Dr Annabelle Lewis
Senior Lecturer in Biomedical Sciences
Heinz Wolff 113a
- Email: annabelle.lewis@brunel.ac.uk
- Tel: +44 (0)1895 266607
Summary
I am a lecturer in biomedical sciences and run a research laboratory. My research interest is cancer genetics and gene regulation, focusing on colorectal cancer. We use cell lines and animal models to study how common variants in the human genome affect the expression of key cancer genes, and increase the risk of an individual developing cancer.
Qualifications
PhD in Developmental Genetics and Imprinting (The Babraham Institute, University of Cambridge)
BA in Natural Sciences (University of Cambridge)
Newest selected publications
O'Cathail, SM., Wu, CH., Lewis, A., Holmes, C., Hawkins, MA. and Maughan, T. (2020) 'NRF2 metagene signature is a novel prognostic biomarker in colorectal cancer'. Cancer Genetics, 248-249. pp. 1 - 10. ISSN: 2210-7762
Lewis, A., Russell, H., Kedzierska, K., Buchanan, D., Thomas, R., Tham, E., et al. (2020) 'The MLH1 polymorphism rs1800734 and risk of endometrial cancer with microsatellite instability'. Clinical Epigenetics, 12 (1). pp. 1 - 9. ISSN: 1868-7075 Open Access Link
Lewis, A. (2019) 'CRISPR-Cas9 causes chromosomal instability and re-arrangements in cancer cell lines, detectable by cytogenetic methods'. The CRISPR-Journal, 2 (6). pp. 406 - 416. ISSN: 2573-1599 Open Access Link
Thomas, R., Trapani, D., Goodyer-Sait, L., Tomkova, M., Fernandez-Rozadilla, C., Sahnane, N., et al. (2019) 'The polymorphic variant rs1800734 influences methylation acquisition and allele-specific TFAP4 binding in the MLH1 promoter leading to differential mRNA expression'. Scientific Reports, 9 (1). pp. 13463. ISSN: 2045-2322 Open Access Link
Irshad, S., Bansal, M., Guarnieri, P., Davis, H., Al Haj Zen, A., Baran, B., et al. (2017) 'Bone morphogenetic protein and Notch signalling crosstalk in poor-prognosis, mesenchymal-subtype colorectal cancer'. Journal of Pathology, 242 (2). pp. 178 - 192. ISSN: 0022-3417 Open Access Link