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Professor Andreas Kortenkamp

Professor Andreas Kortenkamp
Theme Leader / Professor - Human Molecular Toxicology

Summary

Traditional chemicals risk assessment has a quite artificial orientation: It treats chemicals as if they act in isolation, when in reality there is exposure to multiple substances. For more than 15 years, our team have been engaged in efforts to find ways of improving risk assessment by taking “cocktail effects” into account. This work has proceeded in stages: Firstly, when we have information about the toxicity of individual mixture components, is it possible to predict the effects of the combination? Working with mixtures of endocrine disrupting chemicals we have shown that this is achievable. Secondly, what is the composition of mixtures of environmental relevance, and what effects do they produce? Work on this aspect of the mixtures issue is currently proceeding in our group. We are also interested in making an impact on chemical regulation by addressing the questions: Which chemicals should be grouped together for mixtures risk assessment? What are scientifically sound grouping criteria?

We have prepared scientific reports for the European Commission, including the State of the Art Report on Mixture Toxicology. Currently we are writing a State of the Art Assessment for Endocrine Disrupters, a project also commissioned by the European Commission.

Another research interest is in unravelling the details of estrogen signalling and estrogen-mediated effects with a view to understanding hormonal cancers, especially breast cancer. Here, I closely collaborate with Dr Elisabete Silva.

Qualifications

1983: Degree in Chemistry, Philosophy and Educational Sciences from University of Muenster, Germany 1989: PhD (with distinction) from Bremen University, Bremen, Germany

Career

  • 1990-1991: Post-doctoral Fellow at Queen Mary London, University of London.
  • 1991-2000: Lecturer in Environmental Toxicology, School of Pharmacy, University of London, London.
  • 2000-2005: Senior Lecturer, School of Pharmacy, University of London, London.
  • 2005-2007: Reader and Head of Centre for Toxicology, School of Pharmacy, University of London, London.
  • 2007-2011: Professor for Molecular Toxicology, Head of Centre for Toxicology, School of Pharmacy, University of London, London.
  • 2011-present: Professor in the Institute for the Environment, Brunel University.

Newest selected publications

Kortenkamp, A., Axelstad, M., Baig, AH., Bergman, Å., Bornehag, C-G., Cenijn, P., et al. (2020) 'Removing Critical Gaps in Chemical Test Methods by Developing New Assays for the Identification of Thyroid Hormone System-Disrupting Chemicals—The ATHENA Project'. International Journal of Molecular Sciences, 21 (9). pp. 3123 - 3123. ISSN: 1661-6596 Open Access Link

Journal article

Apel, P., Kortenkamp, A., Koch, HM., Vogel, N., Rüther, M., Kasper-Sonnenberg, M., et al. (2020) 'Time course of phthalate cumulative risks to male developmental health over a 27-year period: Biomonitoring samples of the German Environmental Specimen Bank'. Environment International, 137 (April 2020). pp. 105467 - 105467. ISSN: 0160-4120 Open Access Link

Journal article

Hamers, T., Kortenkamp, A., Scholze, M., Molenaar, D., Cenijn, PH. and Weiss, JM. (2020) 'Transthyretin-Binding Activity of Complex Mixtures Representing the Composition of Thyroid-Hormone Disrupting Contaminants in House Dust and Human Serum'. Environmental health perspectives, 128 (1). pp. 17015 - 17015. ISSN: 0091-6765 Open Access Link

Journal article

Kortenkamp, A. and Koch, HM. (2019) 'Refined reference doses and new procedures for phthalate mixture risk assessment focused on male developmental toxicity'. International Journal of Hygiene and Environmental Health, 224. pp. 113428 - 113428. ISSN: 1438-4639 Open Access Link

Journal article

Brack, W., Ait-Aissa, S., Altenburger, R., Cousins, I., Dulio, V., Escher, B., et al. (2019) 'Let us empower the WFD to prevent risks of chemical pollution in European rivers and lakes'. Environmental Sciences Europe, 31 (1). ISSN: 2190-4707

Journal article
More publications(147)