Dr Christian Rudolph
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Summary

Dr. Rudolph is a world-renowned expert in bacterial DNA replication and repair, bacterial chromosome dynamics and bacterial chromosome structure. DNA replication is the fundamental process by which cells copy their genetic material to pass on to the next generation. His current research focuses on several key areas. First, he studies the final stage of DNA replication called termination and how this stage can threaten genomic stability. Second, he investigates how CRISPR-Cas systems (the molecular "scissors" made famous for gene editing) are connected to DNA replication and repair processes. Third, he examines how transcription can interfere with DNA replication, and how these interactions may have shaped bacterial chromosome organisation over evolutionary time. Finally, he explores how antibiotics and antibiotic-like substances, including artificial sweeteners, impact DNA replication and chromosome behaviour. Dr. Rudolph's ultimate goal is to understand in great detail how cells duplicate their genomes with high accuracy and what happens when these critical pathways fail. This research has important applications in both antibiotic development and understanding diseases triggered by genomic instability, such as cancer.