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Dr Cristina Pina

Dr Cristina Pina
Lecturer in Biomedical Sciences

Summary

I am a clinically-trained research scientist working in the field of cancer epigenetics. I am fascinated by the mechanisms through which cells diversify their molecular composition, and consequently vary their morphology and their function, to make organs, regenerate tissues, and produce tumours. While some of those diversification mechanisms rely on genetic mutations, others explore the way in which cells read their genes to produce the RNA and proteins that underlie cell function. The latter are referred to as epigenetic mechanisms.

My research is focused on understanding and manipulating epigenetic mechanisms to alter cell identity, and in particular, it aims to probe their role in cancer evolution in an attempt to unveil new therapies.

Qualifications

DPhil Clinical Medicine, University of Oxford, 2008

Medical Doctor, Full registration, Ordem dos Medicos Portuguesa, 2000

MBBS (Licenciatura em Medicina), University of Lisbon, 1998

Responsibility

I am a Lecturer in Biomedical Sciences with Research and Teaching resposibilities.

Newest selected publications

Domingues, AF., Kulkarni, R., Giotopoulos, G., Gupta, S., Vinnenberg, L., Arede, L., et al. (2020) 'Loss of Kat2a Enhances Transcriptional Noise and depletes Acute Myeloid Leukaemia Stem-like Cells'. eLife, 9. ISSN: 2050-084X Open Access Link

Journal article

Moris, N., Edri, S., Seyres, D., Kulkarni, R., Domingues, AF., Balayo, T., et al. (2018) 'Histone Acetyltransferase KAT2A Stabilizes Pluripotency with Control of Transcriptional Heterogeneity'. Stem Cells, 36 (12). pp. 1828 - 1838. ISSN: 1066-5099 Open Access Link

Journal article

Tzelepis, K., Koike-Yusa, H., De Braekeleer, E., Li, Y., Metzakopian, E., Dovey, OM., et al. (2016) 'A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia'. Cell Reports, 17 (4). pp. 1193 - 1205. ISSN: 2211-1247 Open Access Link

Journal article

Moris, N., Pina, C. and Arias, AM. (2016) 'Transition states and cell fate decisions in epigenetic landscapes'. Nature Reviews Genetics, 17 (11). pp. 693 - 703. ISSN: 1471-0056

Journal article

Pina, C., Teles, J., Fugazza, C., May, G., Wang, D., Guo, Y., et al. (2015) 'Single-Cell Network Analysis Identifies DDIT3 as a Nodal Lineage Regulator in Hematopoiesis'. Cell Reports, 11 (10). pp. 1503 - 1510. ISSN: 2211-1247

Journal article
More publications(6)