Biomedical Sciences research projects Our research-led academics are carrying out some of the most important scientific work to better understand, treat and develop cures for a wide range of human diseases. Below are some examples of the projects we have completed or are currently working on. Multifactorial impacts on early breast carcinogenesis Ongoing Engineering tissue scaffolds for organ-on-a-chip models Ongoing Organ-on-a-chip models for ovarian cancer Ongoing Vagina-on-a-Chip Ongoing Does CRISPR-Cas9 treatment cause DNA damage in cancer cells? Ongoing Pharmacological strategies for resolution of inflammation Ongoing Investigating thrombo-inflammation in disease Ongoing Manipulating our immune system to protect against ageing Ongoing Common genetic variants that increase the risk of cancer Completed Radiation exposure and heritable genetic effects Ongoing The role of early growth protein molecules in preventing autoimmune disease and cancer Ongoing Metabolic reprogramming of skin microenvironment for improved BCG vaccine efficacy Completed Promoting inflammation resolution in sickle cell disease Ongoing The role of the oncoprotein MYB in the head and neck cancer adenoid cystic carcinoma Ongoing Determinants and mechanisms involved in alcohol consumption and its health consequences Completed Understanding the effects of inflammation on brain and behaviour Ongoing Generation of novel approaches for testing metabolism disrupting chemicals Ongoing Understanding of the mechanisms underlying adverse effects of pharmaceuticals Completed Understanding the effects of cyclo-oxygenase inhibition in the zebrafish Ongoing Investigating the dysfunction of the cerebral microvasculature in sickle cell disease Ongoing Innate immunity in bovine tuberculosis Completed Host-pathogen interactions in tuberculosis Ongoing Human endogenous factors in the control of mycobacterial infection Ongoing How do cells divide? Chromatin re-organisation from mitosis to G1 Ongoing Investigating the role of CDCA2 molecule in neuroblastoma Ongoing Knowledge exchange on healthcare big data analytics Ongoing Elucidation of the metabolic signature of Friedreich's ataxia Completed Breathing muscle strength in healthy children Completed Artificial intelligent system for oncological volumetric medical PET classification Completed 3D Software Mapping For Osteoarthritis Pain Self-Management Completed Retinal image analysis Ongoing Statistical modelling of multi-omics data Completed Diabetes UK: Understanding physical activity Completed Side effects of gene therapy vectors Completed Innovative techniques for precise, atraumatic placement of cochlear implant (CI) Completed Modelling adenoid cystic carcinoma in a mouse Completed A new cell and gene therapy approach for Friedreich's ataxia Completed Scientific underpinnings of the clinical assessment of patellofemoral alignment Completed Biomechanical and sociological factors influencing pain and physical activity in children Completed Assessment of injury risk factors and mechanisms in elite netball Completed Vascular stiffness and distensibility in exercising humans Completed Optimising biomechanics of throwing performance Completed Circulating microvesicles responses to exercise and heat stress Completed Bike riding biomechanics and performance in children Completed The impact of hydration status on heat acclimation adaptations Completed Assessing the functional trajectories of people with chronic critical illness Completed Acute cardiovascular responses to slow and deep breathing Completed Preclinical studies of the inherited disease Friedreich ataxia Completed Respiratory responses to exercise in athletes with spinal cord injury Completed Effects of creatine supplementation on the airways of youth elite football players Completed Medicines and diagnostics in Mozambique and Fiji Completed Physical activity and McArdle disease Ongoing Effects of dehydration and hyperthermia on brain and muscle blood flow Completed Use of Liquid Biopsies as Cancer Biomarkers Completed Low-cost Portable Molecular Diagnostic Platform Completed Bloodwise Completed Low-cost Diagnostic Platform for Detection of Poultry Infectious Pathogens Completed Respiratory physiology, human performance and health Completed The cost effectiveness of genetic markers for antibiotic resistance in tuberculosis Completed Muscle response to exercise in cerebral palsy Completed Drug rescue of frataxin-dependent neural and cardiac pathophysiology in FA Completed Microfluidics in Diagnosis Completed Modelling infant leukaemia using gene editing technology Completed Strength Training for Adolescents with cerebral palsy (STAR) Completed Protein Phosphatase 1 (PP1) in the Regulation of Mitotic Exit and Nuclear Organisation Completed Muscle heat shock proteins with passive heating Completed Stem cell mitotic response to damage in old and young Drosophila melanogaster Completed Hydration and human cardiovascular function Completed Chromosome dynamics and Nuclear Motors – Chromobility Completed Cytogenetic Assessment of British Nuclear Test Veterans and their Offspring Completed Host: Pathogen interactions through the host genome Completed Drug treatments lead to Correction of Aberrant Genome Behaviour in Cancer and Immortalised Cells Completed Understanding and Treatment of Hutchinson-Gilford Progeria Syndrome Completed Evaluation of oligonucleotides for therapy of Friedreich ataxia Completed