Biomedical Sciences research projects Our research-led academics are carrying out some of the most important scientific work to better understand, treat and develop cures for a wide range of human diseases. Below are some examples of the projects we have completed or are currently working on. Does CRISPR-Cas9 treatment cause DNA damage in cancer cells? Ongoing Evolution of religious and secular medical treatments Ongoing Pharmacological strategies for resolution of inflammation Ongoing Investigating thrombo-inflammation in disease Ongoing Manipulating our immune system to protect against ageing Ongoing Common genetic variants that increase the risk of cancer Ongoing Radiation exposure and heritable genetic effects Ongoing Using mindfulness to reduce schizophrenia vulnerability Completed The role of early growth protein molecules in preventing autoimmune disease and cancer Ongoing Metabolic reprogramming of skin microenvironment for improved BCG vaccine efficacy Completed Promoting inflammation resolution in sickle cell disease Ongoing The role of the oncoprotein MYB in the head and neck cancer adenoid cystic carcinoma Ongoing Determinants and mechanisms involved in alcohol consumption and its health consequences Completed Understanding the effects of inflammation on brain and behaviour Ongoing Generation of novel approaches for testing metabolism disrupting chemicals Ongoing Understanding of the mechanisms underlying adverse effects of pharmaceuticals Completed Understanding the effects of cyclo-oxygenase inhibition in the zebrafish Ongoing Investigating the dysfunction of the cerebral microvasculature in sickle cell disease Ongoing Innate immunity in bovine tuberculosis Completed Host-pathogen interactions in tuberculosis Ongoing Human endogenous factors in the control of mycobacterial infection Ongoing COVID-19 and Relationships Study Completed Protect mental health COVID-19 study Completed How do cells divide? Chromatin re-organisation from mitosis to G1 Ongoing Investigating the role of CDCA2 molecule in neuroblastoma Ongoing Community sport and inequalities Ongoing Pandemic crisis prediction and management Ongoing Knowledge exchange on healthcare big data analytics Ongoing Sustainable livelihoods in refugee resettlements Ongoing Petri nets for multiscale Systems Biology Completed Dissecting Body Representations: A Multi-dimensional Approach Completed Attending mindfully: A psychophysiology study of sensory processing in meditators Ongoing Childhood maltreatment: emotional consequences and potential intervention Completed Air pollution, brain health and wellbeing in India Completed Writing in the Digital Age-Keyboard versus Pen in Adolescents with Handwriting Difficulties Ongoing Elucidation of the metabolic signature of Friedreich's ataxia Completed Every Litter Matters Completed Exploring behavioural change in Nigeria and Sri Lanka Completed Perceptions of plastics pollution in Sri Lanka and Vietnam Completed Plastic pollution in Nigeria Completed Breathing muscle strength in healthy children Completed Artificial intelligent system for oncological volumetric medical PET classification Completed Biometric identification using gait Completed 3D Software Mapping For Osteoarthritis Pain Self-Management Completed Gestalt grouping and perceptual averaging to boost memory capacity Completed A deep learning model for global camera trap labelling Ongoing Retinal image analysis Ongoing Environmental Matters Shorts aka Eat My Shorts Ongoing Visual and emotional processing in early Parkinson's disease Ongoing Gender Differences in Multitasking Ongoing Statistical modelling of multi-omics data Completed Assessing endocrine disruption in birds, fish and amphibians Completed Diabetes UK: Understanding physical activity Completed Side effects of gene therapy vectors Completed Developing a goal orientated assessment & outcome measure for children's wheelchair basketball Completed Health and well-being of adults with cerebral palsy Completed Innovative techniques for precise, atraumatic placement of cochlear implant (CI) Ongoing Modelling adenoid cystic carcinoma in a mouse Completed The Period Poverty Project Ongoing A new cell and gene therapy approach for Friedreich's ataxia Ongoing Developing a UV ballast water treatment system with real-time monitoring Completed Scientific underpinnings of the clinical assessment of patellofemoral alignment Completed Biomechanical and sociological factors influencing pain and physical activity in children Completed Assessment of injury risk factors and mechanisms in elite netball Completed Quantification of carbon emissions and savings in smart grids Completed Sustainable Digital Furniture Manufacturing Using 3D Printing Robot Completed Artificial Intelligence for Optimisation and Demand Side Response of Built Environment Management Completed Innovative Quality Engineering and Smart Technology Ongoing Vascular stiffness and distensibility in exercising humans Completed Optimising biomechanics of throwing performance Completed The impact of hydration status on heat acclimation adaptations Completed Circulating microvesicles responses to exercise and heat stress Completed Bike riding biomechanics and performance in children Completed Assessing the functional trajectories of people with chronic critical illness Completed Acute