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PhD topics for research students

Find below a list of currently available self-funded PhD topics.

We encourage all students to contact the supervisor or the alternative contact person for more information and an informal chat to discuss the process of applying and preparing your research statement. For more information on how to apply click here.

Telomere length elongation following treatment with chemotherapeutic drugs.
Aim:  To investigate the mechanisms which leads to telomere length elongation after treatment with tricostatin A and azacytidine. Telomeres are specialised structures, which are present at the ends of...
Self Funded
Role of CDCA/PP1 in Triple Negative Breast Cancer (TNBC)
Estrogen, progesterone, and HER2 receptor-negative (triple-negative breast cancers TNBC) encompass the most clinically challenging subtype for which targeted therapeutics are lacking.  To identify cri...
Self Funded
The mutations in TP53 gene from the glioma patients that trigger the aberrant pre-mRNA splicing
TP53 gene encodes the “Tumour Protein” p53 which plays a central role in cell cycle regulation. This protein is widely considered as the “Guardian of the Genome” for maintaining genetic stability. A m...
Self Funded
Central Nervous system Gene therapy to treat obesity Bardet-Biedl Syndrome (BBS). Analysis of the BBS brain development
Bardet-Biedl syndrome (BBS) is a debilitating, often life-limiting heritable multisystem disorder caused by dysfunction of non-motile cilia (ciliopathy). There is currently no cure for BBS, a disease ...
Self Funded
Study of the ageing-related pre-mRNA splicing of the LMNA gene
Precursor messenger RNA (pre-mRNA) splicing is a cellular process in which non-coding sequences (introns) are removed and coding sequences (exons) are joined together to generate mRNA for protein prod...
Self Funded
Effects on the genome of new treatments for the premature ageing disease Hutchinson-Gilford Progeria Syndrome
HGPS is a premature ageing syndrome that affects children leading to their premature death in their teens through heart attacks and strokes. There have been a few drugs that have been given to the chi...
Self Funded
Nanoparticles in drug delivery
Nanoparticles (NPs) are materials with overall dimensions in the nano scale range (5nm-100nm). Due to their unique physicochemical properties, they have found a wide range of applications and are curr...
Self Funded
The impact of chromosomal rearrangements on the genome organisation of leukaemia cells.
Chromosomal rearrangements are a hallmark of leukaemia. It is well known that specific chromosomal rearrangements are associated with certain leukaemia subtypes and that can predict clinical outcome. ...
Self Funded
Budding yeast as a model for sudden cardiac death
Sudden unexpected cardiac death is responsible for about half of all heart disease deaths. It is an unexpected death caused by a change in heart rhythm. The underlying mechanisms are still not fully u...
Self Funded
Differential expression patterns and transport characteristics of aged cells
Ageing is associated with a number of diseases and manifests itself at the organ level (e.g. the morphological changes in the skin) as well as cellular level. Cellular function is dependent on correct...
Self Funded