Professor Andreas Kortenkamp
Theme Leader / Professor - Human Molecular Toxicology
SummaryTraditional chemicals risk assessment has a quite artificial orientation: It treats chemicals as if they act in isolation, when in reality there is exposure to multiple substances. For more than 15 years, our team have been engaged in efforts to find ways of improving risk assessment by taking “cocktail effects” into account. This work has proceeded in stages: Firstly, when we have information about the toxicity of individual mixture components, is it possible to predict the effects of the combination? Working with mixtures of endocrine disrupting chemicals we have shown that this is achievable. Secondly, what is the composition of mixtures of environmental relevance, and what effects do they produce? Work on this aspect of the mixtures issue is currently proceeding in our group. We are also interested in making an impact on chemical regulation by addressing the questions: Which chemicals should be grouped together for mixtures risk assessment? What are scientifically sound grouping criteria?
We have prepared scientific reports for the European Commission, including the State of the Art Report on Mixture Toxicology. Currently we are writing a State of the Art Assessment for Endocrine Disrupters, a project also commissioned by the European Commission.
Another research interest is in unravelling the details of estrogen signalling and estrogen-mediated effects with a view to understanding hormonal cancers, especially breast cancer. Here, I closely collaborate with Dr Elisabete Silva.
Qualifications1983: Degree in Chemistry, Philosophy and Educational Sciences from University of Muenster, Germany 1989: PhD (with distinction) from Bremen University, Bremen, Germany
- 1990-1991: Post-doctoral Fellow at Queen Mary London, University of London.
- 1991-2000: Lecturer in Environmental Toxicology, School of Pharmacy, University of London, London.
- 2000-2005: Senior Lecturer, School of Pharmacy, University of London, London.
- 2005-2007: Reader and Head of Centre for Toxicology, School of Pharmacy, University of London, London.
- 2007-2011: Professor for Molecular Toxicology, Head of Centre for Toxicology, School of Pharmacy, University of London, London.
- 2011-present: Professor in the Institute for the Environment, Brunel University.
Newest selected publications
Brack, W., Ait-Aissa, S., Altenburger, R., Cousins, I., Dulio, V., Escher, B., (2019) 'Let us empower the WFD to prevent risks of chemical pollution in European rivers and lakes'. Environmental Sciences Europe, 31 (1). ISSN: 2190-4707et al.
Kortenkamp, A., Faust, M., Backhaus, T., Altenburger, R., Scholze, M., Müller, C., (2019) 'Mixture risks threaten water quality: the European Collaborative Project SOLUTIONS recommends changes to the WFD and better coordination across all pieces of European chemicals legislation to improve protection from exposure of the aquatic environment to multiple pollutants'. Environmental Sciences Europe, 31 (1). ISSN: 2190-4707et al.
Posthuma, L., Altenburger, R., Backhaus, T., Kortenkamp, A., Müller, C., Focks, A., (2019) 'Improved component-based methods for mixture risk assessment are key to characterize complex chemical pollution in surface waters'. Environmental Sciences Europe, 31 (1). ISSN: 2190-4707et al.
Faust, M., Backhaus, T., Altenburger, R., Dulio, V., van Gils, J., Ginebreda, A., (2019) 'Prioritisation of water pollutants: the EU Project SOLUTIONS proposes a methodological framework for the integration of mixture risk assessments into prioritisation procedures under the European Water Framework Directive'. Environmental Sciences Europe, 31 (1). ISSN: 2190-4707et al.
Brack, W., Ait-Aissa, S., Backhaus, T., Birk, S., Barceló, D., Burgess, R., (2019) 'Strengthen the European collaborative environmental research to meet European policy goals for achieving a sustainable, non-toxic environment'. Environmental Sciences Europe, 31 (1). ISSN: 2190-4707et al.