I am a clinically-trained research scientist working in the field of cancer epigenetics. I am fascinated by the mechanisms through which cells diversify their molecular composition, and consequently vary their morphology and their function, to make organs, regenerate tissues, and produce tumours. While some of those diversification mechanisms rely on genetic mutations, others explore the way in which cells read their genes to produce the RNA and proteins that underlie cell function. The latter are referred to as epigenetic mechanisms.
My research is focused on understanding and manipulating epigenetic mechanisms to alter cell identity, and in particular, it aims to probe their role in cancer evolution in an attempt to unveil new therapies.
DPhil Clinical Medicine, University of Oxford, 2008
Medical Doctor, Full registration, Ordem dos Medicos Portuguesa, 2000
MBBS (Licenciatura em Medicina), University of Lisbon, 1998
I am a Lecturer in Biomedical Sciences with Research and Teaching resposibilities.
Newest selected publications
Pina, C. and Arede, L. (2021) 'Buffering noise: KAT2A modular contributions to stabilization of transcription and cell identity in cancer and development'. Experimental Hematology, 93. pp. 1 - 22. ISSN: 0301-472X Open Access Link
Arede, L., Foerner, E., Wind, S., Kulkarni, R., Domingues, AF., Kleinwaechter, S., (Accepted) 'Unique roles of ATAC and SAGA - KAT2A complexes in normal and malignant hematopoiesis'. .et al.
Domingues, AF., Kulkarni, R., Giotopoulos, G., Gupta, S., Vinnenberg, L., Arede, L., (2020) 'Loss of Kat2a Enhances Transcriptional Noise and depletes Acute Myeloid Leukaemia Stem-like Cells'. eLife, 9. ISSN: 2050-084X Open Access Linket al.
Moris, N., Edri, S., Seyres, D., Kulkarni, R., Domingues, AF., Balayo, T., (2018) 'Histone Acetyltransferase KAT2A Stabilizes Pluripotency with Control of Transcriptional Heterogeneity'. Stem Cells, 36 (12). pp. 1828 - 1838. ISSN: 1066-5099 Open Access Linket al.
Tzelepis, K., Koike-Yusa, H., De Braekeleer, E., Li, Y., Metzakopian, E., Dovey, OM., (2016) 'A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia'. Cell Reports, 17 (4). pp. 1193 - 1205. ISSN: 2211-1247 Open Access Linket al.