Using mindfulness to reduce schizophrenia vulnerability

We are all confronted with an overwhelming array of sensory stimuli and are required to filter out what is most useful and salient, and discard unwanted information. Leading theorists have argued that schizophrenia may result in part from an inability to filter information. Yet, having a more open information processing style (i.e. less filtering) has also been linked to creativity and originality of thought, which is both an aesthetic and pragmatic blessing for an individual and society. Indeed, schizophrenia and creativity have been linked by previous research. Antipsychotic medication, the first line of treatment for psychosis and schizophrenia, is known to dampen down more open processing, potentially reducing conditions promoting creativity. Our research on expert meditators showed that mindfulness practice is associated with lower suspiciousness and paranoia (the strongest risk factor in psychosis-prone individuals for converting to psychosis) in the presence of decreased filtering. In this project, we examine if mindfulness training in psychosis-prone individuals reduces schizophrenia vulnerability (suspiciousness/paranoia), whilst preserving decreased filtering thought to underlie heightened creativity.

The project seeks, for the first time, to i) ascertain whether there is a link between high positive schizotypy (linked to psychosis-proneness), creativity, and reduced information filtering (as measured by the startle habituation paradigm); and ii) pilot a mindfulness-based intervention for reducing suspiciousness/paranoia with individuals with high positive schizotypy.  


Meet the Principal Investigator(s) for the project

Dr Elena Antonova
Dr Elena Antonova - I am a Reader in Contemplative Neuroscience in the Department of Psychology, College of Health, Medicine and Life Sciences. I obtained a BSc in Psychology in 2000 from the University College London, UK, and a PhD in Cognitive Psychology in 2004 from the Institute of Psychiatry, Psychology and Neuroscience, King's College London, UK. My main area of research interest and expertise is the neuroscience of mindfulness, with a focus on investigating the effects of long-term mindfulness meditation practice using psychophysiology and neuroimaging methods, and applying the insights gained from this research to the prevention of mental illness as well as the promotion of mental health and wellbeing. I have been actively involved with the Mind and Life Institute since 2011 and with Mind and Life Europe since 2013, organisations that catalyse interdisciplinary scientific research into the effects of contemplative practices. In 2017, I was elected a Mind & Life Research Fellow for my contribution to contemplative science - the highest honorific recognition in my research field. I also actively engage with the ontological foundations of cognitive neuroscience, specifically the mind–brain relationship, and of the sciences more generally.

Related Research Group(s)

man with paint

Embodiment in Academic and Professional Practice - Development of an enhanced awareness of bodies as sensors of crucial information about ourselves and our reality; Enhancing our performance as human beings, practitioners, researchers and educators.

brain scan

Cognitive and Clinical Neuroscience - Fundamental and applied research into brain function using techniques such as functional magnetic resonance imaging (fMRI), electroencephalography (EEG), electromyography (EMG), eye-tracking, transcranial magnetic stimulation (TMS), transcranial direct-current stimulation (tDCS), infrared thermography together with psychophysics and cognitive behavioural paradigms in health and disease.


Partnering with confidence

Organisations interested in our research can partner with us with confidence backed by an external and independent benchmark: The Knowledge Exchange Framework. Read more.


Project last modified 14/11/2023