-relevant topic“
2021-present : Researchers Senate Representative
Newest selected publications
Kassotis, CD., Hoffman, K., Völker, J., Pu, Y., Veiga-Lopez, A., Kim, SM., (2021) 'Reproducibility of adipogenic responses to metabolism disrupting chemicals in the 3T3-L1 pre-adipocyte model system: An interlaboratory study'. Toxicology, 461. pp. 152900 - 152900. ISSN: 0300-483Xet al.
Scholze, M., Taxvig, C., Kortenkamp, A., Boberg, J., Christiansen, S., Svingen, T., (2020) 'Quantitative in Vitro to in Vivo Extrapolation (QIVIVE) for Predicting Reduced Anogenital Distance Produced by Anti-Androgenic Pesticides in a Rodent Model for Male Reproductive Disorders'. Environmental health perspectives, 128 (11). pp. 1 - 17. ISSN: 0091-6765 Open Access Linket al.
Martin, O., Scholze, M., Ermler, S., McPhie, J., Bopp, SK., Kienzler, A., (2020) 'Ten years of research on synergisms and antagonisms in chemical mixtures: A systematic review and quantitative reappraisal of mixture studies'. Environment International, 146. pp. 106206 - 106206. ISSN: 0160-4120 Open Access Linket al.
Legler, J., Zalko, D., Jourdan, F., Jacobs, M., Fromenty, B., Balaguer, P., (2020) 'The goliath project: Towards an internationally harmonised approach for testing metabolism disrupting compounds'. International Journal of Molecular Sciences, 21 (10). pp. 3480 - 3480. ISSN: 1661-6596 Open Access Linket al.
Martin, O., Ermler, S., Baynes, A. and Mcphie, J. (2020) 'Data collection in support of the Endocrine Disruption (ED) assessment for non‐target vertebrates'. Place of publication: European Food Standard Authority. Available at: https://doi.org/10.2903/sp.efsa.2020.EN-1849. ISSN: 2397-8325 Open Access Link