cardiovascular responses to slow and deep breathing Completed The impact of task complexity, cognitive load and anxiety on driving Completed The relationship between gaze and information pickup during action observation Completed The effects of sonification on motor imagery ability Completed Anticipation in Soccer Completed Decision Making in Gaelic Football Ongoing Road cycling behaviour of young adults Completed Improving services for electrically powered indoor/outdoor chair (EPIOC) users Completed Preclinical studies of the inherited disease Friedreich ataxia Completed Respiratory responses to exercise in athletes with spinal cord injury Completed When reading misfires: the case for letter confusability Completed Effects of creatine supplementation on the airways of youth elite football players Completed Medicines and diagnostics in Mozambique and Fiji Completed Physical activity and McArdle disease Ongoing Handwriting difficulties in children Completed Effects of dehydration and hyperthermia on brain and muscle blood flow Completed Use of Liquid Biopsies as Cancer Biomarkers Completed Low-cost Portable Molecular Diagnostic Platform Ongoing Development of innovative water cycles and value chains Ongoing Multi-sensory processing of faces and voices Completed International Sexuality Description Project Completed RHOMBUS: Rehabilitation via HOMe Based gaming exercise for the Upper-limb post Stroke Completed Bloodwise Completed Low-cost Diagnostic Platform for Detection of Poultry Infectious Pathogens Ongoing Plastic Oceans Completed Respiratory physiology, human performance and health Completed MESOVATS trial Completed The cost effectiveness of genetic markers for antibiotic resistance in tuberculosis Completed Revisiting oestrogenic effects in wild fish: assessing and comparing contemporary and historical impacts Completed An integrated computational-experimental method to redesign protein dynamics Ongoing Muscle response to exercise in cerebral palsy Completed Daiwa Foundation sponsored project with Tokyo University Completed Drug rescue of frataxin-dependent neural and cardiac pathophysiology in FA Completed Caspian climatic cycles for improved petroleum exploration Completed GAP WORK: Improving gender-related violence intervention and referral through youth practitioner training Completed DoReMi - LDR-OPTI-GEN - Low dose radiation-induced optical changes and genetic factors Completed Universities Supporting Victims of Sexual Violence Completed Microfluidics in Diagnosis Completed Surgical robotics for therapy and diagnosis Completed Orkney: Beside the Ocean of Time Completed A Decoy Artificial Snail Host to Control Schistosoma mansoni Completed Can roach, Rutilus rutilus, adapt to the harmful effects of oestrogen exposure from waste water treatment work effluents? Completed Investigation of Health Effects Associated with Exposure to Indirect Potable Reuse Drinking Water Completed Modelling infant leukaemia using gene editing technology Ongoing Impacts of palaeoenvironmental changes on Meso-Neolithic innovation and adaptation in the Caspian coast Completed PRIDE Drivers of Pontocaspian biodiversity Rise and Demise Completed Strength Training for Adolescents with cerebral palsy (STAR) Completed Protein Phosphatase 1 (PP1) in the Regulation of Mitotic Exit and Nuclear Organisation Completed A Data-Oriented Predictive Ecology Approach to Modelling Fish Communities during Regime Shifts Completed Posidonia as environmental archive: long-term ecology and conservation views Completed Muscle heat shock proteins with passive heating Completed Singing and Social Bonding: Creating connections between practitioners and researchers Completed Having Little, Having Less: Toward a Psychology of Low Socioeconomic Status Completed Stem cell mitotic response to damage in old and young Drosophila melanogaster Completed The wellbeing needs of older people living with sight loss Completed Living Well with Dementia (IDEAL) Completed What Works Wellbeing: Culture, Sport and Wellbeing Evidence Review: Social Diversity and Context Matters Completed Why aren't all old people lonely? A comparative analysis of European Union Completed Dare to Age Well Completed Tackling Ageing Continence through Theory, Tools and Technology (TACT3) Completed Development of a web-based decision aid to assist occupational therapists to make optimal fitness-to-drive decisions for disabled and older drivers Completed Pelvic floor exercise device for prevention and cure of Stress Urinary Incontinence in women Completed Scoping our future research priorities Completed New perspectives on loneliness: developing theory, methodology and evidence practice Completed Give and Take Care Completed Biologically inspired and self-powered dynamic systems Completed Hydration and human cardiovascular function Completed Disinfection of recirculating water systems Completed Chromosome dynamics and Nuclear Motors – Chromobility Completed Cytogenetic Assessment of British Nuclear Test Veterans and their Offspring Completed Understanding and Treatment of Hutchinson-Gilford Progeria Syndrome Completed Evaluation of oligonucleotides for therapy of Friedreich ataxia Completed Development of Smart Drilling Spindle Systems Completed Development of the functional surface u-texturing module with application to micromilling Completed